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Gastrectomy and risk of pancreatic cancer: systematic review and meta-analysis of observational studies

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Abstract

Purpose

To investigate the association between gastrectomy and risk of pancreatic cancer (PaC).

Methods

We identified eligible studies in Medline and EMBASE up to 11 February 2012 and the reference lists of original studies and review articles on this topic. Summary relative risks with their 95 % confidence intervals were calculated with a random-effects model. Between-study heterogeneity was assessed using Cochran Q and I 2 statistics.

Results

Fifteen studies (11 case–control studies and 4 cohort studies) met eligibility criteria. The current data suggest that gastrectomy is associated with a 54 % excess risk of PaC (SRRs = 1.54; 95 % CI, 1.25–1.90; test for heterogeneity Q = 17.94, p < 0.001, I 2 = 22 %). There was no publication bias in the present meta-analysis.

Conclusion

A significant increased risk of PaC exists in patients who have undergone gastrectomy, particularly those receiving Billroth II resection with a long postoperative interval.

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Abbreviations

PaC:

Pancreatic cancer

OR:

Odds ratio

RR:

Relative risk

HR:

Hazard ratio

SRRs:

Summary relative risks

CI:

Confidence intervals

BMI:

Body mass index

DM:

Diabetes mellitus

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Acknowledgments

This work was supported by a grant from the National Natural Science Foundation of China (No. 81000917).

Conflict of interest

There is no potential conflict of interest among all authors.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan-Jiang Xi Road, Guangzhou, 510120, China

    Yuanfeng Gong, Quanbo Zhou, Yu Zhou, Qing Lin, Bing Zeng & Rufu Chen

  2. Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan-Jiang Xi Road, Guangzhou, 510120, China

    Zhihua Li

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  1. Yuanfeng Gong
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  2. Quanbo Zhou
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  3. Yu Zhou
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Corresponding author

Correspondence to Rufu Chen.

Additional information

Yuanfeng Gong and Quanbo Zhou contributed equally to this study and should share first authorship together.

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Gong, Y., Zhou, Q., Zhou, Y. et al. Gastrectomy and risk of pancreatic cancer: systematic review and meta-analysis of observational studies. Cancer Causes Control 23, 1279–1288 (2012). https://doi.org/10.1007/s10552-012-0005-z

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