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Gold nanoparticle shape effects on human serum albumin corona interface: a molecular dynamic study

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Abstract

In recent years, there has been considerable progress in the design and study of gold nanoparticles that geared toward biomedical applications. In most imaging and therapeutic applications, gold nanoparticles enter the bloodstream directly by intravenous administration forming molecular complexes with encountered proteins termed as the protein corona. Since albumin is the most abundant protein in human blood plasma, in this study, gold nanoparticle interactions and its shape effects on human serum albumin were studied by molecular dynamic simulation. These results revealed that in the interaction of albumin with any shapes of gold nanoparticle, human serum albumin unfolds and helix amount decreases. Cubic gold nanoparticles showed stronger unfolding effects on the albumin than the spherical gold nanoparticles.

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Acknowledgments

This paper is part of a PhD thesis in Nanomedicine by Mrs. Fatemeh Ramezani. Financial support was provided by Tehran University of Medical Sciences.

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Authors and Affiliations

  1. Department of Medical Physics and Biomedical Engineering, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fatemeh Ramezani & Hashem Rafii-Tabar

  2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Massoud Amanlou

Authors
  1. Fatemeh Ramezani
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  2. Massoud Amanlou
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  3. Hashem Rafii-Tabar
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Correspondence to Massoud Amanlou or Hashem Rafii-Tabar.

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Ramezani, F., Amanlou, M. & Rafii-Tabar, H. Gold nanoparticle shape effects on human serum albumin corona interface: a molecular dynamic study. J Nanopart Res 16, 2512 (2014). https://doi.org/10.1007/s11051-014-2512-1

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  • DOI: https://doi.org/10.1007/s11051-014-2512-1

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