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A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy

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Abstract

Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 19 case–control studies including 1,378 cases and 10,383 controls provided data on the association between HLA-DR polymorphism and genetic susceptibility to IDC. Overall, statistically elevated frequencies of HLA-DR4 (OR 1.58; 95% CI 1.21–2.07; P = 0.0009) and HLA-DR5 (OR 1.35; 95% CI 1.05–1.73; P = 0.02) alleles were found in patients with IDC compared with controls. Individuals with HLA-DR3 antigen have a protective effect against IDC (OR 0.72; 95% CI 0.58–0.90; P = 0.004). In summary, this meta-analysis indicated that certain HLA-DR alleles may be genetic markers for susceptibility and resistance to IDC.

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Acknowledgments

We gratefully acknowledge Dr. Ying Shan for her editorial suggestions for the article. This study was supported in part by the 11th Five-year National Science Project on Chronic Heart Failure in China (2006BAI01A04).

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Authors and Affiliations

  1. Department of Cardiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China

    Bo Jin, Xin-Ping Luo, Huan-Chun Ni, Wei Shen, Hai-Ming Shi & Yong Li

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  1. Bo Jin
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  2. Xin-Ping Luo
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  3. Huan-Chun Ni
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  4. Wei Shen
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  5. Hai-Ming Shi
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  6. Yong Li
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Corresponding author

Correspondence to Yong Li.

Additional information

B. Jin and X.P. Luo contributed equally to this work and should be considered as co-first authors.

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Jin, B., Luo, XP., Ni, HC. et al. A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy. Mol Biol Rep 39, 221–226 (2012). https://doi.org/10.1007/s11033-011-0729-y

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  • DOI: https://doi.org/10.1007/s11033-011-0729-y

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