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Blackberry-induced hand-foot skin reaction to sunitinib

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An Erratum to this article was published on 18 February 2009

Summary

Sunitinib is an orally administered small molecule that was approved by the US Food and Drug Administration in January 2006 as monotherapy for the treatment of patients with advanced renal cell carcinoma (RCC) and patients with gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate. Data pooled from multiple sunitinib dose-escalation trials showed that sunitinib is associated with various adverse events, with HFSR occurring in up to 20% of patients. We describe a 48-year-old woman with a history of metastatic colorectal cancer treated with single-agent sunitinib who developed pain and tenderness in areas of friction secondary to Blackberry use, and was diagnosed with trauma-induced hand-foot skin reaction (HFSR) secondary to sunitinib therapy.

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Authors and Affiliations

  1. Department of Dermatology, Northwestern University’s Feinberg School of Medicine, 676 N. St. Clair St., Suite 1600, Chicago, IL, 60611, USA

    Susan L. Boone & Mario E. Lacouture

  2. Department of Medicine Arizona Cancer Center, Tucson, AZ, 85724-5024, USA

    Gayle Jameson & Daniel Von Hoff

  3. SERIES Clinic, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, 60611, USA

    Mario E. Lacouture

Authors
  1. Susan L. Boone
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  2. Gayle Jameson
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  3. Daniel Von Hoff
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  4. Mario E. Lacouture
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Corresponding author

Correspondence to Mario E. Lacouture.

Additional information

M.E.L. is supported by a Zell Scholarship from the Robert H Lurie Cancer Center.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10637-009-9226-8

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Boone, S.L., Jameson, G., Von Hoff, D. et al. Blackberry-induced hand-foot skin reaction to sunitinib. Invest New Drugs 27, 389–390 (2009). https://doi.org/10.1007/s10637-008-9196-2

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  • DOI: https://doi.org/10.1007/s10637-008-9196-2

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