Intraperitoneal injection of β-endorphin in doses of 1, 0.01, and 0.0005 μg/kg under conditions of systemic immunization increased the count of antibody-producing cells in the spleen and the titer of anti-erythrocyte antibodies in the plasma of experimental animals. Intraperitoneal β-endorphin stimulated proliferative activity of splenocytes in mice in the presence of both B- and T-cell mitogen, did not change the production of IFN-γ, reduced the level of IL-2, and stimulated the secretion of IL-4, the main Th2-polarizing factor.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 11, pp. 526-530, November, 2011
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Gein, S.V., Baeva, T.A., Nebogatikov, V.O. et al. β-Endorphin Effects on Antibody Production, Proliferation, and Secretion of Th1/Th2 Cytokines In Vivo . Bull Exp Biol Med 152, 595–599 (2012). https://doi.org/10.1007/s10517-012-1584-0
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DOI: https://doi.org/10.1007/s10517-012-1584-0