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A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin

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Abstract

Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.

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Authors and Affiliations

  1. Department of Microbiology, School of Biotechnology & Biomedical Science and Bio-Health Product Research Center, Inje University, Gimhae, Gyungnam, 621–749, S. Korea

    Hee Jung Ji, Hee Kyoung Yeo, Nam Hee Lee, Jung Suk Hwang, Kyung Ah Koo & Hyun Joo Youn

  2. Department of Biology, College of Natural Sciences, Changwon National University, Changwon, 641-773, S. Korea

    Seon Woo Cheong, Joo Hung Park, Gap Soo Oh & Chun Sik Yoon

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  1. Hee Jung Ji
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  2. Hee Kyoung Yeo
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  3. Nam Hee Lee
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  4. Jung Suk Hwang
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  5. Kyung Ah Koo
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  6. Seon Woo Cheong
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  7. Joo Hung Park
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  8. Gap Soo Oh
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  9. Chun Sik Yoon
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  10. Hyun Joo Youn
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Corresponding author

Correspondence to Hyun Joo Youn.

Additional information

Revisions requested 29 October 2004; Revisions received 10 December 2004

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Ji, H.J., Yeo, H.K., Lee, N.H. et al. A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin. Biotechnol Lett 27, 253–257 (2005). https://doi.org/10.1007/s10529-004-8294-2

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  • DOI: https://doi.org/10.1007/s10529-004-8294-2

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