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Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation

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Abstract

In this study, we prospectively investigated the immune reconstitution in patients with hematological malignancies after human leukocyte antigen (HLA)-mismatched/unmanipulated haploidentical transplantation (50 cases) and HLA-matched transplant (25 cases). Transplant-related mortality, relapse, leukemia-free survival, and overall survival were similar between the two transplant strategies, although the cumulative incidence of CMV antigenemia was significantly higher in haploidentical recipients than in HLA-matched recipients (49.9 ± 7.2% versus 13 ± 7%, P = 0.007). Compared with HLA-matched recipients, T-cell subset and dendritic cell subgroup cell counts in the first 90 days after grafting were lower in haploidentical recipients. The difference was most striking for CD4+ and CD4+ naïve T cells. Reconstitution of B cells and monocytes was comparable between groups. T cells appeared equally functional in both groups among patients without graft-versus-host disease. Our results suggest that the clinical outcomes were not compromised by the early delayed immune reconstitution following haploidentical transplantation.

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Acknowledgements

This work was supported by the National Outstanding Young Scientist's Foundation of China (grant no. 30725038), National Natural Science Foundation of China (grant no. 30971292 and 30800485), and Beijing Novel program (grant no. 2008B05). We would like to thank San Francisco Edit (www.sfedit.net) for their assistance in editing this manuscript.

Disclosure of Conflicts of Interest

The authors declared no competing financial interests.

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Authors and Affiliations

  1. Peking University People’s Hospital & Institute of Hematology, No 11 Xizhimen South Street, Beijing, 100044, China

    Ying-Jun Chang, Xiang-Yu Zhao, Ming-Rui Huo, Lan-Ping Xu, Dai-Hong Liu, Kai-Yan Liu & Xiao-Jun Huang

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  1. Ying-Jun Chang
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  2. Xiang-Yu Zhao
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Correspondence to Xiao-Jun Huang.

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Chang, YJ., Zhao, XY., Huo, MR. et al. Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation. J Clin Immunol 32, 268–280 (2012). https://doi.org/10.1007/s10875-011-9630-7

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