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Periodontal treatment decreases plasma oxidized LDL level and oxidative stress

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Abstract

Periodontitis induces excessive production of reactive oxygen species in periodontal lesions. This may impair circulating pro-oxidant/anti-oxidant balance and induce the oxidation of low-density lipoprotein (LDL) in blood. The purpose of this study was to monitor circulating oxidized LDL and oxidative stress in subjects with chronic periodontitis following non-surgical periodontal treatment. Plasma levels of oxidized LDL and oxidative stress in 22 otherwise healthy non-smokers with chronic periodontitis (mean age 44.0 years) were measured at baseline and at 1 and 2 months after non-surgical periodontal treatment. At baseline, chronic periodontitis patients had higher plasma levels of oxidized LDL and oxidative stress than healthy subjects (p < 0.001). Periodontal treatment was associated with a significant reduction in plasma levels of oxidized LDL (oxLDL)(p < 0.001) and oxidative stress (p < 0.001). At 2 months after periodontal treatment, the degree of change in the oxLDL was positively correlated with that in the oxidative stress (r = 0.593, p = 0.004). These observations indicate that periodontitis patients showed higher levels of circulating oxLDL and oxidative stress than healthy subjects. In addition, improved oral hygiene and non-surgical periodontal treatment were effective in decreasing oxLDL, which was positively associated with a reduction in circulating oxidative stress.

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References

  1. Page RC, Engel LD, Narayanan AS, Clagett JA (1978) Chronic inflammatory gingival and periodontal disease. JAMA 11:545–550

    Article  Google Scholar 

  2. Humphrey LL, Fu R, Buckley DI, Freeman M, Helfand M (2008) Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med 23:2079–2086

    Article  PubMed  Google Scholar 

  3. Tonetti MS (2009) Periodontitis and risk for atherosclerosis: an update on intervention trials. J Clin Periodontol 36:15–19

    Article  PubMed  Google Scholar 

  4. Davé S, Van Dyke T (2008) The link between periodontal disease and cardiovascular disease is probably inflammation. Oral Dis 14:95–101

    Article  PubMed  Google Scholar 

  5. Nakajima T, Honda T, Domon H et al (2010) Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. J Periodont Res 45:116–122

    Article  PubMed  Google Scholar 

  6. Chapple IL (1997) Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol 24:287–296

    Article  PubMed  Google Scholar 

  7. Guentsch A, Preshaw PM, Bremer-Streck S, Klinger G, Glockmann E, Sigusch BW (2008) Lipid peroxidation and antioxidant activity in saliva of periodontitis patients: effect of smoking and periodontal treatment. Clin Oral Investig 12:345–352

    Article  PubMed  Google Scholar 

  8. Su H, Gornitsky M, Velly AM, Yu H, Benarroch M, Schipper HM (2009) Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease. Free Radic Biol Med 46:914–921

    Article  PubMed  Google Scholar 

  9. Takane M, Sugano N, Iwasaki H, Iwano Y, Shimizu N, Ito K (2002) New biomarker evidence of oxidative DNA damage in whole saliva from clinically healthy and periodontally diseased individuals. J Periodontol 73:551–554

    Article  PubMed  Google Scholar 

  10. Akalın FA, Baltacıoğlu E, Alver A, Karabulut E (2007) Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol 34:558–565

    Article  PubMed  Google Scholar 

  11. Baltacioğlu E, Akalin FA, Alver A, Değer O, Karabulut E (2008) Protein carbonyl levels in serum and gingival crevicular fluid in patients with chronic periodontitis. Arch Oral Biol 53:716–722

    Article  PubMed  Google Scholar 

  12. Monteiro AM, Jardini MA, Alves S et al (2009) Cardiovascular disease parameters in periodontitis. J Periodontol 80:378–388

    Article  PubMed  Google Scholar 

  13. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL (1989) Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Eng J Med 320:915–924

    Article  Google Scholar 

  14. Marcaccini AM, Meschiari CA, Sorgi CA et al (2009) Circulating interleukin-6 and high-sensitivity C-reactive protein decrease after periodontal therapy in otherwise healthy subjects. J Periodontol 80:594–602

    Article  PubMed  Google Scholar 

  15. Vidal F, Figueredo CM, Cordovil I, Fischer RG (2009) Periodontal therapy reduces plasma levels of interleukin-6, C-reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial hypertension. J Periodontol 80:786–791

    Article  PubMed  Google Scholar 

  16. Calabrò P, Golia E, Yeh ET (2009) CRP and the risk of atherosclerotic events. Semin Immunopathol 31:79–94

    Article  PubMed  Google Scholar 

  17. Ishigaki Y, Katagiri H, Gao J et al (2008) Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. Circulation 118:75–83

    Article  PubMed  Google Scholar 

  18. Montebugnoli L, Servidio D, Miaton RA et al (2005) Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease. J Clin Periodontol 32:188–192

    Article  PubMed  Google Scholar 

  19. Tamaki N, Tomofuji T, Ekuni D, Yamanaka R, Yamamoto T, Morita M (2009) Short-term effects of non-surgical periodontal treatment on plasma level of reactive oxygen metabolites in patients with chronic periodontitis. J Periodontol 80:901–906

    Article  PubMed  Google Scholar 

  20. Vassalle C, Pratali L, Boni C, Mercuri A, Ndreu R (2008) An oxidative stress score as a combined measure of the pro-oxidant and anti-oxidant counterparts in patients with coronary artery disease. Clin Biochem 41:1162–1167

    Article  PubMed  Google Scholar 

  21. O'Leary TJ, Drake RB, Naylor JE (1972) The plaque control record. J Periodontol 43:38

    Article  PubMed  Google Scholar 

  22. Koubaa N, Nakbi A, Smaoui M et al (2007) Hyperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients: role of genetic and dietary factors. Clin Biochem 40:1007–1014

    Article  PubMed  Google Scholar 

  23. Pepys MB, Hirschfield GM (2003) C-reactive protein: a critical update. J Clin Invest 111:1805–1812

    PubMed  Google Scholar 

  24. Itabe H (1998) Oxidized phospholipids as a new landmark in atherosclerosis. Prog Lipid Res 37:181–207

    Article  PubMed  Google Scholar 

  25. Witztum JL, Steinberg D (1991) Role of oxidized low density lipoprotein in atherosclerosis. J Clin Invest 88:1785–1792

    Article  PubMed  Google Scholar 

  26. Greenstein G (1984) The role of bleeding upon probing in the diagnosis of periodontal disease. A literature review. J Periodontol 55:684–688

    PubMed  Google Scholar 

  27. Matthews JB, Wright HJ, Robert A, Cooper PR, Chapple IL (2007) Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis. Clin Exp Immunol 147:255–264

    Article  PubMed  Google Scholar 

  28. O'Connell PA, Toba M, Nomizo A et al (2008) Effects of periodontal therapy on glycemic control and inflammatory markers. J Periodontol 79:774–783

    Article  PubMed  Google Scholar 

  29. Marcaccini AM, Novaes AB Jr, Meschiari CA et al (2009) Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy. Clin Chim Acta 409:117–122

    Article  PubMed  Google Scholar 

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Acknowledgements

This work was supported by Grants-in-Aid for Scientific Research (20791641 & 22792119) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Naofumi Tamaki, Takaaki Tomofuji, Daisuke Ekuni, Reiko Yamanaka & Manabu Morita

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  1. Naofumi Tamaki
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  2. Takaaki Tomofuji
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  3. Daisuke Ekuni
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  4. Reiko Yamanaka
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  5. Manabu Morita
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Correspondence to Takaaki Tomofuji.

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Tamaki, N., Tomofuji, T., Ekuni, D. et al. Periodontal treatment decreases plasma oxidized LDL level and oxidative stress. Clin Oral Invest 15, 953–958 (2011). https://doi.org/10.1007/s00784-010-0458-y

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  • DOI: https://doi.org/10.1007/s00784-010-0458-y

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