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Physiological and subjective responding to alcohol cue exposure in alcoholics and control subjects: evidence for appetitive responding

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Summary.

36 alcoholic patients, recruited from a treatment program, and 20 non-alcohol abusing control subjects were tested for their reactions to alcohol and non-alcohol cues. The cue exposure paradigm included audio-visual (video), tactile, olfactory, and guided imagery cue components related to alcohol and non-alcohol beverages. Response measures were analyzed for significant difference based on alcohol and non-alcohol cue and patient type. Among the subjective ratings, alcohol cue specific increases in alcohol craving, desire to drink, alcohol-like high, positive drinking expectancies and alcohol-like withdrawal were seen in alcoholic subjects. Among the physiological measures, alcohol cue specific increases in salivation were seen in alcoholic subjects. Changes in heart rate, skin conductance and temperature were not specific to alcohol cues, or to alcoholic patients. The smelling of alcohol had the greatest impact on alcohol craving and skin conductance in alcoholic subjects. These findings demonstrate robust subjective effects, and weak physiological effects, in response to a multidimensional alcohol cue exposure paradigm. The response profile indicates cue reactivity in alcoholics as an appetitive based form of alcohol craving.

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References

  • InstitutionalAuthorNameAmerican Psychiatric Association (1994) Diagnostic and statistical manual of mental disorder DSM-IV EditionNumberfourth American Psychiatric Association Washington DC

    Google Scholar 

  • RF Anton DH Moak P Latham (1995) ArticleTitleThe obsessive-compulsive drinking scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior Alcohol Clin Exp Res 19 92–99 Occurrence Handle7771669 Occurrence Handle1:STN:280:DyaK2M3ovFKjtA%3D%3D Occurrence Handle10.1111/j.1530-0277.1995.tb01475.x

    Article  PubMed  CAS  Google Scholar 

  • AT Beck (1978) Beck Depression Inventory SeriesTitleThe Psychological Corporation Harcourt Brace & Company San Antonio

    Google Scholar 

  • SP Berger SM Hall JD Mickalian MS Reid CA Crawford KL Delucchi K Carr S Hall (1996) ArticleTitleHaloperidol antagonism of cue-elicited cocaine craving Lancet 347 504–508 Occurrence Handle8596268 Occurrence Handle1:CAS:528:DyaK28XhvFClurg%3D Occurrence Handle10.1016/S0140-6736(96)91139-3

    Article  PubMed  CAS  Google Scholar 

  • Binkoff JA, Abrams DB, Collins RL, Liepman MR, Monti PM, Nirenberg TD, Zwick WR (1984) Exposure to alcohol cues. Comunicación pre- sentada en The Association for Advancement of Behavior Therapy, Filadelfia

  • MJ Bohn DD Krahn BA Staehler (1995) ArticleTitleDevelopment and initial validation of a measure of drinking urges in abstinent alcoholics Alcohol Clin Exp Res 3 600–606 Occurrence Handle10.1111/j.1530-0277.1995.tb01554.x

    Article  Google Scholar 

  • DF Braus J Wrase S Grusser D Herman M Ruf H Flor K Mann A Heinz (2001) ArticleTitleAlcohol associated stimuli activate ventral striatum in abstinent alcoholics J Neural Transm 108 887–894 Occurrence Handle11515754 Occurrence Handle1:STN:280:DC%2BD3MvntVygsw%3D%3D Occurrence Handle10.1007/s007020170038

    Article  PubMed  CAS  Google Scholar 

  • AR Childress D Mozley W McElgin J Fitzgerald M Reivich CP O’Brien (1999) ArticleTitleLimbic activation during cue-induced cocaine craving Am J Psychiatry 156 11–18 Occurrence Handle9892292 Occurrence Handle1:STN:280:DyaK1M7gsleisg%3D%3D

    PubMed  CAS  Google Scholar 

  • NL Cooney RA Gillespie LH Baker RF Kaplan (1987) ArticleTitleCognitive changes after alcohol cue exposure J Consult Clin Psychol 55 150–155 Occurrence Handle3571667 Occurrence Handle1:STN:280:DyaL2s7psFOhuw%3D%3D Occurrence Handle10.1037/0022-006X.55.2.150

    Article  PubMed  CAS  Google Scholar 

  • DC Drummond (1990) ArticleTitleThe relationship between alcohol dependence and alcohol-related problems in a clinical population Br J Addict 85 357–366 Occurrence Handle2334822 Occurrence Handle1:STN:280:DyaK3c3kt1Whtg%3D%3D Occurrence Handle10.1111/j.1360-0443.1990.tb00652.x

    Article  PubMed  CAS  Google Scholar 

  • DC Drummond T Cooper SP Glautier (1990) ArticleTitleConditioned learning in alcohol dependence: implications for cue exposure treatment Br J Addict 85 725–743 Occurrence Handle2198966 Occurrence Handle1:STN:280:DyaK3czjsFClsg%3D%3D Occurrence Handle10.1111/j.1360-0443.1990.tb01685.x

    Article  PubMed  CAS  Google Scholar 

  • BA Flannery JR Volpicelli HM Pettinati (1999) ArticleTitlePsychometric properties of the Penn Alcohol Craving Scale Alcohol Clin Exp Res 23 1289–1295 Occurrence Handle10470970 Occurrence Handle1:STN:280:DyaK1MzpslGksw%3D%3D Occurrence Handle10.1111/j.1530-0277.1999.tb04349.x

    Article  PubMed  CAS  Google Scholar 

  • MS George RF Raymond C Bloomer C Teneback DJ Drobes JP Lorberbaum Z Nahas DJ Vincent (2001) ArticleTitleActivation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues Arch Gen Psychiatry 58 345–352 Occurrence Handle11296095 Occurrence Handle1:STN:280:DC%2BD3M3itVGhsg%3D%3D Occurrence Handle10.1001/archpsyc.58.4.345

    Article  PubMed  CAS  Google Scholar 

  • S Glautier DC Drummond (1994) ArticleTitleAlcohol dependence and cue reactivity J Stud Alcohol 55 224–229 Occurrence Handle8189743 Occurrence Handle1:STN:280:DyaK2c3ks12ktA%3D%3D

    PubMed  CAS  Google Scholar 

  • S Grant ED London DB Newlin VL Villemagne X Liu C Contoreggi RL Phillips AS Kimes A Margolin (1996) ArticleTitleActivation of memory circuits during cue-elicited cocaine craving Proc Natl Acad Sci USA 93 12040–12045 Occurrence Handle8876259 Occurrence Handle1:CAS:528:DyaK28Xmtlaqs7o%3D Occurrence Handle10.1073/pnas.93.21.12040

    Article  PubMed  CAS  Google Scholar 

  • SM Grusser J Wrase S Klain D Hermann MN Smolka M Ruf W Weber-Fahr H Flor K Mann DF Braus A Heinz (2004) ArticleTitleCue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics Psychopharmacology 175 296–302 Occurrence Handle15127179 Occurrence Handle10.1007/s00213-004-1828-4 Occurrence Handle1:CAS:528:DC%2BD2cXotVOhtr8%3D

    Article  PubMed  CAS  Google Scholar 

  • A Heinz S Lober A Georgi J Wrase D Herman ER Rey S Wellek K Mann (2003) ArticleTitleReward craving and withdrawal relief craving: assessment of different motivational pathways to alcohol intake Alcoholism Alcohol 38 35–39 Occurrence Handle10.1093/alcalc/agg005

    Article  Google Scholar 

  • A Heinz T Siessmer J Wrase HG Buchholz G Grunder Y Kumakura P Cumming M Schreckenberger MN Smolka F Rosch K Mann P Bartenstein (2005) ArticleTitleCorrelation of alcohol craving with striatal dopamine synthesis capacity and D2/D3 receptor availability: a combined (18F) DOPA and (18F) DMFP PET study in detoxified alcoholic patients Am J Psychiatry 162 1515–1520 Occurrence Handle16055774 Occurrence Handle10.1176/appi.ajp.162.8.1515

    Article  PubMed  Google Scholar 

  • CN Johnson K Fromme (1994) ArticleTitleAn experimental test of affect, subjective craving, and alcohol outcome expectancies as motivators of young adult drinking Addict Behav 19 631–641 Occurrence Handle7701974 Occurrence Handle1:STN:280:DyaK2M3hs1Ggtg%3D%3D Occurrence Handle10.1016/0306-4603(94)90018-3

    Article  PubMed  CAS  Google Scholar 

  • N Kambouropoulos PK Staiger (2004) ArticleTitleReactivity to alcohol cues: relationship among cue types, motivation process and personality Psychol Addict Behav 18 275–283 Occurrence Handle15482083 Occurrence Handle10.1037/0893-164X.18.3.275

    Article  PubMed  Google Scholar 

  • RF Kaplan RF Meyer CF Stroebel (1983) ArticleTitleAlcohol dependence and responsivity to an ethanol stimulus as predictors of alcohol consumption Br J Addict 78 259–267 Occurrence Handle6578828 Occurrence Handle1:STN:280:DyaL2c%2FisVensg%3D%3D Occurrence Handle10.1111/j.1360-0443.1983.tb02510.x

    Article  PubMed  CAS  Google Scholar 

  • JC Laberg (1990) ArticleTitleWhat is presented, and what prevented, in cue exposure and response prevention in alcohol dependent patients? Addict Behav 15 367–386 Occurrence Handle2248110 Occurrence Handle1:STN:280:DyaK3M%2Fmtlaisw%3D%3D Occurrence Handle10.1016/0306-4603(90)90046-Z

    Article  PubMed  CAS  Google Scholar 

  • JC Laberg B Ellertson (1987) ArticleTitlePsychophysiological indicators of craving in alcoholics: effects of cue exposure Br J Addict 82 1341–1348 Occurrence Handle3480748 Occurrence Handle1:STN:280:DyaL1c7gslelug%3D%3D Occurrence Handle10.1111/j.1360-0443.1987.tb00437.x

    Article  PubMed  CAS  Google Scholar 

  • MD Litt NL Cooney (1999) ArticleTitleInducing craving for alcohol in the laboratory Alcohol Res and Health 23 174–178 Occurrence Handle1:STN:280:DC%2BD3czos1WnsQ%3D%3D

    CAS  Google Scholar 

  • MD Litt NL Cooney P Morse (2000) ArticleTitleReactivity to alcohol-related stimuli in the laboratory and in the field: predictors of craving in treated alcoholics Addiction 95 889–900 Occurrence Handle10946438 Occurrence Handle1:STN:280:DC%2BD3cvgvFCgsA%3D%3D Occurrence Handle10.1046/j.1360-0443.2000.9568896.x

    Article  PubMed  CAS  Google Scholar 

  • AM Ludwig A Wikler LH Stark (1974) ArticleTitleThe first drink. Physiological aspects of craving Arch Gen Psychiatry 30 539–547 Occurrence Handle4131353 Occurrence Handle1:STN:280:DyaE2c7htlyltg%3D%3D

    PubMed  CAS  Google Scholar 

  • GA Marlatt (1985) Cognitive factors in the relapse process GA Marlatt JR Gordon (Eds) Relapse prevention: maintenance strategies in the treatment of addictive behaviors Guilford Press New York 128–200

    Google Scholar 

  • GA Marlatt JR Gordon (1985) Relapse prevention: maintenance strategies in the treatment of addictive behaviors Guilford Press New York 3–70

    Google Scholar 

  • ME McCaul JS Turkkan ML Stitzer (1989a) ArticleTitlePsychophysiological effects of alcohol-related stimuli. I. The role of stimulus intensity Alcoholism Clin Exp Res 13 386–398 Occurrence Handle1:STN:280:DyaL1MzitFSjsw%3D%3D Occurrence Handle10.1111/j.1530-0277.1989.tb00340.x

    Article  CAS  Google Scholar 

  • ME McCaul JS Turkkan ML Stitzer (1989b) ArticleTitleConditioned opponent responses: effects of placebo challenge in alcoholic subjects Alcoholism Clin Exp Res 13 631–635 Occurrence Handle1:STN:280:DyaK3c%2Foslagtw%3D%3D Occurrence Handle10.1111/j.1530-0277.1989.tb00395.x

    Article  CAS  Google Scholar 

  • CG McCusker K Brown (1990) ArticleTitleAlcohol-predictive cues enhance tolerance to and precipitate “craving” for alcohol in social drinkers J Studies Alcohol 51 494–499 Occurrence Handle1:STN:280:DyaK3M7gtFCksg%3D%3D

    CAS  Google Scholar 

  • CG McCusker K Brown (1995) ArticleTitleCue-exposure to alcohol-associated stimuli reduces autonomic reactivity, but not craving and anxiety, in dependent drinkers Alcohol Alcoholism 30 319–327 Occurrence Handle1:STN:280:DyaK28%2FltlOqug%3D%3D

    CAS  Google Scholar 

  • AT McLellan L Luborsky CP O’Brien GE Woody (1980) ArticleTitleAn improved evaluation instrument for substance abuse patients: the Addiction Severity Index J Nerv Ment Dis 168 26–33 Occurrence Handle7351540 Occurrence Handle1:STN:280:DyaL3c%2Fps1Srsw%3D%3D

    PubMed  CAS  Google Scholar 

  • NS Miller MS Gold (1994) ArticleTitleDissociation of “conscious desire” (craving) from and relapse in alcohol and cocaine dependence Ann Clin Psych 6 99–106 Occurrence Handle1:STN:280:DyaK2M7gt1Ortg%3D%3D

    CAS  Google Scholar 

  • JG Modell FB Glaser JM Mountz S Schmaltz L Cyr (1992a) ArticleTitleObsessive compulsive characteristics of alcohol abuse and dependence: quantification by a newly developed questionnaire Alcohol Clin Exp Res 16 266–271 Occurrence Handle1:STN:280:DyaK383nt1eqsg%3D%3D Occurrence Handle10.1111/j.1530-0277.1992.tb01374.x

    Article  CAS  Google Scholar 

  • JG Modell FB Glaser L Cyr JM Mountz (1992b) ArticleTitleObsessive and compulsive characterisitics of craving in alcohol abuse and dependence Alcohol Clin Exp Res 16 272–274 Occurrence Handle1:STN:280:DyaK383nt1eqsw%3D%3D Occurrence Handle10.1111/j.1530-0277.1992.tb01375.x

    Article  CAS  Google Scholar 

  • JG Modell JM Mountz (1995) ArticleTitleFocal cerebral blood flow change during craving for alcohol measured by SPECT J Neuropsychiatr Clin Neurosci 7 15–22 Occurrence Handle1:STN:280:DyaK2M3is1yqtA%3D%3D

    CAS  Google Scholar 

  • PM Monti JA Binkoff DB Abrams WR Zwick TD Nirenberg MR Liebman (1987) ArticleTitleReactivity of alcoholics and non-alcoholics to drinking cues J Abnorm Psychol 96 122–126 Occurrence Handle3584660 Occurrence Handle1:STN:280:DyaL2s3itlCktA%3D%3D Occurrence Handle10.1037/0021-843X.96.2.122

    Article  PubMed  CAS  Google Scholar 

  • RF Mucha A Geier P Pauli (1999) ArticleTitleModulation of craving by cues having differential overlap with pharmacological effect: evidence for cue approach in smokers and social drinkers Psychopharmacol 147 306–313 Occurrence Handle1:CAS:528:DC%2BD3cXpslKrtw%3D%3D Occurrence Handle10.1007/s002130051172

    Article  CAS  Google Scholar 

  • RF Mucha A Geier M Stuhlinger G Mundle (2000) ArticleTitleAppetitive effects of drug cues modeled by pictures of the intake ritual: generally of cue-modulated startle examined with inpatient alcoholics Psychopharmacol 151 428–432 Occurrence Handle1:CAS:528:DC%2BD3cXntVaqu78%3D Occurrence Handle10.1007/s002130000508

    Article  CAS  Google Scholar 

  • CP O’Brien AR Childress R Ehrman SJ Robbins (1998) ArticleTitleConditioning factors in drug abuse: can they explain compulsion? J Psychopharm 12 15–22 Occurrence Handle1:STN:280:DyaK1c3ksVemtw%3D%3D

    CAS  Google Scholar 

  • OF Pommerleau J Fertig L Baker N Cooney (1983) ArticleTitleReactivity to alcohol cues in alcoholics and non-alcoholics: implications for a stimulus control analysis of drinking Addict Behav 8 1–10 Occurrence Handle10.1016/0306-4603(83)90048-5

    Article  Google Scholar 

  • BC Rather MS Goldman L Roehrich M Brannick (1992) ArticleTitleEmpirical modeling of an alcohol expectancy memory network using multidimensional scaling J Abnorm Psychol 101 174–183 Occurrence Handle1537963 Occurrence Handle1:STN:280:DyaK387ms1Wjtg%3D%3D Occurrence Handle10.1037/0021-843X.101.1.174

    Article  PubMed  CAS  Google Scholar 

  • MS Reid JD Mickalian KL Delucchi SM Hall SP Berger (1998) ArticleTitleAn acute dose of nicotine enhances cue-induced cocaine craving Drug Alcohol Depend 49 95–104 Occurrence Handle9543646 Occurrence Handle1:CAS:528:DyaK1cXnt1ymtg%3D%3D Occurrence Handle10.1016/S0376-8716(97)00144-0

    Article  PubMed  CAS  Google Scholar 

  • MS Reid L Prichep S O’Leary D Ciplet ML Tom B Howard J Rotrosen R John (2003) ArticleTitleQuantitative electroencephalographic studies of cue-induced cocaine craving Clinical EEG 34 110–123

    Google Scholar 

  • MS Reid JD Mickalian KL Delucchi SP Berger (1999) ArticleTitleA nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent subjects Neuropsychopharmacology 20 297–307 Occurrence Handle10063490 Occurrence Handle1:CAS:528:DyaK1MXhsleis70%3D Occurrence Handle10.1016/S0893-133X(98)00076-1

    Article  PubMed  CAS  Google Scholar 

  • DJ Rohsenow PM Monti DB Abrams AV Rubonis RS Niaura AD Sirota SM Colby (1992) ArticleTitleCue elicited urge to drink and salivation in alcoholics: relationship to individual differences Adv Behav Res Ther 14 195–210 Occurrence Handle10.1016/0146-6402(92)90008-C

    Article  Google Scholar 

  • DJ Rohsenow PM Monti AV Rubonis AD Sirota RS Niaura SM Colby SM Wunschel DB Abrams (1994) ArticleTitleCue reactivity as a predictor of drinking among male alcoholics J Consult Clin Psychol 62 620–626 Occurrence Handle8063989 Occurrence Handle1:STN:280:DyaK2czkt1GlsQ%3D%3D Occurrence Handle10.1037/0022-006X.62.3.620

    Article  PubMed  CAS  Google Scholar 

  • DJ Rohsenow PM Monti (1999) ArticleTitleDoes urge to drink predict relapse after treatment? Alcohol Res Health 23 225–232 Occurrence Handle10890818 Occurrence Handle1:STN:280:DC%2BD3czos1Wnuw%3D%3D

    PubMed  CAS  Google Scholar 

  • AV Rubonis SM Colby PM Monti DJ Rohsenow SB Gulliver AD Sirota (1994) ArticleTitleAlcohol cue reactivity and mood induction in male and female alcoholics J Stud Alcohol 55 487–494 Occurrence Handle7934057 Occurrence Handle1:STN:280:DyaK2M%2FhvFKluw%3D%3D

    PubMed  CAS  Google Scholar 

  • EM Sellers H Kalant (1976) ArticleTitleAlcohol intoxication and withdrawal N Engl J Med 294 757–762 Occurrence Handle3733 Occurrence Handle10.1056/NEJM197604012941405

    Article  PubMed  Google Scholar 

  • S Siegel (1979) The role of conditioning in drug tolerance and addiction DJ Keehn (Eds) Psychopathology in animals: research and clinical implications Academic Press New York 143–168

    Google Scholar 

  • R Sinha T Fuse LR Aubin SS O’Malley (2000) ArticleTitlePsychological stress, drug-related cues and cocaine craving Psychopharmacol 152 140–148 Occurrence Handle1:CAS:528:DC%2BD3cXnvF2iurk%3D Occurrence Handle10.1007/s002130000499

    Article  CAS  Google Scholar 

  • PR Stasiewicz SB Gulliver CM Bradizza DJ Rohsenow R Torrisi PM Monti (1997) ArticleTitleExposure to negative emotional cues and alcohol cue reactivity with alcoholics: a preliminary investigation Behav Res Ther 35 1143–1149 Occurrence Handle9465448 Occurrence Handle1:STN:280:DyaK1c7is1GqtA%3D%3D Occurrence Handle10.1016/S0005-7967(97)00047-8

    Article  PubMed  CAS  Google Scholar 

  • J Stewart H de Wit R Eikelboom (1984) ArticleTitleRole of unconditioned and conditioned drug effects on the self-administration of opiates and stimulants Psychol Rev 91 251–268 Occurrence Handle6571424 Occurrence Handle1:STN:280:DyaL2s7kslOhuw%3D%3D Occurrence Handle10.1037/0033-295X.91.2.251

    Article  PubMed  CAS  Google Scholar 

  • T Stockwell R Hodgson G Edwards C Taylor H Rankin (1979) ArticleTitleThe development of a questionnaire to measure severity of alcohol dependence Br J Addict 74 79–87 Occurrence Handle1:STN:280:DyaE1M7isVGnuw%3D%3D Occurrence Handle10.1111/j.1360-0443.1979.tb02415.x

    Article  CAS  Google Scholar 

  • KM Stormark JC Laberg T Bjerland H Nordby K Hugdahl (1995) ArticleTitleAutonomic cued reactivity in alcoholics: the effect of olfactory stimuli Addict Behav 20 571–584 Occurrence Handle8712055 Occurrence Handle1:STN:280:DyaK287htlSjtA%3D%3D Occurrence Handle10.1016/0306-4603(95)00017-7

    Article  PubMed  CAS  Google Scholar 

  • CC Streeter SB Gulliver E Baker SR Blank AA Meyer DA Ciraulo PF Renshaw (2002) ArticleTitleVideotaped cue for urge to drink alcohol Alcohol Clin Exp Res 26 627–634 Occurrence Handle12045470 Occurrence Handle10.1111/j.1530-0277.2002.tb02584.x

    Article  PubMed  Google Scholar 

  • JT Sullivan K Sykora J Schneiderman CA Naranjo EM Sellers (1989) ArticleTitleAssessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar) Br J Addict 84 1353–1357 Occurrence Handle2597811 Occurrence Handle1:STN:280:DyaK3c%2FovFKnsg%3D%3D Occurrence Handle10.1111/j.1360-0443.1989.tb00737.x

    Article  PubMed  CAS  Google Scholar 

  • A Szegedi B Lorch A Scheurich A Ruppe M Hautzinger H Wetzel (2000) ArticleTitleCue exposure in alcohol dependent patients: preliminary evidence for different types of cue reactivity J Neural Transm 107 721–730 Occurrence Handle10943912 Occurrence Handle1:STN:280:DC%2BD3M%2FkvVGitA%3D%3D Occurrence Handle10.1007/s007020070073

    Article  PubMed  CAS  Google Scholar 

  • ST Tiffany BL Carter EG Singleton (2000) ArticleTitleChallenges in manipulation, assessment and interpretation of craving relevant variables Addiction 95 S177–S187 Occurrence Handle11002913 Occurrence Handle10.1080/09652140050111753

    Article  PubMed  Google Scholar 

  • JS Turkkan ME McCaul ML Stitzer (1989) ArticleTitlePsychophysiological effects of alcohol-related stimuli. II. Enhancement with alcohol availability Alcohol Clin Exp Res 13 392–398 Occurrence Handle2665554 Occurrence Handle1:STN:280:DyaL1MzitFSjsA%3D%3D Occurrence Handle10.1111/j.1530-0277.1989.tb00341.x

    Article  PubMed  CAS  Google Scholar 

  • VS Westerberg (2000) ArticleTitleConstituents of craving in a clinical alcohol sample J Subst Abuse 12 415–423 Occurrence Handle11452843 Occurrence Handle1:STN:280:DC%2BD3MvgtF2kug%3D%3D Occurrence Handle10.1016/S0899-3289(01)00051-7

    Article  PubMed  CAS  Google Scholar 

  • A Wikler (1965) Conditioning factors in opiate addiction and relapse DI Wiher G Kassebaum (Eds) Narcotics McGraw Hill New York

    Google Scholar 

  • J Wrase SM Grusser S Klein C Diener D Hermann H Flor K Mann DF Braus A Heinz (2002) ArticleTitleDevelopment of alcohol-associated cues and cue-induced brain activation in alcoholics Eur Psychiatry 17 287–291 Occurrence Handle12381499 Occurrence Handle1:STN:280:DC%2BD38nisVSktg%3D%3D Occurrence Handle10.1016/S0924-9338(02)00676-4

    Article  PubMed  CAS  Google Scholar 

  • R Verheul W Van den Brink P Geerlings (1999) ArticleTitleA three-way psychobiological model of craving for alcohol Alcohol Alcoholism 34 197–222 Occurrence Handle1:CAS:528:DyaK1MXjs1ansL0%3D Occurrence Handle10.1093/alcalc/34.2.197

    Article  CAS  Google Scholar 

  • M Zack T Toneatto CM MacLeod (2002) ArticleTitleAnxiety and explicit alcohol-related memory in problem drinkers Addict Behav 27 331–343 Occurrence Handle12118624 Occurrence Handle10.1016/S0306-4603(01)00233-7

    Article  PubMed  Google Scholar 

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  1. Department of Psychiatry, New York University School of Medicine, New York, NY, USA

    M. S. Reid, F. Flammino, A. Starosta & J. Palamar

  2. Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

    J. Franck

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Reid, M., Flammino, F., Starosta, A. et al. Physiological and subjective responding to alcohol cue exposure in alcoholics and control subjects: evidence for appetitive responding. J Neural Transm 113, 1519–1535 (2006). https://doi.org/10.1007/s00702-005-0439-5

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