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Radiation sterilization of medicinal formulations of doxorubicin bound to poly(butylcyanoacrylate) nanoparticles

  • Drug Synthesis Methods and Manufacturing Technology
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Abstract

Polybutylcyanoacrylate nanoparticles represent a potential system for delivering medicinal agents. The present report describes development of a method for radiation sterilization of medicinal formulations of doxorubicin based on polybutylcyanoacrylate nanoparticles. The physicochemical properties of the medicinal formulation were studied after gamma irradiation and irradiation with accelerated electrons over the dose range 10–35 kGy. The chemical structure of doxorubicin and the polymer carrier was found to be intact after irradiation at a dose of 25 kGy. Irradiation at these doses also had no effect on the colloidal properties of polymer nanoparticles, which retained their stability to aggregation and sedimentation. The optimum sterilizing dose was 15 kGy.

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References

  1. S. M. Moghimi, A. C. Hunter, and J. C. Murray, FASEB J., 19(3), 311–330 (2005).

    Article  PubMed  CAS  Google Scholar 

  2. S.-S. Ferig and S. Chien, Chem. England. Sci., 58, 4087–4114 (2003).

    Article  Google Scholar 

  3. I. Brigger, C. Bubernet, and P. Couvreur, Adv. Drug Deliv. Rev., 54(5), 631–651 (2002).

    Article  PubMed  CAS  Google Scholar 

  4. A. E. Gulyaev, S. E. Gelperina, I. N. Skidan, et al., Pharm. Res., 16(10), 1564–1569 (1999).

    Article  PubMed  CAS  Google Scholar 

  5. S. C. J. Steiniger, J. Kreuter, A. S. Khalansky, et al., Int. J. Cancer, 109(5), 159–167 (2004).

    Article  Google Scholar 

  6. S. E. Gelperina, A. S. Khalansky, I. N. Skidan, et al., Toxicol. Lett., 126(2), 131–142 (2002).

    Article  PubMed  CAS  Google Scholar 

  7. J. Kattan, J.-P. Droz, P. Couvreur, et al., Invest. New Drugs, 10(3), 191–199 (1992).

    Article  PubMed  CAS  Google Scholar 

  8. E. Pereverzeva, I. Treschalin, D. Bodygin, et al., J. Control. Release (2006) (in press).

  9. C. Vauthier, E. Dubernet, E. Fattal, et al., Adv. Drug Deliv. Rev., 55(4), 519–548 (2003).

    Article  PubMed  CAS  Google Scholar 

  10. Handbook for Normative-Methodological Documents, Regulations for Radiation Sterilization of Medical Materials and Products [in Russian], Moscow (1980). Methods 1.5.2 and 1.5.3.

  11. Method for Estimating Initial Contamination of Products Sterilized by Radiation [in Russian], Ratified by the Ministry of Health, 00.02.82, Regulation No. 2535-82, Moscow (1982).

  12. Methodological Guide for the Use of an Indirect Method of Estimating Radioresistant Industrial Microflora at Establishments Producing Radiation Sterilized Products [in Russian], Ratified by the Ministry of Health, 10.10.90, Regulation No. 15-6 / 37, Moscow (1990).

  13. I. I. Samoilenko, E. P. Pavlov, and É. G. Tushov, Khim.-Farm. Zh., 2(5), 617–619 (1988).

    Google Scholar 

  14. Encyclopedia of Polymers [in Russian], Sovetskaya Éntsiklopediya (1977), pp. 871–872.

  15. P. Sommerfeld, U. Schroeder, and B. Sabel, Int. J. Pharm., 164(2), 113–118 (1998).

    Article  CAS  Google Scholar 

  16. C. Verdun, P. Couvreur, H. Vranckx, et al., J. Control. Rel., 3(2), 205–208 (1986).

    Article  CAS  Google Scholar 

  17. M. Fouarge, M. Dewulf, P. Couvreur, et al., J. Microencapsulation, 6(1), 29–34 (1989).

    Article  PubMed  CAS  Google Scholar 

  18. A. K. Pikaev, Current Radiation Chemistry. Solid Bodies and Polymers. Applied Aspects [in Russian], Nauka, Moscow (1987).

    Google Scholar 

  19. V. K. Milinchuk, É. R. Klinshpont, and V. I. Tupikov, Basic Radiation Resistance of Organic Materials [in Russian], Énergoatomizdat, Moscow (1994), pp. 142–147.

    Google Scholar 

  20. D. V. Paramonov, E. A. Antonova, N. G. Zharova, et al., Khim.-Farm. Zh., 30(10), 42–45 (1996).

    CAS  Google Scholar 

  21. USSR State Pharmacopeia [in Russian], 11th Edition, Part 2, Meditsina, Moscow (1989), p. 24.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 6, pp. 52–56, June, 2008.

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Maksimenko, O.O., Pavlov, E.P., Tushov, É.G. et al. Radiation sterilization of medicinal formulations of doxorubicin bound to poly(butylcyanoacrylate) nanoparticles. Pharm Chem J 42, 363–367 (2008). https://doi.org/10.1007/s11094-008-0128-4

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  • DOI: https://doi.org/10.1007/s11094-008-0128-4

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