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Case report and review of the literature: Secretory breast cancer in a 13-year-old boy—10 years of follow up

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Abstract

Carcinoma of the breast is very rare in childhood, accounting for less than 1% of all childhood malignancies and is especially rare in boys. Delay in diagnosis and treatment in children with breast cancer may occur because surgeons are very reluctant to perform biopsies on the developing breast, since these can cause future deformity. We report a case of male secretory breast carcinoma in a 13-year-old boy. Radical mastectomy was performed followed by chemotherapy. The patient is free of disease after 10 years. Secretory breast carcinoma (SBC) is the commonest type of breast carcinoma in children. In this article, we discuss the diagnosis and treatment options for breast cancer among children as well as features of SBC, based on a literature review.

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References

  1. Gallager HS (1984) Pathologic types of breast cancer: their prognoses. Cancer 53:623–629

    Article  PubMed  CAS  Google Scholar 

  2. Herz H, Cooke B, Goldstein D (2000) Metastatic secretory breast cancer. Non-responsiveness to chemotherapy: case report and review of the literature. Ann Oncol 11:1343–1347

    Article  PubMed  CAS  Google Scholar 

  3. McDivitt RW, Stewart FW (1966) Breast carcinoma in children. JAMA 195:144–146

    Article  Google Scholar 

  4. Lamovec J, Bracko M (1994) Secretory carcinoma of the breast: light microscopical, immunohistochemical flow cytometric study. Mod Pathol 7:475–479

    PubMed  CAS  Google Scholar 

  5. Oberman HA, Stephens PJ (1972) Carcinoma of the breast in childhood. Cancer 30:470–474

    Article  PubMed  CAS  Google Scholar 

  6. Tavassoli FA, Norris HJ (1980) Secretory carcinoma of the breast. Cancer 45:2404–2413

    Article  PubMed  CAS  Google Scholar 

  7. Rosen PP, Cranor M (1991) Secretory carcinoma of the breast. Arch Pathol Lab Med 115:141–144

    PubMed  CAS  Google Scholar 

  8. Byrne MP, Fahey MM, Gosselaw JG (1973) Breast cancer with axillary metastasis in a eight and one-half-year-old girl. Cancer 31:726–728

    Article  PubMed  CAS  Google Scholar 

  9. Akhtar M, Robinson C, Ashraf Ali M, Godwin J (1983) Secretory carcinoma of the breast in adults. Light and electron microscopic study of three cases and review of the literature. Cancer 51:2245–2254

    Article  PubMed  CAS  Google Scholar 

  10. Krausz T, Jenkins D, Grontoft O, Pollock DJ, Azzopardi JG (1989) Secretory carcinoma of the breast in adults: emphasis on late recurrence and metastasis. Histopathology 14:25–36

    Article  PubMed  CAS  Google Scholar 

  11. Khalbuss WE (2005) Cytomorphology of rare malignant tumors of the breast. Clin Lab Med 25(4):761–775

    Article  PubMed  Google Scholar 

  12. de Bree E, Askoxylakis J, Giannikaki E, Chroniaris N, Sanidas E, Tsiftsis DD (2002) Secretory carcinoma of the male breast. Ann Surg Oncol 9:663–667

    Article  PubMed  Google Scholar 

  13. Szántó J, András C, Tsakiris J, Gomba S, Szentirmay Z, Bánlaki S, Szilágyi I, Kiss C, Antall P, Horváth Á, Lengyel L, Castiglione-Gertsch M (2004) Secretory breast cancer in a 7.5-year old boy. Breast 13:439–442

    Article  PubMed  Google Scholar 

  14. Diallo R, Schaefer KL, Bankfalvi A, Decker T, Ruhnke M, Wülfing P, jackisch C, Luttges J, Sorensen PH, Singh M, Poremba C (2003) Secretory carcinoma of the breast: a distinct variant of invasive ductal carcinoma assessed by comparative genomic hybridization and immunohistochemistry. Hum Pathol 34:1299–1305

    Article  PubMed  CAS  Google Scholar 

  15. Costa NM, Rodrigues H, Pereira H, Pardal F, Matos E (2004) Secretory breast carcinoma–case report and review of the medical literature. Breast 13:353–355

    Article  PubMed  CAS  Google Scholar 

  16. García CJ, Espinoza A, Dinamarca V, Navarro O, Daneman A, García H, Cattani A (2000) Breast US in children and adolescents. Radiographics 20(6):1605–1612

    PubMed  Google Scholar 

  17. Weinstein SP, Conant DF, Orel SG, Zuckerman JA, Bellah R (2000) Spectrum of US findings in pediatric and adolescent patients with palpable breast masses. Radiographics 20(6):1613–1621

    PubMed  CAS  Google Scholar 

  18. Chung EM, Cube R, Hall GF, González C, Stocker FT, Glassman LM (2009) Breast masses in children and adolescents: radiologic–pathologic correlation. Radiographics 29:907–931

    Article  PubMed  Google Scholar 

  19. Woto-Gaye G, Kasse AA, Dieye Y, Toure P, Demba Ndiaye P (2004) Secretory breast carcinoma in a man. A case report with rapid evolution unfavorable. Ann Pathol 24(5):432–435

    Article  PubMed  Google Scholar 

  20. Kavalakat AJ, Covilakam RK, Culas TP (2004) Secretory carcinoma of breast in a 17-year-old male. World J Surg Oncol 2:17

    Article  PubMed  Google Scholar 

  21. Serour F, Gilad A, Kopolovic J, Krispin M (1990) Secretory breast cancer in childhood and adolescence: report of a case and review of the literature. Med Pediatr Oncol 20:341–344

    Article  Google Scholar 

  22. Simpson JS, Barson AJ (1969) Breast tumours in infants and children: a 40-year review of cases at a children’s hospital. Can Med Assoc J 101:100–102

    PubMed  CAS  Google Scholar 

  23. Karl SR, Ballantine TVN, Zaino R (1985) Juvenile secretory carcinoma of the breast. J Pediatr Surg 20:368–371

    Article  PubMed  CAS  Google Scholar 

  24. Roth JA, Discafani C, O’Malley M (1988) Secretory breast carcinoma in a man. Am J Surg Pathol 12:150–154

    Article  PubMed  CAS  Google Scholar 

  25. Pohar-Marinsek Z, Golouh R (1994) Secretory breast carcinoma in a man diagnosed by fine needle aspiration biopsy. A case report. Acta Cytol 38:446–450

    PubMed  CAS  Google Scholar 

  26. Kameyama K, Mukai M, Iri H, Kuramochi S, Yamazaki K, Ikeda Y, Hata J (1998) Secretory carcinoma of the breast in a 51-year old male. Pathol Int 48:994–997

    Article  PubMed  CAS  Google Scholar 

  27. Kuwabara H, Yamane M, Okada S (1998) Secretory breast carcinoma in a 66-year-old man. J Clin Pathol 51:545–547

    Article  PubMed  CAS  Google Scholar 

  28. Vesoulis Z, Kashkari S (1998) Fine needle aspiration of Secretory breast carcinoma resembling lactational changes. A case report. Acta Cytol 42:1032–1036

    Article  PubMed  CAS  Google Scholar 

  29. Yildirim E, Turban N, Pak I, Berberoglu U (1999) Secretory breast carcinoma in a boy. Eur J Surg Oncol 25:98–99

    PubMed  CAS  Google Scholar 

  30. Chevalier A, Boissy C, Rampal A, Soller C, Ture-Carell C, Thyss A, Michielis JF (1999) Secretory carcinoma of the breast. Report of a case in a 9-year-old boy. Clin Exp Pathol 47:88–91

    Google Scholar 

  31. Bhagwandeen BS, Fenton L (1999) Secretory carcinoma of the breast in a nine year old boy. Pathology 31(2):166–168

    Article  PubMed  CAS  Google Scholar 

  32. Titus J, Sillar RW, Fenton LE (2000) Secretory breast carcinoma in a 9-year old boy. Aust N Z J Surg 70:144–146

    Article  PubMed  CAS  Google Scholar 

  33. Alenda C, Aranda FI, Seguí FJ, Laforga J (2005) Secretory carcinoma of the male breast: correlation of aspiration cytology and pathology. Diagn Cythopathol 32(1):47–50

    Article  Google Scholar 

  34. Arce C, Cortes-Padilla D, Huntsman DG, Miller MA, Dueñnas-Gonzalez A, Alvarado A, Pérez V, Gallardo-Rincón D, Lara-Medina F (2005) Secretory carcinoma of the breast containing the ETV6-NTRK3 fusion gene in a male: case report and review of the literature. World J Surg Oncol 3:35

    Article  PubMed  CAS  Google Scholar 

  35. Grabellus F, Worm K, Willruth A, Schmitz KJ, Otterbach F, Baba HA, Kimmig R, Metz KA (2005) ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexual. Breast 14:71–74

    Article  PubMed  CAS  Google Scholar 

  36. Iglesias B, Monteagudo B, Rouco JS, Anton I (2009) Secretory breast carcinoma in a 63-year-old man. J Cutan Pathol 36(Suppl 1):86–88

    Article  PubMed  Google Scholar 

  37. Paeng MH, Choi HY, Sung SH, Moon BI (2003) Secretory carcinoma of the breast. J Clin Ultrasound 31(8):425–429

    Article  PubMed  Google Scholar 

  38. Gupta RK, Kenwright D, Naran S, Lallu S, Fauck R (2000) Fine needle aspiration cytodiagnosis of secretory carcinoma of the breast. Cytopathology 11:496–502

    Article  PubMed  CAS  Google Scholar 

  39. Murphy JJ, Morzaria S, Gow KW, Magee JF (2000) Breast cancer in a 6-year-old child. J Pediatr Surg 35:765–767

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Priscila Silva Marshall.

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Cabello, C., Alvarenga, M., Alvarenga, C.A. et al. Case report and review of the literature: Secretory breast cancer in a 13-year-old boy—10 years of follow up. Breast Cancer Res Treat 133, 813–820 (2012). https://doi.org/10.1007/s10549-011-1869-4

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  • DOI: https://doi.org/10.1007/s10549-011-1869-4

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