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In vivo photoacoustic imaging of blood vessels with a pulsed laser diode

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Abstract

Photoacoustic imaging is a hybrid imaging modality that is based on the detection of acoustic waves generated by absorption of pulsed light by tissue chromophores such as hemoglobin in blood. For this technique, usually large and costly Q-switched Nd:YAG lasers are used. These lasers provide a pulse energy of at least several milliJoules. In search of alternative light sources, we investigated the use of a small and compact pulsed laser diode to image blood vessels. We proved that a pulsed laser diode can be applied for imaging blood vessels in vivo.

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Acknowledgements

This work was partly funded by the Netherlands Foundation of Fundamental Research on Matter FOM (grant 00PMT22) and the Institute for BioMedical Technology (BMTI) of the University of Twente.

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Authors and Affiliations

  1. Biophysical Engineering, Institute for BioMedical Technology, Faculty of Science and Technology, University of Twente, P.O. Box 217, Enschede, 7500 AE, The Netherlands

    Roy G. M. Kolkman, Wiendelt Steenbergen & Ton G. van Leeuwen

  2. Laser Center, Academic Medical Center, University of Amsterdam, P.O. Box 22700, Amsterdam, 1100 DE, The Netherlands

    Ton G. van Leeuwen

Authors
  1. Roy G. M. Kolkman
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  2. Wiendelt Steenbergen
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  3. Ton G. van Leeuwen
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Correspondence to Roy G. M. Kolkman.

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Kolkman, R.G.M., Steenbergen, W. & van Leeuwen, T.G. In vivo photoacoustic imaging of blood vessels with a pulsed laser diode. Lasers Med Sci 21, 134–139 (2006). https://doi.org/10.1007/s10103-006-0384-z

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  • DOI: https://doi.org/10.1007/s10103-006-0384-z

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