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PTPL1: a large phosphatase with a split personality

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Abstract

Protein tyrosine phosphatase, PTPL1, (also known as PTPN13, FAP-1, PTP-BAS, PTP1E) is a non-receptor type PTP and, at 270 kDa, is the largest phosphatase within this group. In addition to the well-conserved PTP domain, PTPL1 contains at least 7 putative macromolecular interaction domains. This structural complexity indicates that PTPL1 may modulate diverse cellular functions, perhaps exerting both positive and negative effects. In accordance with this idea, while certain studies suggest that PTPL1 can act as a tumor-promoting gene other experimental studies have suggested that PTPL1 may function as a tumor suppressor. The role of PTPL1 in the cancer cell is therefore likely to be both complex and context dependent with possible roles including the modulation of growth, stress-response, and cytoskeletal remodeling pathways. Understanding the nature of molecular complexes containing PTPL1, its interaction partners, substrates, regulation and subcellular localization are key to unraveling the complex personality of this protein phosphatase.

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Abbreviations

ESFT:

Ewing’s Sarcoma Family of Tumors

FERM:

band 4.1/ezrin/radixin/moesin

IκBα:

Inhibitor of nuclear factor kappa-B alpha

KIND:

Kinase non-catalytic C-lobe domain

PARG1:

PTPL1-associated RhoGAP1

PDZ:

PSD-95/Discs-large/ZO-1

PIP:

Phosphatidylinositol biphosphates

PIP3:

Phosphatidylinositol triphosphates

PKA:

Protein kinase-A

PTP:

Protein Tyrosine Phosphatase

TAPP:

Tandem-PH-domain-containing proteins

TNFR:

Tumor necrosis factor-receptor

TRIP6:

Thyroid Hormone Receptor-interacting Protein 6

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Acknowledgements

The authors would like to thank Toretsky Lab members for helpful discussions and Ms. Audrey Kubetin for editorial assistance.

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  1. Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA

    Ogan D. Abaan & Jeffrey A. Toretsky

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Correspondence to Jeffrey A. Toretsky.

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Abaan, O.D., Toretsky, J.A. PTPL1: a large phosphatase with a split personality. Cancer Metastasis Rev 27, 205–214 (2008). https://doi.org/10.1007/s10555-008-9114-2

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