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Dopamine and N-methyl-D-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal

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Summary

The aim of the present pilot study was to explore whether a change in cerebral receptors can be demonstrated in human peripheral blood lymphocytes during alcohol withdrawal. Dopamine (D1 and D2) and NMDA (1 and 2B) receptor expressions of 14 male patients suffering from alcohol-dependency were assessed through quantitative RT-PCR. A significant difference in D1 receptor expression (T = 2.361; p = 0.035) in terms of up-regulation could be shown, though there were no significant changes concerning D2, NMDA1 or NMDA2B receptor expression.

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References

  • JD Berke SE Hyman (2000) ArticleTitleAddiction, dopamine, and the molecular mechanisms of memory Neuron 25 515–532 10.1016/S0896-6273(00)81056-9 Occurrence Handle10.1016/S0896-6273(00)81056-9 Occurrence Handle1:CAS:528:DC%2BD3cXisFKrtLw%3D Occurrence Handle10774721

    Article  CAS  PubMed  Google Scholar 

  • S Bleich M Carl K Bayerlein U Reulbach T Biermann T Hillemacher D Bönsch J Kornhuber (2005) ArticleTitleEvidence of increased homocysteine levels in alcoholism: The Franconian Alcoholism Research Studies (FARS) Alcohol Clin Exp Res 29 334–336 10.1097/01.ALC.0000156083.91214.59 Occurrence Handle10.1097/01.ALC.0000156083.91214.59 Occurrence Handle1:CAS:528:DC%2BD2MXit1Omtb4%3D Occurrence Handle15770107

    Article  CAS  PubMed  Google Scholar 

  • ML Cravo LM Gloria J Selhub MR Nadeau ME Camilo MP Resende JN Cardoso CN Leitao FC Mira (1996) ArticleTitleHyperhomocysteinemia in chronic alcoholism. Correlation with folate, vitamin B-12, and vitamin B-6 status Am J Clin Nutr 63 220–224 Occurrence Handle1:CAS:528:DyaK28XhsFKmu7g%3D Occurrence Handle8561063

    CAS  PubMed  Google Scholar 

  • C Czermak M Lehofer EM Wagner B Prietl L Lemonis A Rohrhofer K Schauenstein PM Liebmann (2004) ArticleTitleReduced dopamine D4 receptor mRNA expression in lymphocytes of long-term abstinent alcohol and heroin addicts Addiction 99 251–257 10.1111/j.1360-0443.2003.00621.x Occurrence Handle10.1111/j.1360-0443.2003.00621.x Occurrence Handle14756717

    Article  PubMed  Google Scholar 

  • WK Doring MN Herzenstiel H Krampe H Jahn L Pralle S Sieg E Wegerle W Poser H Ehrenreich (2003) ArticleTitlePersistent alterations of vasopressin and N-terminal proatrial natriuretic peptide plasma levels in long-term abstinent alcoholics Alcohol Clin Exp Res 27 849–861 10.1097/01.ALC.0000065433.17403.DE Occurrence Handle10.1097/01.ALC.0000065433.17403.DE Occurrence Handle12766631

    Article  PubMed  Google Scholar 

  • F Fadda ZL Rossetti (1998) ArticleTitleChronic ethanol consumption: from neuroadaption to neurodegeneration Progr Neurobiol 56 385–431 10.1016/S0301-0082(98)00032-X Occurrence Handle10.1016/S0301-0082(98)00032-X Occurrence Handle1:CAS:528:DyaK1cXmt1eqs7c%3D

    Article  CAS  Google Scholar 

  • KA Grant LD Snell MA Rogawaksi A Thurkauf B Tabakoff (1992) ArticleTitleComparison of the effects of the uncompetitive N-methyl-D-aspartate antagonist (±)-5aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (ADCL) with its structural analogs dizocilpine (MK-801) and carbamazepine on ethanol withdrawal seizures J Pharmacol Exp Ther 260 1017–1022 Occurrence Handle1:CAS:528:DyaK38XitV2mtrc%3D Occurrence Handle1545374

    CAS  PubMed  Google Scholar 

  • HS Kalluri AK Mehta MK Ticku (1998) ArticleTitleUp-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment Mol Brain Res 58 221–224 10.1016/S0169-328X(98)00112-0 Occurrence Handle10.1016/S0169-328X(98)00112-0 Occurrence Handle1:CAS:528:DyaK1cXksV2jsLo%3D Occurrence Handle9685652

    Article  CAS  PubMed  Google Scholar 

  • YT Kwak M-S Koo C-H Choi IN Sunwoo (2001) ArticleTitleChange of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients BMC Med Gen 2 3–13 10.1186/1471-2350-2-3 Occurrence Handle10.1186/1471-2350-2-3 Occurrence Handle1:STN:280:DC%2BD3szhslCmsg%3D%3D

    Article  CAS  Google Scholar 

  • CY Li L Aguayo RW Peoples FF Weight (1994) ArticleTitleEthanol inhibits a neuronal ATP-gated ion channel Mol Pharmacol 44 871–875

    Google Scholar 

  • HJ Little (1999) ArticleTitleThe contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol Pharm Therapeutics 84 333–353 10.1016/S0163-7258(99)00040-6 Occurrence Handle10.1016/S0163-7258(99)00040-6 Occurrence Handle1:CAS:528:DyaK1MXnslGqsrg%3D

    Article  CAS  Google Scholar 

  • D Lovinger (2000) ArticleTitleExamination of ethanol, spermine and acamprosate actions on native and recombinant NMDA receptors Alcohol Clin Exp Res 24 183–187

    Google Scholar 

  • JM Maler H Esselmann J Wiltfang N Kunz P Lewczuk U Reulbach S Bleich E Rüther J Kornhuber (2005) ArticleTitleMemantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons Brain Res 1052 156–162 10.1016/j.brainres.2005.06.017 Occurrence Handle10.1016/j.brainres.2005.06.017 Occurrence Handle1:CAS:528:DC%2BD2MXns1Wmtr8%3D Occurrence Handle16009352

    Article  CAS  PubMed  Google Scholar 

  • ZL Rossetti Y Hmaidan GL Gessa (1992) ArticleTitleMarked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats Eur J Pharmac 221 227–234 10.1016/0014-2999(92)90706-A Occurrence Handle10.1016/0014-2999(92)90706-A Occurrence Handle1:CAS:528:DyaK3sXhs1Wlsw%3D%3D

    Article  CAS  Google Scholar 

  • P Seeman T Tallerico F Ko (2004) ArticleTitleAlcohol-withdrawn animals have a prolonged increase in dopamine D2High receptors, reversed by general anaesthesia: Relation to relapse? Synapse 52 77–83 10.1002/syn.20005 Occurrence Handle10.1002/syn.20005 Occurrence Handle1:CAS:528:DC%2BD2cXivFylsLg%3D Occurrence Handle15034913

    Article  CAS  PubMed  Google Scholar 

  • DW Self EJ Nestler (1995) ArticleTitleMolecular mechanisms of drug reinforcement and addiction Ann Rev Neurosci 18 463–495 10.1146/annurev.ne.18.030195.002335 Occurrence Handle10.1146/annurev.ne.18.030195.002335 Occurrence Handle1:CAS:528:DyaK2MXktl2lt7g%3D Occurrence Handle7605071

    Article  CAS  PubMed  Google Scholar 

  • GC Tsai JT Coyle (1998) ArticleTitleThe role of glutamatergic neurotransmission in the Pathophysiology of alcoholism Ann Rev Med 49 173–184 10.1146/annurev.med.49.1.173 Occurrence Handle10.1146/annurev.med.49.1.173 Occurrence Handle1:CAS:528:DyaK1cXhtFKqsr4%3D Occurrence Handle9509257

    Article  CAS  PubMed  Google Scholar 

  • GC Tsai DR Gastfriend JT Coyle (1995) ArticleTitleThe glutamatergic basis of human alcoholism Am J Psychiatry 152 332–340 Occurrence Handle1:STN:280:DyaK2M7mvVCktQ%3D%3D Occurrence Handle7864257

    CAS  PubMed  Google Scholar 

  • ND Volkow G-J Wang L Maynard JS Fowler B Jayne F Telang J Logan Y-S Ding SJ Gatley R Hitzemann C Wong N Pappas (2002) ArticleTitleEffects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study Psych Res Neuroim 116 163–172 10.1016/S0925-4927(02)00087-2 Occurrence Handle10.1016/S0925-4927(02)00087-2 Occurrence Handle1:CAS:528:DC%2BD3sXhsV2is7w%3D

    Article  CAS  Google Scholar 

  • SME Wong DL Tauck EG Fong JJ Kendig (1998) ArticleTitleGlutamate receptor-mediated hyperexcitability after ethanol exposure in isolated neonatal rat spinal cord JPET 285 201–207 Occurrence Handle1:CAS:528:DyaK1cXisVCqsro%3D

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University, Erlangen-Nuremberg, Germany

    T. Biermann, D. Bönsch, U. Reulbach, J. Kornhuber & S. Bleich

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  1. T. Biermann
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  2. D. Bönsch
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  3. U. Reulbach
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  4. J. Kornhuber
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  5. S. Bleich
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First two authors contributed equally

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Biermann, T., Bönsch, D., Reulbach, U. et al. Dopamine and N-methyl-D-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal. J Neural Transm 114, 1081–1084 (2007). https://doi.org/10.1007/s00702-007-0661-4

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  • DOI: https://doi.org/10.1007/s00702-007-0661-4

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