Abstract
Objective
To describe the risk patterns of multiple myeloma in Los Angeles County (LAC).
Methods
Incident multiple myeloma cases diagnosed from 1972 to 1999 were ascertained by the population-based cancer registry for LAC. Average annual age-specific and age-adjusted incidence rates (AAIR), standardized to the 2000 US census age distribution, were calculated using age-, race-, sex- and socioeconomic status (SES)-specific denominators estimated for all years from US census data for 1970, 1980 and 1990. Odds ratios (ORs) for risk by birthplace and religion were estimated using multivariate logistic regression, comparing multiple myeloma patients with other cancer patients.
Results
All groups experienced increasing incidence with age; African-Americans experienced the steepest increase which began a decade earlier compared to other groups. Overall incidence rates were 50% higher among males (n = 4,692) than females (n = 4,343) (p < 0.05). AAIRs were highest for African-Americans, followed by Spanish-surnamed whites (SSW), non-Spanish-surnamed whites (NSSW), Filipinos and other Asian groups. Among African-Americans, incidence rates increased with increasing SES. US-born SSW had 14% lower risk compared to non-US born SSW (OR = 0.86, 95% confidence interval [CI] = 0.74–0.99]. Jews had an 11% higher risk compared to Protestants (OR = 1.11; 95% CI = 0.99–1.24).
Conclusion
Risk patterns suggest a role for both environmental and genetic factors.
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References
Morgan G, Davies F, Linet M (2002) Myeloma aetiology and epidemiology. Biomed Pharmacother 56:223–234
Kosmas C, Stamatopoulos K, Stavroyianni N, et al (2000) Origin and diversification of the clonogenic cell in multiple myeloma: lessons from the immunoglobulin repertoire. Leukemia 14:1718–1726
Sirohi B, Powles R (2004) Multiple myeloma. Lancet 363:875–887
Herrinton L, Weiss N, Olshan A (1996) Multiple myeloma. In: Schottenfeld D, Fraumeni JJ (eds) Cancer epidemiology and prevention. Oxford University Press, New York, pp 946–970
Bergasel D (1995) The incidence and epidemiology of plasma cell neoplasms. Stem Cells 13(supplement 2):1–9
Miller B, Kolonel L, Bernstein L, et al (1996) Racial/ethnic patterns of cancer in the United States 1988–1992. National Cancer Institute, Bethesda, MD. NIH Pub. No. 96-4104
Koessel S, Theis M, Vaughan T, et al (1996) Socioeconomic status and the incidence of multiple myeloma. Epidemiology 7:1–3
Pasqualetti P, Casale R, Collacciani A, Colantonio D (1990) Work activities and the risk of multiple myeloma: a case–control study. Med Lav 81:308–319
Baris D, Brown L, Silverman D, et al (2000) Socioeconomic status and multiple myeloma among US blacks and whites. Am J Public Health 90(8):1277–1281
Johnston J, Grufferman S, Bourguet C, Delzell E, Delong E, Cohen H (1985) Socioeconomic status and risk of multiple myeloma. Epidemiol Commun Health J 39:175–178
Figgs L, Dosemeci M, Blair A (1994) Risk of multiple myeloma by occupation and industry among men and women: a 24-state death certificate study. J Occup Med 36:1210–1221
Mack T (1977) Cancer surveillance program in Los Angeles County. Nat Cancer Inst Monogr 47:99–101
Fritz A, Percy C, Jack A, et al (eds) (2000) International classification of diseases for oncology. 3rd edn. World Health Association, Geneva
Boyle P, Parkin D (1991) Statistical methods for registries. International Agency for Research on Cancer, Lyon, France
Liu L, Deapen D, Bernstein L (1998) Socioeconomic status and cancer of the female breast and reproductive organs: a comparison across racial/ethnic population in Los Angeles County, California (United states). Cancer Causes Controls 9:369–380
Riedel D, Pottern L (1992) The epidemiology of multiple myeloma. Hematol Oncol Clin N Am 6(2):225–247
Hernandez J, Land K, McKenna R (1995) Leukemias, myeloma and other lymphoreticular neoplasms. Cancer 75(1 Suppl):381–394
Walker B, Figgs L, Zahm S (1995) Differences in cancer incidence, mortality, and survival between African Americans and whites. Environ Health Perspect 103(supplement 8):275–281
Benjamin M, Reddy S, Brawley O (2003) Myeloma and race: a review of the literature. Cancer Metastatsis Rev 22:87–93
Grulich A, Swerdlow A, Head J, Marmot M (1992) Cancer mortality in African and Caribbean migrants to England and Wales. Br J Cancer 66(5):905–911
Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB (eds) (2002) Cancer in five continents; IARC Scientific Publications No. 155. International Agency for Research on Cancer, Lyon, France
Nossent J, Winkel C, van Leeuwen J (1993) Multiple myeloma in the Afro-Caribbean population of Curacao. Neth J Med 43(5–6):210–214
Besson C, Gonin C, Brebion A, Delaunay C, Panelatti G, Plumelle Y (2001) Incidence of hematological malignancies in Martinique, French West Indies, overrepresentation of multiple myeloma and adult T cell leukemia/lymphoma. Leukemia 15:828–831
Cozen W, Katz J, Mack T (1992) Risk patterns of Hodgkin’s disease in Los Angeles vary by cell type. Cancer Epidemiol Biomarkers Preven 1:261–268
Gale R, Cozen W, Goodman M, Wang F, Bernstein L (2000) Decreased chronic lymphocytic leukemia incidence in Asians in Los Angeles County. Leuk Res 24:665–669
Mack T, Walker A, Mack W, Bernstein L (1985) Cancer in hispanics in Los Angeles County. Nat Cancer Inst Monogr 69:99–104
Shulman G, Jacobson R (1980) Immunocytoma in black and white South Africans. Trop Geogr Med 32(2):112–117
Devesa S, Silverman D, Young JJ, et al (1987) Cancer incidence and mortality trends among whites in the United States, 1947–84. JNCI 79(4):701–710
Boffetta P, Stellman S, Garfinkel L (1989) A case-control study of multiple myeloma nested in the American Cancer Society prospective study. Int J Cancer 43:554–559
Bernstein L, Newton P, Ross R (1889) Epidemiology of hairy cell leukemia in Los Angeles County. Cancer Res 50(12):3605–3609
Mack T, Berkel J, Bernstein L, Mack W (1985) Religion and cancer in Los Angeles County. Nat Cancer Inst Monogr 69:235–245
Kishimoto T (2003) Interleukin-6 (IL-6). In: Thomson A, Lotze M (eds) The cytokine handbook. Academic Press, London pp 281–304
Lauta V (2003) A review of the cytokine network in multiple myeloma: diagnostic, prognostic, and therapeutic implications. Cancer 97(10):2440–2552
Michalaki V, Syrigos K, Charles P, Waxman J (2004) Serum levels of IL-6 and TNF-alpha correlate with clinicopathological features and patient survival in patients with prostate cancer. BrJ Cancer 90(12):2312–2316
Martin A, Athanasiadis G, Greshock J, et al (2003) Population frequencies of single nucleotide polymorphisms (SNPs) in immuno-modulatory genes. Human Hered 55:171–176
Delaney N, Esquenazi V, Lucas D, Zachary A, Leffell M (2004) TNF-alpha, TFG-beta, IL-10, IL-6, and INF-gamma alleles among African Americans and Cuban Americans. Report of the ASHI minority workshops: Part IV. Human Immunol 65:1413–1419
Hoffmann S, Stanley E, Cox E, et al (2002) Ethnicity greatly influences cytokine gene polymorphism distribution. Am J Transplant 2:560–567
Lim C, Zheng S, Kim Y, et al (2002) The –174 G to C polymorphism of interleukin-6 gene is very rare in koreans. Cytokine 19:52–54
Zheng C, Huang D, Bergenbrant S, et al (2000) Interleukin 6, tumour necrosis factor [alpha], interleukin 1 [beta] and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma. Br J Haematol 109(1):39–45
Dring A, FE Davis, Rollinson S, et al (2001) Interleukin 6, tumour necrosis factor [alpha] and lymphotoxin [alpha] polymorphisms in monoclonal gammopathy of uncertain significance and multiple myeloma. Br J Haematol 112(1):249–250
Iakupova E, Grinchuk O, Kalimullina D, et al (2003) Molecular genetic analysis of the interleukin 6 and tumor necrosis factor alpha gene polymorphisms in multiple myeloma. Mol Biol 37(3):420–424
Mazur G, Bogunia-Kubik K, Wrobel T, et al (2005) IL-6 and IL-10 promoter gene polymorphisms do not associate with the susceptibility for multiple myeloma. Immunol Lett 96:241–246
Peng B, Hodge D, Thomas S, et al (2005) Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. J Biol Chem 280(6):4182–4187
Velangi M, Matheson E, Morgan G, et al (2004) DNA mismatch repair pathway defects in the pathogenesis and evolution of myeloma. Carcinogenesis 25(10):1795–1803
Acknowledgments
The collection of cancer incidence data used in this publication was supported by the California Department of Health Services as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885. The ideas and opinions expressed herein are those of the author, and no endorsement by the State of California, Department of Health Services is intended or should be inferred. This publication was also supported by grant number U55/CCU921930-02 from the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the federal government. This project has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, under Contract No. N01-PC-35139.
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Gebregziabher, M., Bernstein, L., Wang, Y. et al. Risk patterns of multiple myeloma in Los Angeles County, 1972–1999 (United States). Cancer Causes Control 17, 931–938 (2006). https://doi.org/10.1007/s10552-006-0030-x
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DOI: https://doi.org/10.1007/s10552-006-0030-x