Abstract
An 18-year-old girl presented with a history of visual disturbance without headache, nausea, or vomiting in May 2010. In July 2010, the patient visited our hospital because of visual disturbance. Head magnetic resonance images revealed hydrocephalus caused by a ring-enhancing mass lesion located in the vermis. Total tumor removal was performed. Histological findings revealed that honeycomb cells resembling oligodendrocytes accounted for most parts of the tumor. Rosenthal fibers and hyaline droplets were seen in a small portion. The tumor cells were immunoreactive for GFAP and Olig2, but none of the tumor cells were immunoreactive for Symaptophysin, EMA, or IDH 1. according to these findings, the tumor was diagnosed as pilocytic astrocytoma with an abundant oligodendroglioma-like component. Pilocytic astrocytoma is known to be associated with an oligodendroglioma-like component; however, the differential diagnosis for oligodendroglioma may be difficult when an oligodendroglioma-like component occupies most of the tumor.
Similar content being viewed by others
References
Khafaga Y, Hassounah M, Kandil A, Kanaan I, Allam A, El Husseiny G, Kofide A, Belal A, Al Shabanah M, Schultz H, Jenkin D (2003) Optic gliomas: a retrospective analysis of 50 cases. Int J Radiat Oncol Biol Phys 56:807–812
Scheithauer BW, Hawkins C, Tihan T, VandenBerg SR, Burger PC (2007) Pilocytic astrocytoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) World Health Organization Classification of tumour of the central nervous system. International Agency for Research on Cancer (IARC) Press, Lyon, pp 14–21
Tanaka Y, Sasaki A, Ishiuchi S, Nakazato Y (2008) Diversity of glial cell components in pilocytic astrocytoma. Neuropathology 28:399–407
Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A (2008) Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol 116:597–602
Capper D, Reuss D, Schittenhelm J, Hartmann C, Bremer J, Sahm F, Harter PN, Jeibmann A, von Deimling A (2011) Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology. Acta Neuropathol 121:241–252
Baysefer A, Duz B, Erdodan E, Deveci MS (2004) Pediatric cerebellar cystic oligodendroglioma: case report and literature review. Turk J Pediat 46:95–97
Bhatoe HS, Deshpande GU (1999) Childhood cerebellar vermian oligodendroglioma. Neurol India 47:341–342
Gittens WO, Huestis WS, Sangalang VE (1980) Oligodendroglioma of the cerebellum. Surg Neurol 13:237–240
Holliday FP, Fruin AH (1980) Cerebellar oligodendroglioma in a child. Neurosurgery 6:552–554
Packer RJ, Sutton LN, Rorke LB, Zimmerman RA, Littman P, Bruce DA, Schut L (1985) Oligodendroglioma of the posterior fossa in childhood. Cancer 56:195–199
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Utsuki, S., Oka, H., Kijima, C. et al. Pilocytic astrocytoma with abundant oligodendroglioma-like component. Brain Tumor Pathol 29, 103–106 (2012). https://doi.org/10.1007/s10014-011-0074-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10014-011-0074-9