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Exploring the development of a decision support system (DSS) to prioritize engineered nanoparticles for risk assessment

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Abstract

Engineered nanoparticles (ENPs) have gained huge commercial interest because of their unique and size-related physicochemical properties. The diversity and complexity of ENPs is increasing with the introduction of next generation nanoparticles. The current approaches are not able to assess the safety of all types and applications of ENPs. Therefore, we are developing a decision support system (DSS) that helps to identify those ENPs and applications that should get priority in the risk assessment. This DSS smartly uses existing knowledge in publicly available databases. With the aid of vocabularies, knowledge rules and logic reasoning new knowledge will be derived. In this paper, the procedure for a DSS is described. Since this system is open by design, others can re-use and extend the DSS content, and newly developed DSS tools can be easily accommodated, which will make the DSS more effective over the years. Data of newly emerging studies will be used for the validation of the DSS. The results will benefit regulating authorities and scientists focussing on the development of inherently safe ENPs.

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Notes

  1. http://cordis.europa.eu/fp7/cooperation/nanotechnology_en.html.

  2. http://www.nanonextnl.nl/.

  3. http://www.enpra.eu/.

  4. http://www.inlivetox.eu/.

  5. http://www.nanopolytox.eu/.

  6. http://www.nanolyse.eu/.

  7. https://secure.fera.defra.gov.uk/nanodetect/.

  8. http://www.qnano-ri.eu/.

  9. http://www.marina-fp7.eu/.

  10. http://www.nanovalid.eu/.

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Acknowledgments

This study was conducted in the framework of NanoNextNL (www.nanonextnl.nl) which is funded by the Dutch government.

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Authors and Affiliations

  1. RIKILT, Wageningen UR, P.O. Box 230, 6700 AE, Wageningen, The Netherlands

    Hans J. P. Marvin, Hans Bouwmeester & Henk van der Ham

  2. National Institute for Public Health and the Environment, RIVM, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands

    Martine Bakker & Francois Bourgeois

  3. TNO Innovation for Life, Earth, Environmental and Life Sciences, Utrechtseweg 48, 3704 HE, Zeist, The Netherlands

    E. Dinant Kroese

  4. Alterra, Wageningen UR, P.O. Box 47, 6700 AA, Wageningen, The Netherlands

    Rob Lokers & Lieke Verhelst

  5. Institute for Water and Wetland Research, Department of Environmental Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands

    Dik van de Meent

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  1. Hans J. P. Marvin
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  2. Hans Bouwmeester
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Correspondence to Hans J. P. Marvin.

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Marvin, H.J.P., Bouwmeester, H., Bakker, M. et al. Exploring the development of a decision support system (DSS) to prioritize engineered nanoparticles for risk assessment. J Nanopart Res 15, 1839 (2013). https://doi.org/10.1007/s11051-013-1839-3

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