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Heat Shock Protein HSP70 Increases the Resistance of Cortical Cells to Glutamate Excitotoxicity

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Preincubation of cultured slices of the olfactory cortex of rat brain with heat shock protein in a concentration of 1 µg/ml protected the pre- and postsynaptic mechanisms of glutamatergic synaptic transmission from glutamate excitotoxicity (50 mM) inducing blockade of excitatory postsynaptic function and reducing presynaptic processes. It was hypothesized that heat shock protein protects AMPA and NMDA receptor-mediated processes.

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REFERENCES

  1. A. A. Mokrushin, L. I. Pavlinova, I. V. Guzhova, et al., Dokl. Akad. Nauk, No. 3, 419–422 (2004).

  2. S. S. Musjashchikova and A. A. Mokrushin, Izv. Akad. Nauk SSSR. Ser. Biol., No. 3, 458–461 (1989).

  3. D. W. Choi, Neuron, 1, No.8, 623–634 (1988).

    Article  PubMed  Google Scholar 

  4. N. C. Danbolt, Prog. Neurobiol., 44, No.4, 377–396 (1994).

    Article  PubMed  Google Scholar 

  5. K. A. Hossmann, Brain Pathol., 4, No.1, 23–36 (1994).

    PubMed  Google Scholar 

  6. M. J. Hudspith, Br. J. Anaesth., 78, No.6, 731–747 (1997).

    PubMed  Google Scholar 

  7. R. N. Ichord, M. V. Jonston, and R. J. Traystman, Develop. Brain. Res., 128, 139–148 (2001).

    Article  Google Scholar 

  8. C. Ikonomidou and L. Turski, Lancet Neurol., 1, No.6, 383–386 (2002).

    Article  PubMed  Google Scholar 

  9. T. Kubo, T. Yokoi, Y. Hagiwara, et al., Brain Res., 54, 413–419 (2001).

    Google Scholar 

  10. E. K. Michaelis, Prog. Neurobiol., 54, 369–415 (1988).

    Article  Google Scholar 

  11. T. P. Obrenovitch and J. Urenjak, Ibid., 51, No.1, 39–87 (1997).

    Article  PubMed  Google Scholar 

  12. R. Sattler and M. Tymianski, J. Mol. Med., 78, 3–13 (2000).

    Article  PubMed  Google Scholar 

  13. J. F. Stover and A. W. Unterberg, Brain Res., 875, Nos. 1–2, 51–55 (2000).

    Article  PubMed  Google Scholar 

  14. K. Takagi, M. D. Ginsberg, N. Y. Globus, et al., J. Cerebr. Blood Flow Metab., 13, No.4, 575–585 (1993).

    Google Scholar 

  15. M. Yassin and C. N. Scholfield, Br. J. Pharmacol., 111, No.4, 1221–1227 (1994).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Russia

    A. A. Mokrushin & L. I. Pavlinova

  2. B. P. Konstantinov St. Petersburg Institute of Nuclear Researches, Russian Academy of Sciences, Gatchina, Russia

    A. Yu. Plekhanov

Authors
  1. A. A. Mokrushin
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  2. L. I. Pavlinova
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  3. A. Yu. Plekhanov
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 7, pp. 4–8, July, 2005

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Mokrushin, A.A., Pavlinova, L.I. & Plekhanov, A.Y. Heat Shock Protein HSP70 Increases the Resistance of Cortical Cells to Glutamate Excitotoxicity. Bull Exp Biol Med 140, 1–5 (2005). https://doi.org/10.1007/s10517-005-0396-x

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  • DOI: https://doi.org/10.1007/s10517-005-0396-x

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