Abstract
A simple method, chemical precipitation at low temperature from Ca(NO3)2·4H2O and (NH4)2HPO4 to tailor single phase, highly crystalline nanocrystal hydroxyapatite (HAp) powders was introduced in this paper. HAp powders with controlled morphologies (spherical and rod-like) and different grain sizes have been obtained by varying the reaction temperature, reaction mode, and heat treatment accordingly. X-ray diffraction (XRD) results combined with the Fourier transform-infrared spectroscopy (FT-IR) indicates that the single phase, nanocrystal HAp powder could be obtained in one-step without further heat treatment. At 40 °C with a quick mixing mode, ultra-fine complete spherical HAp particles with diameter range size of 20–50 nm could be obtained.
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References
Afshar A., Ghorbani M., Ehsani N., Saeri M.R., Sorrell C.C. (2003). Some important factors in the wet precipitation process of hydroxyapatite. Materials and design 24:197–202
Ahn E.S., Gleason N.J., Nakahira A., Ying J.Y. (2001). Nanostructure processing of hydroxyapatite-based Bioceramics. Nano Lett 1:149–153
Choi D.W., Marra K.G., Kumta P.N. (2004). Chemical synthesis of hydroxyapatite/poly(ε-caprolactone) composites. Materials Res Bull 39:417–432
Han Y.C., Li S.P., Wang X.Y., Chen X.M. (2004). Synthesis and sintering of nanocrystalline hydroxyapatite powders by citric acid sol-gel combustion method. Materials Res Bull 39:25–32
Ioku K., Yamauchi S., Fujimori H., Goto S., Yoshimura M. (2002). Hydrothermal preparation of fibrous apatite and apatite sheet. Solid State Ionics 151:147–150
Kim H.W., Koh Y.H., Li L.H., Leec S., Kim H.E. (2004a). Hydroxyapatite coating on titanium substrate with titania buffer layer processed by sol-gel method. Biomaterials 25:2533–2538
Kim T.S., Kumta P.N. (2004b). Sol-gel synthesis and characterization of nanostructured hydroxyapatite powder. Materials Sci Eng B 111:232–236
Kong Y.M., Bae C.J., Lee S.H., Kim H.W., Kim H.E. (2005). Improvement in biocompatibility of ZrO2–Al2O3 nano-composite by addition of HA. Biomaterials 26:509–517
Kumar R., Prakash K.H., Cheang P., Khor K.A. (2004) Temperature driven morphological changes of chemically precipitated hydroxyapatite nanoparticles. Langmuir 20(13):5196–5200
Kuriakose T.A., Kalkura S.N., Palanichamy M., Arivuoli D., Dierks K., Bocelli G., Betzel C. (2004). Synthesis of stoichiometric nano crystalline hydroxyapatite by ethanol-based sol–gel technique at low temperature. J Crystal Growth 263:517–523
Liu D.M., Yang Q.Z., Troczynski T. (2002) Water-based sol-gel synthesis of hydroxyapatite: process development. Biomaterials 23:691–698
Liu H.S., Chin T.S., Lai L.S., Chiu S.Y., Chung K.H., Changb C.S., Lui M.T. (1997). Hydroxyapatite synthesized by a simplified hydrothermal method. Ceramics Int 23:19–25
Liu Y.K., Hou D.D., Wang G.H. (2004). A simple wet chemical synthesis and characterization of hydroxyapatite nanorods. Materials Chem Phy 86:69–73
Mochales C., Briak-Benabdeslam H.E., Ginebra M.P., Terol A., Planell J.A., Boudeville P. (2004). Dry mechanochemical synthesis of hydroxyapatites from DCPD and CaO: influence of instrumental parameters on the reaction kinetics. Biomaterials 25:1151–1158
Riman R.E., Suchaned W.L., Byrappa K., Chen C.W., Shuk P., Oakes C.S. (2002). Solution synthesis of hydroxyapatite designer particulates. Solid State Ionics 151:393–402
Wu W.J., Nancollas G.H. (1997). Kinetics of nucleation and crystal growth of hydroxyapatite and fluorapatite on titanium oxide surfaces. Colloids and Surfaces B Biointerfaces 10:87–94
Yeong K.C.B., Wang J., Ng S.C. (2001). Mechanochemical synthesis of nanocrystalline hydroxyapatite from CaO and CaHPO4. Biomaterials 22:2705–2712
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The present work is supported by Chinese Natural Science Foundation and “Xibuzhiguang 2004” of Chinese Academy of Sciences.
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Zhang, Y., Lu, J. A simple method to tailor spherical nanocrystal hydroxyapatite at low temperature. J Nanopart Res 9, 589–594 (2007). https://doi.org/10.1007/s11051-006-9177-3
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DOI: https://doi.org/10.1007/s11051-006-9177-3