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Efficacy of Rabeprazole in the Treatment of Symptomatic Gastroesophageal Reflux Disease

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Abstract

The purpose of this study was to assess the rapidity of symptom relief and 4-week efficacy of rabeprazole 20 mg in patients with moderately severe nonerosive gastroesophageal reflux disease. Data were analyzed from 2 similarly designed, double-blind, placebo-controlled, multicenter, U.S. trials. After a 2-week placebo run-in period, patients (N = 261) were randomized to 4 weeks of rabeprazole 20 mg once daily or placebo. Patients kept symptom diaries and scored symptom severity. Median time to first 24-hour heartburn-free interval was 3.5 days for the rabeprazole group compared with 19.5 days for the placebo group (P ≤ .0002). Complete heartburn relief at week 4 was 32% with rabeprazole and 3.8% with placebo (P ≤ .001). Rabeprazole also significantly improved other GERD-associated symptoms (e.g., regurgitation, belching, early satiety) by week 4 compared with placebo (P ≤ .05). Rabeprazole provides fast and potent relief from heartburn and other symptoms of nonerosive gastroesophageal reflux disease.

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Authors and Affiliations

  1. Northwestern University Feinberg School of Medicine, Chicago, Illinois

    Peter J. Kahrilas MD

  2. Oklahoma Foundation for Digestive Research, Oklahoma City, Oklahoma

    Philip Miner MD

  3. Rockford Gastroenterology Associates, Rockford, Illinois

    John Johanson MD

  4. Janssen Pharmaceutica Inc., Titusville, New Jersey

    Lian Mao MS & Leonard Jokubaitis MD

  5. Section of Gastroenterology, Suite 1400, 676 N St Clair Street, Chicago, IL, 60611-2951

    Peter J. Kahrilas MD & Sheldon Sloan MD

Authors
  1. Peter J. Kahrilas MD
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  2. Philip Miner MD
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  3. John Johanson MD
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  4. Lian Mao MS
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  5. Leonard Jokubaitis MD
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  6. Sheldon Sloan MD
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Corresponding author

Correspondence to Peter J. Kahrilas MD.

Additional information

Supported by Eisai Inc., Teaneck, New Jersey, and Janssen Pharmaceutica Inc., Titusville, New Jersey.

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Kahrilas, P.J., Miner, P., Johanson, J. et al. Efficacy of Rabeprazole in the Treatment of Symptomatic Gastroesophageal Reflux Disease. Dig Dis Sci 50, 2009–2018 (2005). https://doi.org/10.1007/s10620-005-3000-3

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  • DOI: https://doi.org/10.1007/s10620-005-3000-3

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