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Factors associated with Type I and Type II endometrial cancer

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Abstract

Objective

We investigated risk factors for Type II (n = 176) vs. Type I (n = 1,576) endometrial cancer (EC) in cases treated at Magee-Womens Hospital between 1996 and 2008.

Methods

Clinical data were available from the University of Pittsburgh Medical Center (UPMC) Network Cancer Registry. Logistic regression was used to estimate the adjusted odds of having Type II EC vs. Type I EC. Risk factors of interest in this analysis were age, race, body mass index (BMI), year of diagnosis, parity, menopausal status, and history of additional primary tumors.

Results

Relative to women with Type I EC, women with Type II EC were more likely to be older at diagnosis (OR: 1.03 per 1 year increase in age, 95% CI 1.01–1.05), of non-white race (OR: 2.95, 95% CI 1.66–5.27), have a history of additional primary tumors (OR: 1.56, 95% CI 1.05–2.32), and less likely to be obese (OR: 0.45, 95% CI 0.29–0.70).

Conclusion

In this large retrospective cohort of patients with EC, the striking difference in risk factors associated with Type II vs. Type I tumors suggests that these subtypes represent different disease entities that require different treatment modalities. Currently, Type II cases have a significantly worse prognosis compared to Type I. Further characterization of risk factors associated with developing Type II tumors is needed to prevent this aggressive malignancy.

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Acknowledgments

We wish to thank the University of Pittsburgh Medical Center (UPMC) Registry Information Services (RIS) team, especially Sharon Winters and Louise Mazur, for their help with procuring the data for this study as well as explaining technical details regarding the registry.

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Authors and Affiliations

  1. Division of Cancer Prevention and Population Science, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Suite 4-C, Pittsburgh, PA, 15232, USA

    Ashley S. Felix, Joel L. Weissfeld & Faina Linkov

  2. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 15261, USA

    Ashley S. Felix, Joel L. Weissfeld & Faina Linkov

  3. Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 15261, USA

    Roslyn A. Stone

  4. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA

    Robert Bowser

  5. Department of Pathology, Magee-Womens Hospital of UPMC Health System, 300 Halket St, Pittsburgh, PA, 15213, USA

    Mamatha Chivukula

  6. Department of Obstetrics and Gynecologic Oncology, Magee-Womens Hospital of UPMC Health System, 300 Halket St, Pittsburgh, PA, 15213, USA

    Robert P. Edwards

Authors
  1. Ashley S. Felix
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  2. Joel L. Weissfeld
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  3. Roslyn A. Stone
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  5. Mamatha Chivukula
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  7. Faina Linkov
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Corresponding author

Correspondence to Ashley S. Felix.

Additional information

This research was supported by a National Institutes of Health grant R25-CA057703.

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Felix, A.S., Weissfeld, J.L., Stone, R.A. et al. Factors associated with Type I and Type II endometrial cancer. Cancer Causes Control 21, 1851–1856 (2010). https://doi.org/10.1007/s10552-010-9612-8

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  • DOI: https://doi.org/10.1007/s10552-010-9612-8

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