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Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer

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Abstract

It has recently become clear the role played by alterations in apoptosis during the development of several chronic diseases (i.e. inflammatory, neurodegenerative and neoplastic pathologies). For this reason, the research for possible therapeutic strategies involving the modulation of the apoptotic pathways has attracted considerable interest in the past few years. In particular, it has been shown that apoptosis may be induced or inhibited by a variety of nutritional compounds providing health benefits. The aim of this review is to examine the ability of different dietary polyunsaturated fatty acids (PUFAs) to induce apoptosis, especially in the cancer field. The molecular effects of different PUFAs found in dairy products, meat, fish, vegetable seeds and oils, and known to affect the incidence and progression of cancer and other chronic diseases, will be analyzed. To this aim, our effort will concentrate in critically reviewing the published works concerning the effects of: (a) the n-6 PUFAs γ-linolenic acid, arachidonic acid, and conjugated linoleic acid; (b) the n-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid on the apoptotic process. We will also pay attention to the recent findings regarding the possible role of PUFAs as regulators of the endoplasmic reticulum stress-pathway of apoptosis.

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Acknowledgments

This work was supported in part by grant D1 2008 to G.C. from the Catholic University of Sacred Hearth within its program of promotion and diffusion of scientific research.

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  1. Institute of General Pathology, Catholic University, L. go F. Vito, 1, 00168, Rome, Italy

    Simona Serini, Elisabetta Piccioni & Gabriella Calviello

  2. Department of Environmental Sciences, Tuscia University, Viterbo, Italy

    Nicolò Merendino

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  1. Simona Serini
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Correspondence to Gabriella Calviello.

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Serini, S., Piccioni, E., Merendino, N. et al. Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer. Apoptosis 14, 135–152 (2009). https://doi.org/10.1007/s10495-008-0298-2

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