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Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson’s disease: an open label 24-hour polysomnographic study

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Summary.

Few studies focused on the effects of cabergoline on sleep-wake cycle in PD. Twelve patients affected by PD treated with levodopa as monotherapy underwent two 24-hour ambulatory polysomnographic (A-PSG) sessions twice: in baseline condition (levodopa as monotherapy) and after addition of cabergoline. In each condition, a subjective evaluation of sleep quality and daytime sleepiness was obtained by means of Parkinson’s disease Sleep Scale (PDSS) and the Epworth Sleepiness Scale. The statistical analysis of sleep parameters revealed a significant increase of sleep efficiency and slow wave sleep under cabergoline. The PDSS total score showed a significant improvement of overall sleep quality after cabergoline. No significant changes in daytime sleepiness were observed. No patient referred and/or showed sleep attacks before and after addition of cabergoline. We hypothesize that the long-lasting effect of cabergoline may improve the objective quality of nocturnal sleep in PD patients complaining nocturnal motor disability without inducing daytime sleepiness.

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Authors and Affiliations

  1. University of Rome “Tor Vergata” Policlinico Tor Vergata Servizio di Neurofisiopatologia Centro di Medicina del Sonno, Rome, Italy

    A. Romigi, M. G. Marciani, F. Placidi, A. Cervellino, K. Grossi & M. Pierantozzi

  2. University of Rome “Tor Vergata” Dipartimento di Neuroscienze Clinica Neurologica, Rome, Italy

    P. Stanzione, F. Izzi & L. Brusa

  3. IRCCS Fondazione Santa Lucia, Via Ardeatina 306, Rome, Italy

    A. Romigi, P. Stanzione, M. G. Marciani, F. Placidi & M. Pierantozzi

  4. Università di Roma La Sapienza, Clinica Neurologica, Rome, Italy

    P. Giacomini

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  1. A. Romigi
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  2. P. Stanzione
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  3. M. G. Marciani
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  4. F. Izzi
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Romigi, A., Stanzione, P., Marciani, M. et al. Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson’s disease: an open label 24-hour polysomnographic study. J Neural Transm 113, 1909–1913 (2006). https://doi.org/10.1007/s00702-006-0490-x

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