Abstract
We report the case of a patient who developed typical cluster headache attacks and was diagnosed as having multiple sclerosis (MS) at the same time. The headache attacks resolved after i.v. treatment with methylprednisolone. MR imaging showed a pontine demyelinating lesion involving the trigeminal nerve root inlet area, on the same side as the pain. The association between cluster headache and MS has been rarely described before. This case suggests that in patients with cluster headache neuroimaging is often useful in order to exclude structural lesions.
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References
Elkbom K (1999) Cluster headache: a clinical and pathophysiological overview. In: Olesen J, Goadsby PJ (eds) Cluster headache and related conditions, Oxford University Press, Oxford, pp 14–22
Headache Classification Subcommittee of the International Headache Society (2004). The International Classification of Headache Disorders — 2nd Edition. Cephalalgia 24(Suppl 1):1–151
Giraud P, Jouanneau E, Borson-Chazot F et al (2002) Cluster-like headache: literature review. J Headache Pain 3:71–78
Favier I, van Vliet JA, Roon KI et al (2007) Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases. Arch Neurol 64:25–31
Leandri M, Cruccu G, Gottlieb A (1999). Cluster headache-like pain in multiple sclerosis. Cephalalgia 19:732–734
Then Berg F, Dose T, Forderreuther S et al (2000). Symptomatischer Clusterkopfschmerz. Ausdruck eines MS-Schubes mit kernspintomographischem N achweis einer pontomedullären Läsion des ipsilateralen Trigeminuskerngiebetes. Nervenarzt 71:1000–1002
Polman CH, Reingold SC, Edan G et al (2005) Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol 58:840–846
Almarcegui C, Lorente S, Romero MF et al (1999) Blink reflex in trigeminal hypoesthesia caused by a pontine demyelinating lesion. J Neurol 246:140–141
Love S, Gradidge T, Coakham HB (2001) Trigeminal neuralgia due to multiple sclerosis: ultrastructural findings in trigeminale rhizotomy specimens. Neuropathol Appl Neurobiol 27:238–244
Matharu MS, Goadsby PJ (2002) Persistence of attacks of cluster headache after trigeminal nerve root section. Brain 125:976–84
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Gentile, S., Ferrero, M., Vaula, G. et al. Cluster headache attacks and multiple sclerosis. J Headache Pain 8, 245–247 (2007). https://doi.org/10.1007/s10194-007-0405-8
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DOI: https://doi.org/10.1007/s10194-007-0405-8