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Transgenic animal models of neurodegeneration based on human genetic studies

  • Basic Neurosciences, Genetics and Immunology - Review Article
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Abstract

The identification of genes linked to neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD) and Parkinson’s disease (PD) has led to the development of animal models for studying mechanism and evaluating potential therapies. None of the transgenic models developed based on disease-associated genes have been able to fully recapitulate the behavioral and pathological features of the corresponding disease. However, there has been enormous progress made in identifying potential therapeutic targets and understanding some of the common mechanisms of neurodegeneration. In this review, we will discuss transgenic animal models for AD, ALS, HD and PD that are based on human genetic studies. All of the diseases discussed have active or complete clinical trials for experimental treatments that benefited from transgenic models of the disease.

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Acknowledgments

The authors thank Dr. Marc Halterman for his recommendations on the table. This work was supported by the Intramural Research Program at the National Institute on Drug Abuse.

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  1. Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA

    Brandon K. Harvey, Christopher T. Richie, Barry J. Hoffer & Mikko Airavaara

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  1. Brandon K. Harvey
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Correspondence to Brandon K. Harvey.

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Harvey, B.K., Richie, C.T., Hoffer, B.J. et al. Transgenic animal models of neurodegeneration based on human genetic studies. J Neural Transm 118, 27–45 (2011). https://doi.org/10.1007/s00702-010-0476-6

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