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HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case–control analyses

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Summary

Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case–control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.

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Authors and Affiliations

  1. Department of Epidemiology, School of Public Health, University of North Carolina, CB #7435, Chapel Hill, NC, 27599-7435, USA

    Robert C. Millikan

  2. Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Amanda J. Hummer & Colin B. Begg

  3. Mount Sinai Medical Center, New York, NY, USA

    Mary S. Wolff

  4. Nagoya University Graduate School of Medicine, Nagoya, Japan

    Asahi Hishida

Authors
  1. Robert C. Millikan
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  2. Amanda J. Hummer
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  3. Mary S. Wolff
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  4. Asahi Hishida
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  5. Colin B. Begg
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Correspondence to Robert C. Millikan.

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Millikan, R.C., Hummer, A.J., Wolff, M.S. et al. HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case–control analyses. Breast Cancer Res Treat 89, 309–312 (2005). https://doi.org/10.1007/s10549-004-2171-5

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  • DOI: https://doi.org/10.1007/s10549-004-2171-5

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