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Safety and efficacy of catheter ablation of atrial fibrillation in patients with diabetes mellitus—single center experience

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Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Background and objective

Little is known about the outcome of catheter ablation of atrial fibrillation (AF) in patients with diabetes mellitus (DM). We investigated the safety and efficacy of catheter ablation of AF in patients with DM.

Materials and methods

Thirty one patients with DM from a group of 263 consecutive patients undergoing a first-time catheter ablation of AF procedure were enrolled in a prospective study. The ablation protocol (guided by CARTO system) consisted in two continuous circular lesions around ipsilateral pulmonary veins.

Results

The following clinical characteristics differed between DM and no-DM patients: age (62.0 ± 10.8 vs. 56.1 ± 10.6 years, P = 0.004), longer AF history (9.6 ± 9.3 vs. 6.7 ± 6.3 years, P = 0.024), significantly larger left atrium size (41.1 ± 7.8 vs. 38.3 ± 5.8 mm, P = 0.021), hypertension (58.1 vs. 35.8%, P = 0.018) and structural heart disease (67.7 vs. 43.5%, P = 0.011). Despite a similar AF recurrence rate in DM and no-DM patients (32.3 vs. 22.4%, P = 0.240), the ablation procedure was complicated in 28 patients (11 hematomas, three cardiac tamponades and three strokes) and the incidence of complications was significantly higher in DM than in no-DM patients (29.0 vs. 8.2%, respectively, P = 0.002). Multivariate analysis showed that DM was an independent risk factor for complications occurrence (odd ratio 5.936, 95% confidence interval 2.059 to 17.112, P = 0.001).

Conclusions

First catheter ablation of AF procedure in DM patients was equally efficacious than in no-DM patients. However, DM patients had a higher incidence of complications, mostly thrombotic or hemorrhagic.

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Authors and Affiliations

  1. Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing, China

    Ri Bo Tang, Jian Zeng Dong, Xing Peng Liu, Dong Ping Fang, De Yong Long, Xiao Hui Liu, Rong Hui Yu, Fu Li Hu, Chun Shan Lu, Peng Hao & Chang Sheng Ma

  2. Institute for Cardiovascular Research, Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA

    Jérôme Kalifa

  3. Ward 2nd, Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Chaoyang District, Beijing, People’s Republic of China, 100029

    Chang Sheng Ma

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  1. Ri Bo Tang
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Correspondence to Chang Sheng Ma.

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Tang, R.B., Dong, J.Z., Liu, X.P. et al. Safety and efficacy of catheter ablation of atrial fibrillation in patients with diabetes mellitus—single center experience. J Interv Card Electrophysiol 17, 41–46 (2006). https://doi.org/10.1007/s10840-006-9049-x

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  • DOI: https://doi.org/10.1007/s10840-006-9049-x

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