Skip to main content

Advertisement

SpringerLink
Log in

Alkali ion substituted calcium phosphate cement formation from mechanically activated reactants

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

Potassium and sodium containing nanoapatite cements were produced from Ca2KNa(PO4)2 by prolonged high energy ball milling of the compound for up to 24 h. This mechanical treatment resulted in the decrease of the crystal size and a partial amorphisation of the cement reactant as shown by X-ray diffraction analysis and the appearance of strong exothermic peaks in differential scanning calorimetry measurements. The pH of water saturated with Ca2KNa(PO4)2 was 12.5 when the material was mechanically activated but was only 9.5 for the untreated compound suggesting an increase in solubility following milling. The cements set following mixing with a 2.5% Na2HPO4 solution in clinically acceptable times between 5–12 min and showed compressive strengths of up to 11 MPa after 24 h setting. The strong alkaline pH value of the cements may provide antimicrobial potential for an application in dentistry as pulp capping agents or cavity liners or for the treatment of infected bone sites.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. C. CHOW, J. Ceramic. Soc. Japan 99 (1991) 954.

    CAS  Google Scholar 

  2. Y. LI, X. ZHANG and K. DE GROOT, Biomaterials 18 (1997) 737.

    Article  CAS  PubMed  Google Scholar 

  3. K. S. TENHUISEN and P. W. BROWN, ibid. 19 (1998) 2209.

    Article  CAS  PubMed  Google Scholar 

  4. Y. MIYAMOTO, T. TOH, K. ISHIKAWA, T. YUASA, M. NAGAYAMA and K. SUZUKI, J. Biomed. Mater. Res. 54 (2001) 311.

    Article  CAS  PubMed  Google Scholar 

  5. F. C. M. DRIESSENS, M. G. BOLTONG, E. A. P. De MAEYER, R. WENZ, B. NIES and J. A. PLANELL, Biomaterials 23 (2002) 4011.

    Article  CAS  PubMed  Google Scholar 

  6. O. BERMUDEZ, M. G. BOLTONG, F. C. M. DRIESSENS, M. P. GINEBRA, E. FERNANDEZ and J. A. PLANELL, ibid. 15 (1994) 1019.

    Article  CAS  PubMed  Google Scholar 

  7. N. SANIN, S. TAKAGI, L. C. CHOW and S. MATSUYA, IADR (1991), Abstract No. 2411.

  8. M. OTSUKA, Y. MATSUDA, Y. SUWA, J. L. FOX and W. I. HIGUCHI, J. Biomed. Mater. Res. 29 (1995) 25.

    CAS  PubMed  Google Scholar 

  9. U. GBURECK, O. GROLMS, J. E. BARRALET, L. M. GROVER and R. THULL, Biomaterials 24 (2003) 4123.

    Article  CAS  PubMed  Google Scholar 

  10. U. GBURECK, J. E. BARRALET, M. HOFMANN and R. THULL, J. Am. Ceram. Soc. 87 (2004) 311.

    CAS  Google Scholar 

  11. L. C. CHOW, S. HIRAYAMA, S. TAKAGI and E. PARRY, J. Biomed. Mater. Res. (Appl. Biomater.) 53 (2000) 511.

    Article  CAS  Google Scholar 

  12. ASTM-Standard C266-99: Standard Test Method for Time of Setting of Hydraulic Cement Paste by Gilmore Needles, ASTM International 2002.

  13. D. B. KAMERER, C. D. FRIEDMAN, P. D. COSTANTINO, C. H. SNYDERMAN and B. F. HIRSCH, Am. J. Otol. 15 (1994) 47.

    CAS  PubMed  Google Scholar 

  14. J. F. KVETON, C. D. FRIEDMAN and P. D. CONSTANTINO, Am. J. Otol. 16 (1995) 465.

    CAS  PubMed  Google Scholar 

  15. U. GBURECK, J. E. BARRALET, L. RADU, H. G. KLINGER and R. THULL, J. Am. Ceram. Soc. 87 (2004).

  16. J. E. BARRALET, M. HOFMANN, L. M. GROVER and U. GBURECK, Adv. Mater. 15 (2003) 2091.

    Article  CAS  Google Scholar 

  17. E. RYSHKEWITCH, J. Am. Ceram. Soc. 36 (1953) 65.

    Google Scholar 

  18. U. GBURECK, J. E. BARRALET, K. SPATZ, L. M. GROVER and R. THULL, Biomaterials 25 (2004) 2187.

    Article  CAS  PubMed  Google Scholar 

  19. H. J. STAEHLE, T. POICH and W. HOPPE, Endod. Dent. Traumatol. 5(3) (1989) 147.

    CAS  PubMed  Google Scholar 

  20. H. EL BRIAK, D. DURAND, J. NURIT, S. MUNIER, B. PAUVERT and P. BOUDEVILLE, J. Biomed. Mater. Res. 63 (2002) 447.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, D-97070, Wúrzburg, Germany

    U. Gbureck & R. Thull

  2. Faculty of Dentistry, McGill University, Strathcona Anatomy & Dentistry Building, 3640 University St., Montreal, Quebec, H3A 2B2, Canada

    J. E. Barralet

Authors
  1. U. Gbureck
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Thull
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. E. Barralet
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gbureck, U., Thull, R. & Barralet, J.E. Alkali ion substituted calcium phosphate cement formation from mechanically activated reactants. J Mater Sci: Mater Med 16, 423–427 (2005). https://doi.org/10.1007/s10856-005-6982-7

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-005-6982-7

Keywords

Search

Navigation