Abstract
Idiopathic chronic urticaria (ICU) is a chronic relapsing cutaneous disease. Some case reports or studies on small series of celiac disease (CD) patients have suggested a possible association between CD and ICU. The aim of this study was to assess the prevalence of CD in a population of adults ICU patients with respect to healthy controls. We consecutively enrolled 80 patients affected by ICU and 264 blood donors as the control population without a history of ICU. Serum anti-transglutaminase IgG and anti-endomysium IgA antibodies were evaluated in all subjects. In the case of positivity to serology, diagnosis was confirmed by duodenal biopsy. One of 80 (1.25%) ICU patients were positive to both anti-transglutaminase and anti-endomysium antibodies. Duodenal biopsy showed partial villous atrophy. One control of 264 (0.38%) had CD. No statistical difference was found in the prevalence of CD between the two groups. ICU patients do not seem to bear a greater risk for CD compared to the general population.
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References
Kaplan AP: Clinical practice. Chronic urticaria and angioedema. N Engl J Med 346:175–179, 2002
Greaves MW: Chronic idiopathic urticaria. Curr Opin Allergy Clin Immunol 3:363-368, 2003
Green PH, Jabri B: Coeliac disease. Lancet 362:383–391, 2003
Maki M, Mustalahti K, Kokkonen J, Kulmala P, Haapalahti M, Karttunen T, Ilonen J, Laurila K, Dahlbom I, Hansson T, Hopfl P, Knip M: Prevalence of Celiac disease among children in Finland. N Engl J Med 348(19):2517–2524, 2003
Farrell RJ, Kelly CP: Celiac sprue. N Engl J Med 346:180–188, 2002
Hautekeete ML, DeClerck LS, Stevens WJ: Chronic urticaria associated with coeliac disease. Lancet 1:157, 1987
Gallo C, Vighi G, Schroeder J, Strozzi M, Scibilia J, Colafrancesco M, Rota E, Ortolani C, Brusamolino R, Barberis M: Chronic urticaria atopic dermatitis and celiac disease. Am J Gastroenterol 87:1684, 1992
Levine A, Dalal I, Bujanover Y: Celiac disease associated with familial chronic urticaria and thyroid autoimmunity in a child. Pediatrics 104:e25, 1999
Farkas H, Visy B, Fekete B, Karadi I, Kovacs JB, Kovacs IB, Kalmar L, Tordai A, Varga L: Association of celiac disease and hereditary angioneurotic edema. Am J Gastroenterol 97:2682–2683, 2002
Mery A: Celiac disease presenting as urticaria. Allergy Asthma Proc 25(2):97–99, 2004
Candelli M, Nista EC, Gabrielli M, Santarelli L, Pignataro G, Cammarota G, Gasbarrini G, Gasbarrini A: Celiac disease and chronic urticaria resolution: a case report. Dig Dis Sci 49:1489–1490, 2004
Scala E, Giani M, Pirrotta L, Guerra EC, Guerra EC, De Pita O, Puddu P: Urticaria and adult celiac disease. Allergy 54:1008–1009, 1999
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Gabrielli, M., Candelli, M., Cremonini, F. et al. Idiopathic Chronic Urticaria and Celiac Disease. Dig Dis Sci 50, 1702–1704 (2005). https://doi.org/10.1007/s10620-005-2919-8
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DOI: https://doi.org/10.1007/s10620-005-2919-8