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Risk patterns of multiple myeloma in Los Angeles County, 1972–1999 (United States)

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Abstract

Objective

To describe the risk patterns of multiple myeloma in Los Angeles County (LAC).

Methods

Incident multiple myeloma cases diagnosed from 1972 to 1999 were ascertained by the population-based cancer registry for LAC. Average annual age-specific and age-adjusted incidence rates (AAIR), standardized to the 2000 US census age distribution, were calculated using age-, race-, sex- and socioeconomic status (SES)-specific denominators estimated for all years from US census data for 1970, 1980 and 1990. Odds ratios (ORs) for risk by birthplace and religion were estimated using multivariate logistic regression, comparing multiple myeloma patients with other cancer patients.

Results

All groups experienced increasing incidence with age; African-Americans experienced the steepest increase which began a decade earlier compared to other groups. Overall incidence rates were 50% higher among males (n = 4,692) than females (n = 4,343) (< 0.05). AAIRs were highest for African-Americans, followed by Spanish-surnamed whites (SSW), non-Spanish-surnamed whites (NSSW), Filipinos and other Asian groups. Among African-Americans, incidence rates increased with increasing SES. US-born SSW had 14% lower risk compared to non-US born SSW (OR = 0.86, 95% confidence interval [CI] = 0.74–0.99]. Jews had an 11% higher risk compared to Protestants (OR = 1.11; 95% CI = 0.99–1.24).

Conclusion

Risk patterns suggest a role for both environmental and genetic factors.

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Acknowledgments

The collection of cancer incidence data used in this publication was supported by the California Department of Health Services as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885. The ideas and opinions expressed herein are those of the author, and no endorsement by the State of California, Department of Health Services is intended or should be inferred. This publication was also supported by grant number U55/CCU921930-02 from the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the federal government. This project has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, under Contract No. N01-PC-35139.

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Correspondence to Wendy Cozen.

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Gebregziabher, M., Bernstein, L., Wang, Y. et al. Risk patterns of multiple myeloma in Los Angeles County, 1972–1999 (United States). Cancer Causes Control 17, 931–938 (2006). https://doi.org/10.1007/s10552-006-0030-x

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  • DOI: https://doi.org/10.1007/s10552-006-0030-x

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