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Inverse agonists of H1-receptors as promising antiallergy agents (a review)

  • Molecular-biological problems of drug design and mechanism of drug action
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Pharmaceutical Chemistry Journal Aims and scope

The review summarizes published data and presents original results that illustrate the variety of antiallergic properties of second generation antihistamine drugs. General notions of inverse agonists of H1-receptors and features of the receptor–ligand interaction that maintain H1-receptors in the non-active state are considered. The broadening of clinical indications for the administration of inverse agonists of H1-receptors aimed at preventing the exacerbation of allergic (atopic) disorders and inhibiting allergic inflammation processes is justified.

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Authors and Affiliations

  1. Institute of Immunology, Federal Medico-Biological Agency, Ministry of Public Health and Social Development of the Russian Federation, Moscow, 115478, Russia

    I. S. Gushchin

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  1. I. S. Gushchin
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 1, pp.3–8, January, 2010.

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Gushchin, I.S. Inverse agonists of H1-receptors as promising antiallergy agents (a review). Pharm Chem J 44, 1–6 (2010). https://doi.org/10.1007/s11094-010-0386-9

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  • DOI: https://doi.org/10.1007/s11094-010-0386-9

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