Zusammenfassung
Nahrungsmittelallergien können zu lebensbedrohlichen Symptomen führen und vermindern die Lebensqualität betroffener Kinder und Jugendlicher. Die Prävalenz der Nahrungsmittelallergie ist zunehmend und unterliegt einer starken regionalen Variabilität. Obwohl eine Großzahl unterschiedlicher Nahrungsmittel verzehrt wird sind nur wenige Nahrungsmittel für eine allergische Reaktion verantwortlich (Milch, Hühnerei, Getreide, Soya, Fisch, Krebsttiere, Nüsse und Erdnüsse). Immunologische Mechanismen einer Nahrungsmittelallergie umfassen IgE-vermittelte (häufig) und nicht-IgE-vermittelte (schwerer zu diagnostizieren) Reaktionen. Die Behandlung basiert auf einer strikten Allergenkarenz. Medikamentöse Notmaßnahmen helfen die Symptomatik zu kontrollieren/limittieren, aber eine kurative Therapie steht zurzeit nicht zur Verfügung.
Summary
Food allergies can result in life-threatening reactions and diminish quality of life. The prevalence of food allergies has increased in several regions throughout the world. A few food allergens cover the majority of food-related reactions (milk, egg, wheat, soy, fish, crustacean, nuts and peanut). Immunological mechanisms range between IgE-mediated (most common) and non-IgE-mediated, the latter of which remaining often a clue in the diagnosis. Treatment of food allergy involves strict avoidance of the trigger food. Medications help to manage symptoms of disease, but currently, there is no cure for food allergy.
Literatur
Boyce JA, Assa’ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126:1–58.
Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638–46.
Kleine-Tebbe J, Ballmer-Weber B, Beyer K, et al. In-vitro-Diagnostik und molekulare Grundlagen von IgE-vermittelten Nahrungsmittelallergien. Allergo J. 2009;18:132–46.
Boyce JA, Assa’ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. J Allergy Clin Immunol. 2010;126:1105–18.
Burks AW, Tang M, Sicherer S, et al. ICON: food allergy. J Allergy Clin Immunol. 2012;129:906–20.
Sackeyfio A, Senthinathan A, Kandaswamy P, Barry PW, Shaw B, Baker M. Diagnosis and assessment of food allergy in children and young people: summary of NICE guidance. BMJ. 2011;342:d747.
Urisu A, Ebisawa M, Mukoyama T, Morikawa A, Kondo N. Japanese guideline for food allergy. Allergol Int. 2011;60:221–36.
Fiocchi A, Schunemann HJ, Brozek J, et al. Diagnosis and Rationale for Action Against Cow’s Milk Allergy (DRACMA): a summary report. J Allergy Clin Immunol. 2010;126:1119–28 e12.
Werfel T. Skin manifestations in food allergy. Allergy 2001;56(Suppl 67):98–101.
Sloan AE, Powers ME. A perspective on popular perceptions of adverse reactions to foods. J Allergy Clin Immunol. 1986;78:127–33.
Altman DR, Chiaramonte LT. Public perception of food allergy. J Allergy Clin Immunol. 1996;97:1247–51.
Eggesbo M, Halvorsen R, Tambs K, Botten G. Prevalence of parentally perceived adverse reactions to food in young children. Pediatr Allergy Immunol. 1999;10:122–32.
Steinke M, Fiocchi A, Kirchlechner V, et al. Perceived food allergy in children in 10 European nations. A randomised telephone survey. Int Arch Allergy Immunol. 2007;143:290–5.
Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy 1990;45:587–96.
Sicherer SH. Clinical aspects of gastrointestinal food allergy in childhood. Pediatrics 2003;111:1609–16.
Sicherer SH, Sampson HA. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol. 2007;120:491–503 (quiz 4–5).
Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of seafood allergy in the United States determined by a random telephone survey. J Allergy Clin Immunol. 2004;114:159–65.
Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics 2009;124:1549–55.
Hadis U, Wahl B, Schulz O, et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 2011;34:237–46.
Leavy O. Immune tolerance: new peacekeepers identified. Nat Rev Immunol. 2010;10:290.
Cochrane S, Beyer K, Clausen M, et al. Factors influencing the incidence and prevalence of food allergy. Allergy 2009;64:1246–55.
Hoffmann-Sommergruber K, Mills EN. Food allergen protein families and their structural characteristics and application in component-resolved diagnosis: new data from the EuroPrevall project. Anal Bioanal Chem. 2009;395:25–35.
Rothenberg ME. Biology and treatment of eosinophilic esophagitis. Gastroenterology 2009;137:1238–49.
Fiocchi A, Nowak-Wegrzyn A. The fascinating world of molecular diagnosis in the management of food allergy: nondum matura est. Curr Opin Allergy Clin Immunol. 2011;11:200–3.
Sanz ML, Blazquez AB, Garcia BE. Microarray of allergenic component-based diagnosis in food allergy. Curr Opin Allergy Clin Immunol. 2011;11:204–9.
Nicolaou N, Custovic A. Molecular diagnosis of peanut and legume allergy. Curr Opin Allergy Clin Immunol. 2011;11:222–8.
Ballmer-Weber BK, Hoffmann-Sommergruber K. Molecular diagnosis of fruit and vegetable allergy. Curr Opin Allergy Clin Immunol. 2011;11:229–35.
Niggemann B. When is an oral food challenge positive? Allergy 2010;65:2–6.
Niggemann B, Beyer K. Pitfalls in double-blind, placebo-controlled oral food challenges. Allergy 2007;62:729–32.
Niggemann B, Beyer K, Erdmann S, et al. Standardisierung von oralen Provokationstests bei Verdacht auf Nahrungsmittelallergie. Allergo J 2011;20:149–60.
Finkelman FD. Peanut allergy and anaphylaxis. Curr Opin Immunol 2010;22:783–8.
Beyer K. A European perspective on immunotherapy for food allergies. J Allergy Clin Immunol. 2012;129:1179–84.
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Szépfalusi, Z. Nahrungsmittelallergien im Kindesalter. Wien Med Wochenschr 162, 525–532 (2012). https://doi.org/10.1007/s10354-012-0157-1
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DOI: https://doi.org/10.1007/s10354-012-0157-1