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A Novel Solid-in-oil Nanosuspension for Transdermal Delivery of Diclofenac Sodium

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Abstract

Purpose

We formulated a solid-in-oil nanosuspension (SONS) as a novel transdermal delivery carrier for diclofenac sodium (DFNa). The basic transdermal characteristics of the SONS were evaluated using a Yucatan micropig (YMP) skin model.

Methods

DFNa-sucrose erucate (i.e. surfactant) complexes were prepared via the formation of a water-in-oil emulsion. The complexes were suspended in isopropyl myristate (IPM) to form a SONS. The basic transdermal characteristics of the SONS were examined using full-thickness YMP dorsal skin in a Franz-type diffusion cell. DFNa powder suspended in IPM without complex formation was used as a control. The effect of the weight ratio of surfactant to DFNa on DFNa penetration of the skin was evaluated.

Results

DFNa was successfully dispersed into IPM as a nanosized suspension via complex formation with sucrose erucate. The resultant SONS increased the permeability flux of DFNa across the YMP skin by up to 3.8-fold compared with the control. The size of the SONS depended on the weight ratio of the surfactant to DFNa. The optimal weight ratio for the highest DFNa permeation was 8.8, at which point the mean diameter of the SONS was 14.4 nm.

Conclusion

The SONS formulation can enhance the percutaneous absorption of DFNa.

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Acknowledgments

The present work was supported in part by the 21st Century COE Program “Functional Innovation of Molecular Informatics” from the Ministry of Education, Culture, Science, Sports and Technology of Japan (to M.G.). We would like to thank Mr. Hideki Horiuchi, a glassworker, for his skill in preparing specific Franz-type diffusion cells.

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Authors and Affiliations

  1. Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka, 819-0395, Japan

    Hongyu Piao, Noriho Kamiya & Masahiro Goto

  2. Center for Future Chemistry, Kyushu University, Fukuoka, 819-0395, Japan

    Noriho Kamiya & Masahiro Goto

  3. ASPION Corporation, Tokushima, Japan

    Akihiko Hirata & Takeru Fujii

Authors
  1. Hongyu Piao
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  2. Noriho Kamiya
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  3. Akihiko Hirata
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  4. Takeru Fujii
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  5. Masahiro Goto
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Correspondence to Masahiro Goto.

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Piao, H., Kamiya, N., Hirata, A. et al. A Novel Solid-in-oil Nanosuspension for Transdermal Delivery of Diclofenac Sodium. Pharm Res 25, 896–901 (2008). https://doi.org/10.1007/s11095-007-9445-7

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  • DOI: https://doi.org/10.1007/s11095-007-9445-7

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