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Diagnostische Tests für Endometriose

Neue molekularbiologische Untersuchungen

Diagnostic tests for endometriosis

New molecular biological investigations

  • Leitthema
  • Published:
Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Der Goldstandard bei der Diagnosestellung der Endometriose ist auch heute noch die Laparoskopie mit histologischer Sicherung. Ein nichtinvasiver diagnostischer Test mit hoher Sensitivität und Spezifität für diese Erkrankung wäre wünschenswert. Die Bestimmung des Tumormarkers CA 125 für die Diagnose einer Endometriose wird diskutiert. Diese Methode ist jedoch nicht dazu geeignet, eine minimale bis milde Endometriose zu identifizieren und weist zudem eine geringe Sensitivität auf. Andere Kandidaten wie Tumornekrosefaktor-α, Interleukin-6, luteinisierendes Hormon, Leukozytensubtypen, Haptoglobin-β-Kettenisoform E, Thomsen-Friedenreich-Antigene und eosinophile Peroxidase wurden von den verschiedensten Forschergruppen als diagnostische Tests vorgeschlagen. Unsere Arbeitsgruppe empfiehlt die Bestimmung von CCR1-mRNA („cognate chemokin receptor 1“) aus peripheren Blutleukozyten als neuen diagnostischen Test.

Abstract

Laparoscopy with histological confirmation is considered to be the “gold standard” for the diagnosis of endometriosis. New diagnostic tests are necessary to identify endometriosis especially in its early stages. Therefore, a non-invasive test with high sensitivity and specificity would be desirable. Measurement of the tumour marker CA 125 is under discussion for diagnosing endometriosis, however, this marker is not suitable for the detection of patients with minimal or mild forms and only provides very low levels of sensitivity. Other suggested candidates, such as tumour necrosis factor-α, interleukin 6, luteinizing hormone, leukocyte subtypes, haptoglobin beta chain isoform E, Thomsen Friedenreich antigen and eosinophil peroxidase have been proposed by different research groups as diagnostic tools. Our group suggests the determination of cognate chemokine receptor 1 mRNA from peripheral blood leukocytes as a new diagnostic test.

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Authors and Affiliations

  1. Universitätsfrauenklinik, Universität Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 , Lübeck, Deutschland

    S. Dogan, A. Agic, W. Frenzel, D. Finas, K. Diedrich &  D. Hornung

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  1. S. Dogan
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  2. A. Agic
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  3. W. Frenzel
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  4. D. Finas
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  5. K. Diedrich
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  6. D. Hornung
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Correspondence to D. Hornung.

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Dogan, S., Agic, A., Frenzel, W. et al. Diagnostische Tests für Endometriose. Gynäkologische Endokrinologie 4, 128–132 (2006). https://doi.org/10.1007/s10304-006-0151-z

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  • DOI: https://doi.org/10.1007/s10304-006-0151-z

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