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The application of super paramagnetic iron oxide-labeled mesenchymal stem cells in cell-based therapy

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Abstract

Mesenchymal stem cell (MSC)-based therapy has great potential for tissue regeneration. However, being able to monitor the in vivo behavior of implanted MSCs and understand the fate of these cells is necessary for further development of successful therapies and requires an effective, non-invasive and non-toxic technique for cell tracking. Super paramagnetic iron oxide (SPIO) is an idea label and tracer of MSCs. MRI can be used to follow SPIO-labeled MSCs and has been proposed as a gold standard for monitoring the in vivo biodistribution and migration of implanted SPIO-labeled MSCs. This review discusses the biological effects of SPIO labeling on MSCs and the therapeutic applications of local or systemic delivery of these labeled cells.

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Acknowledgments

The project was supported by the Science Technology Program of Zhejiang Province (2008C13025); the Natural Science Foundation of China (81071259, 81271356) and the Natural Science Grants of Zhejiang Province (Y2090283, LZ12H16002).

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All authors have no conflicts of interest.

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  1. Department of Orthopaedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China

    Yiying Qi, Gang Feng, Zhongming Huang & Weiqi Yan

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  1. Yiying Qi
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Correspondence to Weiqi Yan.

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Qi, Y., Feng, G., Huang, Z. et al. The application of super paramagnetic iron oxide-labeled mesenchymal stem cells in cell-based therapy. Mol Biol Rep 40, 2733–2740 (2013). https://doi.org/10.1007/s11033-012-2364-7

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