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Relationship between hospital volume and hemorrhagic complication after percutaneous renal biopsy: results from the Japanese diagnosis procedure combination database

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Abstract

Background

Although hemorrhagic complications are major complications of percutaneous renal biopsy (PRB), the relationship between procedure volume and morbidity remains unclear for PRB. The present study investigated the impact of hospital volume on the occurrence of hemorrhagic complications after PRB.

Methods

Using large claims-based data in the diagnosis procedure combination database in Japan, we identified inpatients with renal disorders who underwent PRB within 4 days after admission during July to December 2007 to 2010. We assessed patient age, sex, clinical syndromes, hemorrhagic complications and diagnoses, and annual hospital volume of PRB divided into quintiles. Multivariate logistic regression analyses fitted with a generalized estimation equation were performed accounting for within-hospital clustering.

Results

A total of 15,191 patients were identified from 942 hospitals. The overall proportion of hemorrhagic complications was 2.1 %, including diagnoses of hemorrhagic events (1.6 %), red blood cell transfusion (0.5 %), and requiring angiography or endovascular procedure (0.1 %). In-hospital deaths attributable to the complications occurred in 0.06 % of the patients. Patients with rapidly progressive nephritic syndrome (odds ratio 3.41, 95 % confidence interval 2.22–5.25) had significantly higher incidence than those with chronic nephritic syndrome. No significant association was observed between hospital volume and hemorrhagic complications, with odds ratios for the low-intermediate, intermediate, intermediate-high, and high-volume groups relative to the low-volume group of 0.74 (0.43–1.26), 1.19 (0.74–1.92), 1.16 (0.67–2.00), and 1.35 (0.78–2.34), respectively.

Conclusions

No significant relationship was observed between hemorrhagic complication incidence and hospital volume regarding PRB.

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Acknowledgments

This work was accepted as a poster presentation at Kidney Week 2013, Annual Meeting of the American Society of Nephrology, November 5–10, 2013, Atlanta, GA. This study was supported by Grants-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare, Japan (H22-Policy-031 and, in part, H22-Policy-033); by a Grant-in-Aid for Scientific Research B (No. 22390131) from the Ministry of Education, Culture, Sports, Science and Technology, Japan; and by the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST program) from the Council for Science and Technology Policy, Japan (No. 0301002001001).

Conflict of interest

All the authors have declared no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Health and Social Behavior, School of Public Health, The University of Tokyo, Tokyo, Japan

    Hiroyuki Yamamoto & Hideki Hashimoto

  2. Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Mitsuhiro Nakamura

  3. Department of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, Tokyo, Japan

    Hiromasa Horiguchi

  4. Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Hideo Yasunaga

Authors
  1. Hiroyuki Yamamoto
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  2. Hideki Hashimoto
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  3. Mitsuhiro Nakamura
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  4. Hiromasa Horiguchi
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  5. Hideo Yasunaga
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Corresponding author

Correspondence to Hideo Yasunaga.

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Yamamoto, H., Hashimoto, H., Nakamura, M. et al. Relationship between hospital volume and hemorrhagic complication after percutaneous renal biopsy: results from the Japanese diagnosis procedure combination database. Clin Exp Nephrol 19, 271–277 (2015). https://doi.org/10.1007/s10157-014-0986-x

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  • DOI: https://doi.org/10.1007/s10157-014-0986-x

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