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The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction

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Summary.

A baculoviral mammalian-cell vector was constructed to express Rta, a protein of Epstein-Barr virus (EBV) responsible for the transition from latent infection to lytic replication. EBV lytic replication and cell-growth inhibition was observed in infected D98/HR1 cells. The baculovirus caused little cytotoxicity in the non-targeted HeLa cells, compared to an adenovirus vector. It is concluded that recombinant baculovirus might have the potential as a vector for the therapy of EBV-related cancer.

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Authors and Affiliations

  1. Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China

    L. Wang, L. Shan, J. Yin, M. Zhao, D. Su & J. Zhong

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  1. L. Wang
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  2. L. Shan
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  3. J. Yin
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  4. M. Zhao
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  5. D. Su
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  6. J. Zhong
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Wang, L., Shan, L., Yin, J. et al. The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction. Arch Virol 151, 2047–2053 (2006). https://doi.org/10.1007/s00705-006-0772-5

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  • DOI: https://doi.org/10.1007/s00705-006-0772-5

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