Abstract
The therapeutic benefits of interferon-beta are limited, as some patients with multiple sclerosis (MS) do not respond to therapy. Based on their biological characteristics, non-responsive patients can be divided into three subgroups: genetic, pharmacological and pathogenetic non-responders. In order to tailor the best treatment in both newly diagnosed MS patients and those already receiving treatment, the neurologist must carefully consider the risk of treating non-responders.
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References
Rio J, Nos C, Tintoré M et al (2006) Defining the response to interferon-beta in relapsing-remitting multiple sclerosis patients. Ann Neurol 59:344–352
Gilli F, Valentino P, Sala A et al (2007) Correlation between gene expression of interferon alpha/beta receptor and inducibility of four interferon stimulated genes in peripheral blood mononuclear cells from multiple sclerosis patients. Mult Scler 13[Suppl 2]:S65,P227
Mathurin P, Xiong S, Kharbanda KK et al (2002) IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 282:G981–G990
Karussis D, Biermann LD, Bohlega S et al; the International Working Group for Treatment Optimization in MS (2006) A recommended treatment algorithm in relapsing multiple sclerosis: report of an international consensus meeting. Eur J Neurol 13:61–71
Vallittu AM, Halminen M, Peltoniemi J et al; Finnish Beta-Interferon Study Group (2002) Neutralizing antibodies reduce MxA protein induction in interferon beta-1a-treated MS patients. Neurology 58:1786–1790
Gilli F, Bertolotto A, Sala A et al (2004) Neutralizing antibodies against IFN-beta in multiple sclerosis: antagonization of IFN-beta mediated suppression of MMPs. Brain 127:259–268
Gilli F, Bertolotto A, Sala A et al (2005) Biological responsiveness to first injections of interferon-beta in patients with multiple sclerosis. J Neuroimmunol 158:195–203
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Bertolotto, A., Gilli, F. Interferon-beta responders and non-responders. A biological approach. Neurol Sci 29 (Suppl 2), 216–217 (2008). https://doi.org/10.1007/s10072-008-0941-2
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DOI: https://doi.org/10.1007/s10072-008-0941-2