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TGF-β1 29T/C polymorphism and breast cancer risk: a meta-analysis involving 25,996 subjects

  • Epidemiology
  • Published:
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Abstract

Transforming growth factor β1 (TGF-β1) is a cytokine, playing an important role in controlling cell proliferation and differentiation involved in breast cancer. It was reported the 29T/C polymorphism in TGF-β1 has been implicated in breast cancer risk. However, studies on the association between this polymorphism and breast cancer remain conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 10,341 cases and 15,655 controls from fifty published case-control studies was performed. Our analysis suggested that 29T/C has no association with a trend of breast cancer risk when using both dominant [odds ratio (OR) = 1.01, 95% confidence intervals (CI) 0.96–1.07] and recessive models (OR = 0.98, 95% CI 0.89–1.08) to analyze the data. In ethnic subgroups analysis, 29T/C also did not appear to be risk factors for breast cancer. However, larger scale primary studies are required to further evaluate the interaction of TGF-β1 29T/C polymorphism and breast cancer risk in specific populations.

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Acknowledgements

This study was supported by National 973 Programs of China grant [2004CB518605 to L.Y.], the National 863 project of China [2006AA020501 to L.Y.],the National Key Sci-Tech Special Project of China [2008ZX10002-020], the Project of the Shanghai Municipal Science and Technology Commission [03dz14086], and the National Natural Science foundation of China [30024001, 30771188].

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Authors and Affiliations

  1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People’s Republic of China

    Yongsheng Huang, Ji Qian & Long Yu

  2. Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, W325, Chicago, IL, 60637, USA

    Yongsheng Huang, Binghui Li & Jingtian Xie

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  1. Yongsheng Huang
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  2. Binghui Li
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  3. Ji Qian
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  4. Jingtian Xie
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  5. Long Yu
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Correspondence to Yongsheng Huang or Long Yu.

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Huang, Y., Li, B., Qian, J. et al. TGF-β1 29T/C polymorphism and breast cancer risk: a meta-analysis involving 25,996 subjects. Breast Cancer Res Treat 123, 863–868 (2010). https://doi.org/10.1007/s10549-010-0796-0

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  • DOI: https://doi.org/10.1007/s10549-010-0796-0

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