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The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes

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Abstract

Uncoupling protein 1 (UCP1), a 32-kDa protein located in the inner mitochondrial membrane, is abundant in brown adipose tissue, as a proton transporter in mitochondria inner membrane which uncouples oxidative metabolism from ATP synthesis and dissipates energy through the heat. UCP1 has been reported to play important roles for energy homeostasis in rodents and neonate of larger mammals including human. Recently, numerous candidate genes were searched to determine the genetic factors implicated in the pathogenesis of obesity, related metabolic disorders and diabetes. UCP-1, which plays a major role in thermogenesis, was suggested to be one of the candidates. This review summarizes data supporting the existence of brown adipocytes and the role of UCP1 in energy dissipation in adult humans, and the genetic variety association with the fat metabolism, obesity and diabetes.

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Acknowledgments

The research reported herein was funded by grants from Projects: Yunnan Natural Found Project: A role for Uncoupling proteins in the control of energy utilisation in pigs (2003C0048M); The relationship of the polymorphisms of UCP2 gene and economic trait (2006C0033Q). The prophase Project 973 of the People’s Republic of China: Yunnan Wujing Pigs Meat Quality Research (2007CB116201-3). The foundation for talented man training in Yunnan Province of the People’s Republic of China (2008PY043).

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Authors and Affiliations

  1. Yunnan Provincial Laboratory of Animal Nutrition and Feed Science, Yunnan Agricultural University, 650201, Kunming, Yunnan Province, People’s Republic of China

    Jun-jing Jia, Zhen-hui Cao, Lin-li Tao, Xi Zhang, Si-zhen Gao, Chang-rong Ge & Qiu-Ye Lin

  2. College of ZhongKai Agricultural Technology and Science, 510225, Guangzhou, Guangdong Province, People’s Republic of China

    Yun-bo Tian

  3. Department of Agriculture, School of Life Sciences, La Trobe University, Bundoora, 3086, VIC, Australia

    M. Jois

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  1. Jun-jing Jia
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  2. Yun-bo Tian
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Correspondence to Chang-rong Ge or Qiu-Ye Lin.

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Jia, Jj., Tian, Yb., Cao, Zh. et al. The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes. Mol Biol Rep 37, 1513–1522 (2010). https://doi.org/10.1007/s11033-009-9550-2

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