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Effect of gelatin on the drug release behaviors for the organic hybrid gels based on N-isopropylacrylamide and gelatin

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Abstract

A series of organic hybrid gels were prepared based on poly(N-isopropylacrylamide), poly(NIPAAm), and gelatin. The hybrid gels were crosslinked through a two-step process with genipin or glutaraldehyde. The swelling behavior and physical properties of the gels were investigated in the previous report. In this study, we loaded sulfanilamide, caffeine, vitamin B12, phenol red, and neutral red in the hybrid gels. The effects of gelatin on the drug release profile were demonstrated. The ionicity of hybrid gels strongly influenced the release of phenol red (anionic) and neutral red (cationic). However, the releases of sulfanilamide, caffeine and vitamin B12 were not influenced by the ionicity of hybrid gel. The drug released from the gels crosslinked with genipin was significantly smaller than that released from the gels crosslinked with glutaraldehyde.

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Acknowledgments

The authors gratefully acknowledge financial support of this research by the Tatung University, Taipei, Taiwan, under grant number 91-1413-01.

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  1. Department of Chemical Engineering, Tatung University, Taipei, 10451, Taiwan, Republic of China

    Wen-Fu Lee & Sung-Chuan Lee

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  1. Wen-Fu Lee
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  2. Sung-Chuan Lee
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Correspondence to Wen-Fu Lee.

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Lee, WF., Lee, SC. Effect of gelatin on the drug release behaviors for the organic hybrid gels based on N-isopropylacrylamide and gelatin. J Mater Sci: Mater Med 18, 1089–1096 (2007). https://doi.org/10.1007/s10856-007-0142-1

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