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Composition, structural characteristics, and antitumor properties of polysaccharides from the brown algae Dictyopteris polypodioides and Sargassum sp.

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Chemistry of Natural Compounds Aims and scope

The polysaccharide compositions of the brown algae Dictyopteris polypodioides and Sargassum sp. from the Mediterranean Sea were determined. The principal polysaccharide of the studied algae (about 12% of the dry alga weight) was alginic acid. The content of water-soluble polysaccharides was low. The amount of fucoidan was less than 1% of the dry alga weight; of neutral polysaccharides, less than 0.25%. The monosaccharide compositions of fucoidans and neutral polysaccharides were investigated. Experiments on soft agar-agar models showed that fucoidans from D. polypodioides and Sargassum sp. exhibited antitumor activity against RPMI-7951 human melanoma cells.

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Acknowledgment

The work was supported by RFBR Grant No. 09-04-00761-a and the Molecular Cellular Biology Program. We thank Prof. V. V. Isakov and Cand. Chem. Sci. S. D. Anastyuk (PIBOC, FEB, RAS) for recording spectra and assisting with their interpretation.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry, Far-East Division, Russian Academy of Sciences, 690022, Vladivostok, Prosp. 100-Letiya Vladivostoka, 159, Russia

    R. V. Sokolova, S. P. Ermakova & T. N. Zvyagintseva

  2. Laboratory of Biotechnology of Natural Substances and Health Products, Faculty of Pharmacy, Lebanese University, Beirut, Lebanon

    S. M. Awada & H. M. Kanaan

Authors
  1. R. V. Sokolova
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  2. S. P. Ermakova
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  3. S. M. Awada
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  4. T. N. Zvyagintseva
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  5. H. M. Kanaan
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Correspondence to R. V. Sokolova.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 297–301, May–June, 2011.

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Sokolova, R.V., Ermakova, S.P., Awada, S.M. et al. Composition, structural characteristics, and antitumor properties of polysaccharides from the brown algae Dictyopteris polypodioides and Sargassum sp.. Chem Nat Compd 47, 329 (2011). https://doi.org/10.1007/s10600-011-9925-1

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  • DOI: https://doi.org/10.1007/s10600-011-9925-1

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