Skip to main content
SpringerLink
Log in

Renal Metanephric Adenoma With Previously Unreported Cytogenetic Abnormalities: Case Report and Review of the Literature

  • Published:
Pediatric and Developmental Pathology

Abstract

We report a case of a renal metanephric adenoma in a 10-year-old boy, in which cytogenetic analysis showed a balanced translocation, t(9;15)(p24;q24) and a balanced paracentric inversion of chromosome 12, inv(12)(q13q15). Immunohistochemically, the tumor showed diffuse reactivity for cytokeratin AE1/AE3, CAM5.2, CD57, and WT1; patchy reactivity for CD56; and focal reactivity for cytokeratin 7, epithelial membrane antigen, and CD10. Tumor cells were entirely nonreactive for α-methyl acyl coenzyme A racemase. Published cytogenetic data for metanephric adenomas are limited, and this is the first report of these cytogenetic abnormalities. The involvement of the chromosome region 9p24 is particularly interesting because of the recent identification of a tumor suppressor gene, KANK (kidney ankyrin repeat-containing protein), at this locus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

Similar content being viewed by others

References

  1. MB Amin MB Amin P Tamboli et al. (2002) ArticleTitlePrognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases Am J Surg Pathol 26 281–291 Occurrence Handle10.1097/00000478-200203000-00001 Occurrence Handle11859199

    Article  PubMed  Google Scholar 

  2. F Mitelman (Eds) (1995) An International System for Human Cytogenetic Nomenclature S. Karger Basel

    Google Scholar 

  3. CJ Davis SuffixJr JH Barton IA Sesterhenn et al. (1995) ArticleTitleMetanephric adenoma. Clinicopathological study of fifty patients Am J Surg Pathol 19 1101–1114 Occurrence Handle7573669

    PubMed  Google Scholar 

  4. P Argani JB Beckwith (2000) ArticleTitleMetanephric stromal tumor: report of 31 cases of a distinctive pediatric renal neoplasm Am J Surg Pathol 24 917–926 Occurrence Handle10.1097/00000478-200007000-00003 Occurrence Handle1:STN:280:DC%2BD3czlt1Kqug%3D%3D Occurrence Handle10895814

    Article  CAS  PubMed  Google Scholar 

  5. MR Arroyo DM Green EJ Perlman et al. (2001) ArticleTitleThe spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center Am J Surg Pathol 25 433–444 Occurrence Handle10.1097/00000478-200104000-00002 Occurrence Handle1:STN:280:DC%2BD3M3hs12qug%3D%3D Occurrence Handle11257617

    Article  CAS  PubMed  Google Scholar 

  6. AG Anastasiadis T Ebert CD Gerharz et al. (2001) ArticleTitleSimultaneous diagnosis of a metanephric adenoma and a clear cell carcinoma of the contralateral kidney Eur Urol 39 236–239 Occurrence Handle10.1159/000052442 Occurrence Handle1:STN:280:DC%2BD3MzjvVClsw%3D%3D Occurrence Handle11223686

    Article  CAS  PubMed  Google Scholar 

  7. MR Pins EC Jones EV Martul et al. (1999) ArticleTitleMetanephric adenoma-like tumors of the kidney: report of 3 malignancies with emphasis on discriminating features Arch Pathol Lab Med 123 415–420 Occurrence Handle1:STN:280:DyaK1M3kvFGkuw%3D%3D Occurrence Handle10235500

    CAS  PubMed  Google Scholar 

  8. EC Jones M Pins GR Dickersin et al. (1995) ArticleTitleMetanephric adenoma of the kidney. A clinicopathological, immunohistochemical, flow cytometric, cytogenetic, and electron microscopic study of seven cases Am J Surg Pathol 19 615–626 Occurrence Handle1:STN:280:DyaK2M3nsVOrtg%3D%3D Occurrence Handle7755148 Occurrence Handle10.1097/00000478-199506000-00001

    Article  CAS  PubMed  Google Scholar 

  9. TE Muir JC Cheville DJ Lager (2001) ArticleTitleMetanephric adenoma, nephrogenic rests, and Wilms’ tumor: a histologic and immunophenotypic comparison Am J Surg Pathol 25 1290–1296 Occurrence Handle10.1097/00000478-200110000-00010 Occurrence Handle1:STN:280:DC%2BD3MnjsFantQ%3D%3D Occurrence Handle11688464

    Article  CAS  PubMed  Google Scholar 

  10. DM Loeb S Sukumar (2002) ArticleTitleThe role of WT1 in oncogenesis: tumor suppressor or oncogene? Int J Hematol 76 117–126 Occurrence Handle1:CAS:528:DC%2BD38XntlWjsLc%3D Occurrence Handle12215009 Occurrence Handle10.1007/BF02982573

    Article  CAS  PubMed  Google Scholar 

  11. G Kovacs L Fuzesi A Emanual et al. (1991) ArticleTitleCytogenetics of papillary renal cell tumors Genes Chromosomes Cancer 3 249–255 Occurrence Handle1:STN:280:DyaK38%2FmvV2isQ%3D%3D Occurrence Handle1958590

    CAS  PubMed  Google Scholar 

  12. JA Brown TJ Sebo JW Segura (1996) ArticleTitleMetaphase analysis of metanephric adenoma reveals chromosome Y loss with chromosome 7 and 17 gain Urology 48 473–475 Occurrence Handle10.1016/S0090-4295(96)00203-8 Occurrence Handle1:STN:280:DyaK28zpslKisQ%3D%3D Occurrence Handle8804507

    Article  CAS  PubMed  Google Scholar 

  13. JA Brown KL Anderl TJ Borell et al. (1997) ArticleTitleSimultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma J Urol 158 370–374 Occurrence Handle10.1097/00005392-199708000-00014 Occurrence Handle1:STN:280:DyaK2szmslKjsA%3D%3D Occurrence Handle9224305

    Article  CAS  PubMed  Google Scholar 

  14. M Brunelli JN Eble S Zhang et al. (2003) ArticleTitleMetanephric adenoma lacks the gains of chromosomes 7 and 17 and loss of Y that are typical of papillary renal cell carcinoma and papillary adenoma Mod Pathol 16 1060–1063 Occurrence Handle10.1097/01.MP.0000090923.50509.55 Occurrence Handle14559991

    Article  PubMed  Google Scholar 

  15. R Drut RM Drut C Ortolani (2001) ArticleTitleMetastatic metanephric adenoma with foci of papillary carcinoma in a child: a combined histologic, immunohistochemical, and FISH study Int J Surg Pathol 9 241–247 Occurrence Handle1:STN:280:DC%2BD3Mrjs1CltA%3D%3D Occurrence Handle11584324

    CAS  PubMed  Google Scholar 

  16. O Hes R Curik V Malatkova et al. (2003) ArticleTitleMetanephric adenoma and papillary carcinoma with sarcomatoid dedifferentiation of kidney A case report. Pathol Res Pract 199 629–632

    Google Scholar 

  17. M Takahashi XJ Yang J Sugimura et al. (2003) ArticleTitleMolecular subclassification of kidney tumors and the discovery of new diagnostic markers Oncogene 22 6810–6818 Occurrence Handle10.1038/sj.onc.1206869 Occurrence Handle1:CAS:528:DC%2BD3sXotVWntr8%3D Occurrence Handle14555994

    Article  CAS  PubMed  Google Scholar 

  18. MS Tretiakova S Sahoo M Takahashi et al. (2004) ArticleTitleExpression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma Am J Surg Pathol 28 69–76 Occurrence Handle14707866

    PubMed  Google Scholar 

  19. M Stumm A Koch PF Wieacker et al. (1999) ArticleTitlePartial monosomy 2p as the single chromosomal anomaly in a case of renal metanephric adenoma Cancer Genet Cytogenet 115 82–85 Occurrence Handle10.1016/S0165-4608(99)00086-2 Occurrence Handle1:STN:280:DC%2BD3c%2FjtVGntA%3D%3D Occurrence Handle10565308

    Article  CAS  PubMed  Google Scholar 

  20. T Pesti F Sukosd EC Jones et al. (2001) ArticleTitleMapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping Hum Pathol 32 101–104 Occurrence Handle10.1053/hupa.2001.21132 Occurrence Handle1:CAS:528:DC%2BD3MXjslKmtbw%3D Occurrence Handle11172302

    Article  CAS  PubMed  Google Scholar 

  21. S Sarkar BC Roy N Hatano et al. (2002) ArticleTitleA novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma J Biol Chem 277 36585–36591 Occurrence Handle10.1074/jbc.M204244200 Occurrence Handle1:CAS:528:DC%2BD38XnsVCisr0%3D Occurrence Handle12133830

    Article  CAS  PubMed  Google Scholar 

  22. T Nagase N Seki K Ishikawa et al. (1996) ArticleTitlePrediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 DNA Res 3 17–24 Occurrence Handle1:CAS:528:DyaK28XjvVOlu7Y%3D Occurrence Handle8724849

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We thank the technical staff at Veripath Laboratories (Immunohistochemistry) of the University of Texas Southwestern Medical Center for excellent immunohistochemical work.

Author information

Authors and Affiliations

  1. Department of Pathology, Children’s Medical Center of Dallas, 1935 Motor Street, Dallas, TX, 75235, USA

    Dinesh Rakheja & Linda R. Margraf

  2. Department of Pediatrics, Children’s Medical Center of Dallas, 1935 Motor Street, Dallas, TX, 75235, USA

    Gail E. Tomlinson

  3. Department of Urology, Children’s Medical Center of Dallas, 1935 Motor Street, Dallas, TX, 75235, USA

    David H. Ewalt

  4. University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA

    Dinesh Rakheja, Gail E. Tomlinson, David H. Ewalt & Linda R. Margraf

  5. Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA

    Fangru Lian & Roger A. Schultz

Authors
  1. Dinesh Rakheja
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fangru Lian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gail E. Tomlinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. David H. Ewalt
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Roger A. Schultz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Linda R. Margraf
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dinesh Rakheja.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rakheja, D., Lian, F., Tomlinson, G.E. et al. Renal Metanephric Adenoma With Previously Unreported Cytogenetic Abnormalities: Case Report and Review of the Literature. Pediatr Dev Pathol 8, 218–223 (2005). https://doi.org/10.1007/s10024-004-7081-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10024-004-7081-3

Keywords

Search

Navigation