Skip to main content

Advertisement

SpringerLink
Log in

Sclerosing angiomatoid nodular transformation of the spleen related to IgG4-associated disease: report of a case

  • Case Report
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign vascular mass, with fewer than 100 cases documented. It is generally recognized as a vascular lesion that develops in the red pulp of the spleen; however, its pathogenesis is not clearly defined. We report a case of SANT of the spleen, which presents evidence to support the hypothesis that this disease entity is associated with IgG4-associated disease. Microscopically, the tumor was composed of multiple vascular structures separated by fibrous connective tissue and immunohistochemical examination revealed positive staining for CD31, CD34, factor VIII, and IgG4. Further research based on large number of cases is warranted to clarify the pathogenesis of this tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Weinreb I, Bailey D, Battaglia D, Kennedy M, Perez-Ordonez B. CD30 and Epstein–Barr virus RNA expression in sclerosing angiomatoid nodular transformation of spleen. Virchows Arch. 2007;451(1):73–9.

    Article  PubMed  CAS  Google Scholar 

  2. Martel M, Cheuk W, Lombardi L, Lifschitz-Mercer B, Chan JK, Rosai J. Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion. Am J Surg Pathol. 2004;28(10):1268–79.

    Article  PubMed  Google Scholar 

  3. Lee D, Wood B, Formby M, Cho T. F-18 FDG-avid sclerosing angiomatoid nodular transformation (SANT) of the spleen: case study and literature review. Pathology. 2007;39(1):181–3.

    Article  PubMed  Google Scholar 

  4. Diebold J, Le Tourneau A, Marmey B, Prevot S, Muller-Hermelink HK, Sevestre H, et al. Is sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp identical to inflammatory pseudotumor? Report of 16 cases. Histopathology. 2008;53(3):299–310.

    Article  PubMed  CAS  Google Scholar 

  5. Kashiwagi S, Kumasaka T, Bunsei N, Fukumura Y, Yamasaki S, Abe K, et al. Detection of Epstein–Barr virus-encoded small RNA-expressed myofibroblasts and IgG4-producing plasma cells in sclerosing angiomatoid nodular transformation of the spleen. Virchows Arch. 2008;453(3):275–82.

    Article  PubMed  CAS  Google Scholar 

  6. Nagai Y, Hayama N, Kishimoto T, Furuya M, Takahashi Y, Otsuka M, et al. Predominance of IgG4+ plasma cells and CD68 positivity in sclerosing angiomatoid nodular transformation (SANT). Histopathology. 2008;53(4):495–8.

    Article  PubMed  CAS  Google Scholar 

  7. El Demellawy D, Nasr A, Alowami S. Sclerosing angiomatoid nodular transformation of the spleen: case report. Pathol Res Pract. 2009;205(4):289–93.

    Article  PubMed  Google Scholar 

  8. Kuo TT, Chen TC, Lee LY. Sclerosing angiomatoid nodular transformation of the spleen (SANT): clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cells. Pathol Int. 2009;59(12):844–50.

    Article  PubMed  Google Scholar 

  9. Karaosmanoglu DA, Karcaaltincaba M, Akata D. CT and MRI findings of sclerosing angiomatoid nodular transformation of the spleen: spoke wheel pattern. Korean J Radiol. 2008;9(Suppl):S52–5.

    Article  PubMed  Google Scholar 

  10. Zeeb LM, Johnson JM, Madsen MS, Keating DP. Sclerosing angiomatoid nodular transformation. AJR Am J Roentgenol. 2009;192(5):W236–8.

    Article  PubMed  Google Scholar 

  11. Thacker C, Korn R, Millstine J, Harvin H, Van Lier Ribbink JA, Gotway MB. Sclerosing angiomatoid nodular transformation of the spleen: CT, MR, PET, and (m)Tc-sulfur colloid SPECT CT findings with gross and histopathological correlation. Abdom Imaging. 2010;35(6):683–9.

    Article  PubMed  Google Scholar 

  12. Cao JY, Zhang H, Wang WP. Ultrasonography of sclerosing angiomatoid nodular transformation in the spleen. World J Gastroenterol. 2010;16(29):3727–30.

    Article  PubMed  Google Scholar 

  13. Awamleh AA, Perez-Ordonez B. Sclerosing angiomatoid nodular transformation of the spleen. Arch Pathol Lab Med. 2007;131(6):974–8.

    PubMed  Google Scholar 

  14. Kamisawa T, Okamoto A. IgG4-related sclerosing disease. World J Gastroenterol. 2008;14(25):3948–55.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

None of authors have a conflict of interest or have received financial support.

Author information

Authors and Affiliations

  1. Department of Surgery, Chonnam National University Medical School, 322, Seoyang-ro, Hwasun-eup, Hwasun-gun, Gwangju, Jeollanam-do, 519-763, Korea

    Ho-Hyun Kim, Young-Hoe Hur, Yang-Seok Koh, Jung-Chul Kim, Hyun-Jong Kim & Chol-Kyoon Cho

  2. Department of Radiology, Chonnam National University Medical School, Gwangju, Korea

    Jin-Woong Kim

  3. Department of Pathology, Chonnam National University Medical School, Gwangju, Korea

    Young Kim & Jae-Hyuk Lee

Authors
  1. Ho-Hyun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Young-Hoe Hur
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yang-Seok Koh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jung-Chul Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hyun-Jong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jin-Woong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Young Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jae-Hyuk Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Chol-Kyoon Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chol-Kyoon Cho.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, HH., Hur, YH., Koh, YS. et al. Sclerosing angiomatoid nodular transformation of the spleen related to IgG4-associated disease: report of a case. Surg Today 43, 930–936 (2013). https://doi.org/10.1007/s00595-013-0499-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-013-0499-3

Keywords

Search

Navigation