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Evolution of the techniques of radiation therapy in the management of lymphoma

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Abstract

Radiation techniques for the treatment of Hodgkin’s disease have evolved dramatically in the past century. Shortly after the discovery of X-rays, the lymphomas in general, and Hodgkin’s disease in particular, were noted to be radiosensitive. However, equipment limitations restricted the ability to administer sufficient doses to adequate depth to ensure long-term control. This situation improved sequentially with the development of the Coolidge tube, 60Co machine, and medical linear accelerators. With megavoltage radiation it was possible to demonstrate cures of stage I–II disease with high-dose extended-field irradiation. When combined modality therapy programs were introduced, this permitted restriction of radiation fields and doses in order to decrease toxicity. Innovative advanced technologies such as PET simulation, 3-D treatment planning, intensity-modulated radiotherapy, active breathing control, and proton therapy have further improved the outcomes for patients treated with irradiation.

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References

  1. Hodgkin T (1832) On some morbid appearances of the absorbent glands and spleen. Med-Chir Trans 17:68–114

    PubMed  CAS  Google Scholar 

  2. Wilks S (1865) Cases of enlargement of the lymphatic glands and spleen (or, Hodgkin’s disease), with remarks. Guy’s Hosp Rep 11:56–67

    Google Scholar 

  3. Reed D (1902) On the pathological changes in Hodgkin’s disease with especial reference to its relation to tuberculosis. John Hopkins Rep 10:133–196

    Google Scholar 

  4. Pusey WA (1902) Cases of sarcoma and of Hodgkin’s disease treated by exposure to X-rays—a preliminary report. JAMA 38:166–169

    Article  Google Scholar 

  5. Senn N (1903) The therapeutical value of the Roentgen ray in the treatment of pseudoleucaemia. N Y Med J 77:664–668

    Google Scholar 

  6. Desjardins A (1923) The radiation treatment of Hodgkin’s disease with particular reference to mediastinal involvement. Radiology 1:161–171

    Google Scholar 

  7. Gilbert R, Babaïantz L. Notre méthode de roentgenthérapie de la lymphogranulomatose (Hodgkin): résultats éloignés. Acta Radiol. 1931;12

  8. Peters MV. A study of survivals in Hodgkin’s disease treated radiologically. Am J Roentgenol. 1950;63(Radiation Therapy):299–311

    Google Scholar 

  9. Kaplan H (1948) Comparative susceptibility of the lymphoid tissues of strain C57 black mice to the induction of lymphoid tumors by irradiation. J Natl Cancer Inst 8:191–197

    PubMed  CAS  Google Scholar 

  10. Brown FA, Kaplan HS (1957) Hodgkin’s disease: a revised clinical classification and an approach to the treatment of its localized form. Stanford Med Bull 15(3):183–190

    PubMed  CAS  Google Scholar 

  11. Kaplan HS (1962) The radical radiotherapy of regionally localized Hodgkin’s disease. Radiology 78:553–561

    PubMed  CAS  Google Scholar 

  12. Kaplan HS, Rosenberg S. Extended-field radical radiotherapy in advanced Hodgkin’s disease: short-term results of 2 randomized clinical trials. Cancer Res. 1966;26:1268–1276

    Google Scholar 

  13. Rosenberg SA, Kaplan HS (1985) The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin’s disease: 1962–1984. Int J Radiat Oncol Biol Phys 11(1):5–22

    Article  PubMed  CAS  Google Scholar 

  14. Kaplan HS. Hodgkin’s disease. Cambridge, Mass: Harvard University Press; 1972

  15. Brown AP, Urie MM, Barest G et al (1991) Three-dimensional photon treatment planning for Hodgkin’s disease. Int J Radiat Oncol Biol Phys 21(1):205–215

    Article  PubMed  CAS  Google Scholar 

  16. Fox AM, Dosoretz AP, Mauch PM et al (2012) Predictive factors for radiation pneumonitis in Hodgkin lymphoma patients receiving combined-modality therapy. Int J Radiat Oncol Biol Phys 83(1):277–283

    Article  PubMed  Google Scholar 

  17. Cella L, Conson M, Caterino M et al (2012) Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin’s lymphoma. Int J Radiat Oncol Biol Phys 82(5):1802–1808

    Article  PubMed  Google Scholar 

  18. Hoppe R, Loo BW, Jr. Lymphoma: overview. In: Mundt A, Roeske J, eds. Intensity modulated radiation therapy—a clinical perspective. Toronto: B.C. Decker. 2005:535–546

  19. Goodman KA, Toner S, Hunt M et al (2005) Intensity-modulated radiotherapy for lymphoma involving the mediastinum. Int J Radiat Oncol Biol Phys 62(1):198–206

    Article  PubMed  Google Scholar 

  20. Weber DC, Peguret N, Dipasquale G et al (2009) Involved-node and involved-field volumetric modulated arc vs. fixed beam intensity-modulated radiotherapy for female patients with early-stage supra-diaphragmatic Hodgkin lymphoma: a comparative planning study. Int J Radiat Oncol Biol Phys 75(5):1578–1586

    Article  PubMed  Google Scholar 

  21. Girinsky T, Pichenot C, Beaudre A et al (2006) Is intensity-modulated radiotherapy better than conventional radiation treatment and three-dimensional conformal radiotherapy for mediastinal masses in patients with Hodgkin’s disease, and is there a role for beam orientation optimization and dose constraints assigned to virtual volumes? Int J Radiat Oncol Biol Phys 64(1):218–226

    Article  PubMed  Google Scholar 

  22. Weber DC, Johanson S, Peguret N et al (2011) Predicted risk of radiation-induced cancers after involved field and involved node radiotherapy with or without intensity modulation for early-stage Hodgkin lymphoma in female patients. Int J Radiat Oncol Biol Phys 81(2):490–497

    Article  PubMed  Google Scholar 

  23. Hoppe BS, Flampouri S, Su Z et al (2012) Consolidative involved-node proton therapy for Stage IA-IIIB mediastinal Hodgkin lymphoma: preliminary dosimetric outcomes from a Phase II study. Int J Radiat Oncol Biol Phys 83(1):260–267

    Article  PubMed  Google Scholar 

  24. Hoppe BS, Flampouri S, Su Z et al (2012) Effective dose reduction to cardiac structures using protons compared with 3DCRT and IMRT in mediastinal Hodgkin lymphoma. Int J Radiat Oncol Biol Phys 84(2):449–455

    Article  PubMed  Google Scholar 

  25. Korreman SS, Juhler-Nottrup T, Boyer AL (2008) Respiratory gated beam delivery cannot facilitate margin reduction, unless combined with respiratory correlated image guidance. Radiother Oncol 86(1):61–68

    Article  PubMed  Google Scholar 

  26. Stromberg JS, Sharpe MB, Kim LH et al (2000) Active breathing control (ABC) for Hodgkin’s disease: reduction in normal tissue irradiation with deep inspiration and implications for treatment. Int J Radiat Oncol Biol Phys 48(3):797–806

    Article  PubMed  CAS  Google Scholar 

  27. Paumier A, Ghalibafian M, Gilmore J et al (2012) Dosimetric benefits of intensity-modulated radiotherapy combined with the deep-inspiration breath-hold technique in patients with mediastinal Hodgkin’s lymphoma. Int J Radiat Oncol Biol Phys 82(4):1522–1527

    Article  PubMed  Google Scholar 

  28. Ferme C, Eghbali H, Meerwaldt JH et al (2007) Chemotherapy plus involved-field radiation in early-stage Hodgkin’s disease. N Engl J Med 357(19):1916–1927

    Article  PubMed  CAS  Google Scholar 

  29. Engert A, Schiller P, Josting A et al (2003) Involved-field radiotherapy is equally effective and less toxic compared with extended-field radiotherapy after four cycles of chemotherapy in patients with early-stage unfavorable Hodgkin’s lymphoma: results of the HD8 trial of the German Hodgkin’s Lymphoma Study Group. J Clin Oncol 21(19):3601–3608

    Article  PubMed  Google Scholar 

  30. Bonadonna G, Bonfante V, Viviani S et al (2004) ABVD plus subtotal nodal versus involved-field radiotherapy in early-stage Hodgkin’s disease: long-term results. J Clin Oncol 22(14):2835–2841

    Article  PubMed  Google Scholar 

  31. Girinsky T, van der Maazen R, Specht L et al (2006) Involved-node radiotherapy (INRT) in patients with early Hodgkin lymphoma: concepts and guidelines. Radiother Oncol 79(3):270–277

    Article  PubMed  Google Scholar 

  32. National Comprehensive Cancer Network. Clinical practice guidelines in oncology (NCCN Guidelines(r)) for Hodgkin’s lymphomas. 2013:1

  33. Hutchings M, Loft A, Hansen M et al (2006) Position emission tomography with or without computed tomography in the primary staging of Hodgkin’s lymphoma. Haematologica 91(4):482–489

    PubMed  Google Scholar 

  34. Girinsky T, Ghalibafian M, Bonniaud G et al (2007) Is FDG–PET scan in patients with early stage Hodgkin lymphoma of any value in the implementation of the involved-node radiotherapy concept and dose painting? Radiother Oncol 85(2):178–186

    Article  PubMed  Google Scholar 

  35. Pommier P, Dussart S, Girinsky T et al (2011) Impact of 18F-fluoro-2-deoxyglucose positron emission tomography on treatment strategy and radiotherapy planning for stage I-II Hodgkin disease: a prospective multicenter study. Int J Radiat Oncol Biol Phys 79(3):823–828

    Article  PubMed  Google Scholar 

  36. Terezakis SA, Hunt MA, Kowalski A et al (2011) [18F]FDG-positron emission tomography coregistration with computed tomography scans for radiation treatment planning of lymphoma and hematologic malignancies. Int J Radiat Oncol Biol Phys 81(3):615–622

    Article  PubMed  Google Scholar 

  37. Engert A, Plutschow A, Eich HT et al (2010) Reduced treatment intensity in patients with early-stage Hodgkin’s lymphoma. N Engl J Med 363(7):640–652

    Article  PubMed  CAS  Google Scholar 

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The author declares that he has no conflict of interest.

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Authors and Affiliations

  1. Department of Radiation Oncology, Stanford University, Stanford, CA, USA

    Richard T. Hoppe

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  1. Richard T. Hoppe
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Correspondence to Richard T. Hoppe.

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Hoppe, R.T. Evolution of the techniques of radiation therapy in the management of lymphoma. Int J Clin Oncol 18, 359–363 (2013). https://doi.org/10.1007/s10147-013-0556-3

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  • DOI: https://doi.org/10.1007/s10147-013-0556-3

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