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Rho GTPases: functions and association with cancer

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Abstract

Rho GTPases are small proteins that act as binary molecular switches in a wide range of signalling pathways upon stimulation of cell surface receptors. Three different classes of regulatory proteins control their activity. In the activated state small GTPases are able to bind a variety of effector proteins and initiate downstream signalling. Rho GTPases regulate important cellular processes ranging from cytoskeletal remodelling and gene expression to cell proliferation and membrane trafficking. Therefore it is not surprising that deregulated Rho signalling can contribute to disturbed cellular phenotypes in a wide range of diseases. The main focus of this review will be the diversity of functions of Rho GTPases and the effects of aberrant Rho GTPase signalling in various aspects of cancer.

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Abbreviations

AJ:

Adherens junction

Arp:

Actin-related protein

DH:

Dbl homology

DOCK:

Dedicator of cytokinesis

EMT:

Epithelial-mesenchymal transition

ERK:

Extracellular signal-regulated kinase

GAP:

GTPase-activating protein

GDI:

Guanine nucleotide dissociation inhibitor

GEF:

Guanine nucleotide exchange factor

MMP:

Matrix metalloproteinase

NFκB:

Nuclear factor κB

N-WASP:

Neural Wiskott-Aldrich-syndrome protein

PAK:

p21-activated kinase

PH:

Pleckstrin homology

PKC:

Protein kinase C

ROCK:

Rho-associated coiled-coil containing protein kinase

ROS:

Reactive oxygen species

SRF:

Serum response factor

Tiam1:

T-lymphoma invasion and metastasis 1

TJ:

Tight junction

WAVE:

WASP-like verprolin-homologous protein

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Ellenbroek, S.I.J., Collard, J.G. Rho GTPases: functions and association with cancer. Clin Exp Metastasis 24, 657–672 (2007). https://doi.org/10.1007/s10585-007-9119-1

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