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Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eye

  • Clinical Investigation
  • Published:
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Abstract

Purpose

To evaluate the preliminary long-term efficacy of diquafosol ophthalmic solution for aqueous-deficient dry eye.

Methods

Fifteen patients with mild-to-moderate aqueous-deficient dry eye were enrolled. After a washout period, the patients were treated with 3 % diquafosol ophthalmic solution for 6 months. We assessed 12 subjective dry eye symptoms, corneal and conjunctival staining with fluorescein, tear film break-up time (BUT), lower tear meniscus height measured with anterior-segment optical coherence tomography, Schirmer’s testing, and adverse reactions at baseline and 1, 3, and 6 months after the start of treatment.

Results

Treatment with diquafosol ophthalmic solution significantly improved dry eye symptoms, corneal staining, BUT, and tear meniscus height at 1 month and maintained the effectiveness for 6 months. Conjunctival staining significantly improved 3 and 6 months after treatment. No significant adverse reactions developed.

Conclusions

Prolonged use of diquafosol ophthalmic solution for 6 months produced significant improvement both subjectively (dry eye symptom score) and objectively (ocular staining score and tear function tests) for aqueous-deficient dry eye.

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Acknowledgments

The authors thank Dr. Geunyoung Yoon and Mr. Kamran Ahmad (University of Rochester Flaum Eye Institute, Ocular Surface Laboratory) for providing the software to analyze the AS-OCT images. This study was supported in part by a Grant-in-Aid No. 22791659 (to Dr. Koh) for Scientific Research from the Japanese Ministry of the Education, Culture, Sports, Science and Technology.

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Authors and Affiliations

  1. Department of Ophthalmology, Osaka University Graduate School of Medicine, Room E7, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Shizuka Koh, Chikako Ikeda, Yoshihiro Takai, Hitoshi Watanabe, Naoyuki Maeda & Kohji Nishida

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  1. Shizuka Koh
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  2. Chikako Ikeda
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  3. Yoshihiro Takai
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Correspondence to Shizuka Koh.

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Koh, S., Ikeda, C., Takai, Y. et al. Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eye. Jpn J Ophthalmol 57, 440–446 (2013). https://doi.org/10.1007/s10384-013-0251-y

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  • DOI: https://doi.org/10.1007/s10384-013-0251-y

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