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A scientific paradigm for targeted nanophotothermolysis; the potential for nanosurgery of cancer

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Abstract

The application of gold nanoparticles (AuNPs) in nanophotothermolysis as a great photosensitizer is expanding, and this subject is a challenging area for cancer therapy. Recent technological advances in nanoscale manufacturing and synthesis promise the development of highly beneficial and innovative methods for the targeting of cancer. However, there is an obstacle to conducting effective laser-based nanosurgery because AuNPs are activated by visible or near infrared wavelengths, and the penetration of a laser beam inside the body is limited by some absorbents, such as melanin, water, and blood molecules. Considering everything stated above, we have suggested the application of a folate-conjugated AuNP as an effective agent for targeted nanophotothermolysis and the application of an optical fiber to transport the laser light from the source to the target tissue inside the body. Thus, a new method of nanosurgery in which a surgeon is able to perform surgery at the cellular or even at the subcellular level may be possible.

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Acknowledgments

We greatly appreciate the ENT-Head and Neck Research Center at Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), for supporting our project.

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Authors and Affiliations

  1. Clinical Nanomedicine Laboratory, ENT-Head and Neck Research Center, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

    Ali Shakeri-Zadeh, Seyed Kamran Kamrava, Mohammad Farhadi & Shayan Maleki

  2. Medical Physics Department, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Ali Shakeri-Zadeh & Zahra Hajikarimi

  3. Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, P.O. Box 48175-861, Sari, Iran

    Amirhossein Ahmadi

Authors
  1. Ali Shakeri-Zadeh
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  2. Seyed Kamran Kamrava
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  3. Mohammad Farhadi
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  4. Zahra Hajikarimi
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  5. Shayan Maleki
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  6. Amirhossein Ahmadi
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Corresponding authors

Correspondence to Seyed Kamran Kamrava or Amirhossein Ahmadi.

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Shakeri-Zadeh, A., Kamrava, S.K., Farhadi, M. et al. A scientific paradigm for targeted nanophotothermolysis; the potential for nanosurgery of cancer. Lasers Med Sci 29, 847–853 (2014). https://doi.org/10.1007/s10103-013-1399-x

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  • DOI: https://doi.org/10.1007/s10103-013-1399-x

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