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TGFB1 L10P polymorphism is associated with breast cancer susceptibility: evidence from a meta-analysis involving 47,817 subjects

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Published data on the association between TGFB1 L10P polymorphism and breast cancer risk are inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of 30 studies including 20,401 cases and 27,416 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with TGFB1 10P allele when all studies were pooled into the meta-analysis (LP vs. LL: OR = 1.046, 95% CI = 1.003–1.090; dominant model: OR = 1.052, 95% CI = 1.012–1.095). In the subgroup analysis by ethnicity, statistically significantly elevated risk was found in Caucasians (dominant model: OR = 1.045, 95% CI = 1.001–1.091). When stratified by study design, statistically significantly elevated risk was found based on population-based studies (dominant model: OR = 1.076, 95% CI = 1.019–1.136). In conclusion, this meta-analysis suggests that the TGFB1 10P allele may be a low-penetrant risk factor for developing breast cancer. However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding.

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Authors and Affiliations

  1. Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China

    Li-Xin Qiu, Kai Xue, Jian Zhang & Xi-Chun Hu

  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

    Li-Xin Qiu, Kai Xue, Jian Zhang & Xi-Chun Hu

  3. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China

    Lei Yao

  4. Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China

    Chen Mao

  5. Department of Geriatrics, First Affiliated Hospital, Nanjing Medical University, Nanjing, China

    Bo Chen

  6. Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China

    Ping Zhan

  7. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China

    Hui Yuan

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  1. Li-Xin Qiu
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  2. Lei Yao
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  3. Chen Mao
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  4. Bo Chen
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  5. Ping Zhan
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  6. Kai Xue
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  7. Jian Zhang
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  8. Hui Yuan
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  9. Xi-Chun Hu
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Corresponding author

Correspondence to Xi-Chun Hu.

Additional information

Li-Xin Qiu and Lei Yao have contributed equally to this work and should be considered as co-first authors.

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Qiu, LX., Yao, L., Mao, C. et al. TGFB1 L10P polymorphism is associated with breast cancer susceptibility: evidence from a meta-analysis involving 47,817 subjects. Breast Cancer Res Treat 123, 563–567 (2010). https://doi.org/10.1007/s10549-010-0781-7

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  • DOI: https://doi.org/10.1007/s10549-010-0781-7

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