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Biodegradation of bisphenol A and its halogenated analogues by Cunninghamella elegans ATCC36112

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Abstract

Bisphenol A and its halogenated analogues are commonly used industrial chemicals with strong toxicological effects over many organisms. In this study, metabolic fate of bisphenol A and its halogenated analogues were evaluated with Cunninghamella elegans ATCC36112. Bisphenol A and related analogues were rapidly transformed into several metabolites by C. elegans within 2–4 days. Detailed analysis of metabolites reveals that both phase I and II metabolism occurred in C. elegans. Cytochrome P450-dependent hydroxylation was observed in BPA. However, major reaction with bisphenol A and analogues with 1-2 halogen atoms were the formation of glucose-conjugate, not being inhibited by cytochrome P450 inhibitor. Overall metabolic rates decreased with increasing number of substitution at 2- and 6-position of BPA structures, which may be consequences of limited bioavailability or steric hindrance to conjugate-forming reaction. Information from the current study will provide detailed insights over the fungal metabolism of BPA and analogues.

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  1. Young Soo Keum

    Present address: Konkuk University, 1 Hwayan-dong, Gwangjin-gu, Seoul, 143-701, Republic of Korea

Authors and Affiliations

  1. Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak-ro, Silim-dong, Gwanak-Gu, Seoul, 151-742, Republic of Korea

    Young Soo Keum, Hye Ri Lee, Hee Won Park & Jeong-Han Kim

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  1. Young Soo Keum
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  2. Hye Ri Lee
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  3. Hee Won Park
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Correspondence to Jeong-Han Kim.

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Keum, Y.S., Lee, H.R., Park, H.W. et al. Biodegradation of bisphenol A and its halogenated analogues by Cunninghamella elegans ATCC36112. Biodegradation 21, 989–997 (2010). https://doi.org/10.1007/s10532-010-9358-8

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  • DOI: https://doi.org/10.1007/s10532-010-9358-8

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