References
LB Seeff (2002) ArticleTitleNatural history of chronic hepatitis C Hepatology 36 IssueIDSuppl 1 35–46 Occurrence Handle10.1002/hep.1840360706
InstitutionalAuthorNameHepatitis viruses (1994) IARC monographs on the evaluation of the carcinogenic risks of humans International Agency for Research on Cancer Lyon, France
D Sakamuro T Furukawa T Takegami (1995) ArticleTitleHepatitis C nonstructural protein NS3 transforms NIH 3T3 cells J Virol 69 3893–6 Occurrence Handle7745741 Occurrence Handle1:CAS:528:DyaK2MXls1yhsrk%3D
RB Ray LM Lagging K Meyer R Ray (1996) ArticleTitleHepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype J Virol 70 4438–43 Occurrence Handle8676467 Occurrence Handle1:CAS:528:DyaK28XjsFygsrc%3D
K Moriya H Fujie Y Shintani H Yotsuyanagi T Tsutsumi K Ishibashi et al. (1998) ArticleTitleThe core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice Nat Med 4 1065–7 Occurrence Handle9734402 Occurrence Handle10.1038/2053 Occurrence Handle1:CAS:528:DyaK1cXlvFGns7o%3D
H Toyoda T Kumada A Tokuda Y Horiguchi H Nakano T Honda et al. (2000) ArticleTitleLong-term follow-up of sustained responders to interferon therapy in patients with chronic hepatitis C J Viral Hepat 7 414–9 Occurrence Handle11115052 Occurrence Handle10.1046/j.1365-2893.2000.00241.x Occurrence Handle1:STN:280:DC%2BD3M3it1Oqtw%3D%3D
MW Hentze MU Muckenthaler NC Andrews (2004) ArticleTitleBalancing acts: molecular control of mammalian iron metabolism Cell 117 285–97 Occurrence Handle15109490 Occurrence Handle10.1016/S0092-8674(04)00343-5 Occurrence Handle1:CAS:528:DC%2BD2cXjvFemsbg%3D
N De Maria A Colantoni S Fagiuoli GJ Liu BK Rogers F Farinati et al. (1996) ArticleTitleAssociation between reactive oxygen species and disease activity in chronic hepatitis C Free Radic Biol Med 21 291–5 Occurrence Handle8855439 Occurrence Handle10.1016/0891-5849(96)00044-5 Occurrence Handle1:CAS:528:DyaK28XltFKisL0%3D
AM Di Bisceglie CA Axiotis JH Hoofnagle BR Bacon (1992) ArticleTitleMeasurements of iron status in patients with chronic hepatitis Gastroenterology 102 2108–13 Occurrence Handle1587431 Occurrence Handle1:STN:280:By2B28jjtFI%3D
S Haque B Chandra MA Gerber ASF Lok (1996) ArticleTitleIron overload in patients with chronic hepatitis C: a clinicopathologic study Hum Pathol 27 1277–81 Occurrence Handle8958298 Occurrence Handle10.1016/S0046-8177(96)90337-8 Occurrence Handle1:STN:280:ByiC3Mjit10%3D
Fujita N, Sugimoto R, Urawa N, Araki J, Mifuji R, Yamamoto M, et al. Hepatic iron accumulation is associated with disease progression and resistance to interferon/ribavirin combination therapy in chronic hepatitis C. J Gastroenterol Hepatol 2007 (in press)
T Isomura M Yano H Hayashi N Sakamoto (1992) ArticleTitleExcess iron in the liver of patients with chronic hepatitis C J Clin Electron Microsc 25 231–7
R Shimoda M Nagashima M Sakamoto N Yamaguchi S Hirohashi J Yokota et al. (1994) ArticleTitleIncreased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis Cancer Res 54 3171–2 Occurrence Handle8205535 Occurrence Handle1:STN:280:ByuB28rhs1Y%3D
V Paradis P Mathurin M Kollinger F Imbert-Bismut F Charlotte A Piton et al. (1997) ArticleTitleIn situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features J Clin Pathol 50 401–6 Occurrence Handle9215123 Occurrence Handle10.1136/jcp.50.5.401 Occurrence Handle1:STN:280:ByiA2MjpsVY%3D
E Larrea O Beloqui MA Munoz-Navas MP Civeira J Prieto (1998) ArticleTitleSuperoxide dismutase in patients with chronic hepatitis C virus infection Free Radic Biol Med 24 1235–41 Occurrence Handle9626579 Occurrence Handle10.1016/S0891-5849(97)00437-1 Occurrence Handle1:CAS:528:DyaK1cXjsFWhtrk%3D
S Horiike S Kawanishi M Kaito M Ning H Tanaka N Fujita et al. (2005) ArticleTitleAccumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C J Hepatol 43 403–10 Occurrence Handle16023246 Occurrence Handle10.1016/j.jhep.2005.03.026 Occurrence Handle1:CAS:528:DC%2BD2MXntVCkurg%3D
Y Sumida T Nakashima T Yoh Y Kakisaka Y Nakajima H Ishikawa et al. (2001) ArticleTitleSerum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases Liver 21 295–9 Occurrence Handle11589765 Occurrence Handle10.1034/j.1600-0676.2001.210501.x Occurrence Handle1:CAS:528:DC%2BD3MXns1yktbg%3D
S Shibutani M Takeshita AP Grollman (1991) ArticleTitleInsertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxoG Nature 349 431–4 Occurrence Handle1992344 Occurrence Handle10.1038/349431a0 Occurrence Handle1:CAS:528:DyaK3MXhsF2htL4%3D
N Fujita S Horiike R Sugimoto H Tanaka M Iwasa Y Kobayashi et al. (2007) ArticleTitleHepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C Free Radic Biol Med 42 353–62 Occurrence Handle17210448 Occurrence Handle10.1016/j.freeradbiomed.2006.11.001 Occurrence Handle1:CAS:528:DC%2BD2sXis1ehtA%3D%3D
C Puoti A Magrini T Stati P Rigato F Montagnese P Rossi et al. (1997) ArticleTitleClinical, histological, and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels Hepatology 26 1393–8 Occurrence Handle9397976 Occurrence Handle10.1002/hep.510260603 Occurrence Handle1:STN:280:DyaK1c%2FlvVGrtw%3D%3D
T Okanoue A Makiyama M Nakayama Y Sumida H Mitsuyoshi T Nakajima et al. (2005) ArticleTitleA follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase J Hepatol 43 599–605 Occurrence Handle16024129 Occurrence Handle10.1016/j.jhep.2005.04.008
M Sartori S Andorno C Rigamonti E Grossini G Nicosia R Boldorini (2000) ArticleTitleChronic hepatitis C is mild in menstruating women J Gastroenterol Hepatol 15 1411–7 Occurrence Handle11197052 Occurrence Handle10.1046/j.1440-1746.2000.02368.x Occurrence Handle1:STN:280:DC%2BD3M7jvFChtg%3D%3D
H Hayashi T Takikawa N Nishimura M Yano T Isomura N Sakamoto (1994) ArticleTitleImprovement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron Am J Gastroenterol 89 986–8 Occurrence Handle8017395 Occurrence Handle1:STN:280:ByuB1cfgtF0%3D
H Hayashi T Takikawa N Nishimura M Yano (1995) ArticleTitleSerum aminotransferase levels as an indicator of the effectiveness of venesection for chronic hepatitis C J Hepatol 22 268–71 Occurrence Handle7608476 Occurrence Handle10.1016/0168-8278(95)80278-9 Occurrence Handle1:STN:280:ByqA3s3msV0%3D
HL Bonkovsky (1997) ArticleTitleTherapy of hepatitis C: other options Hepatology 26 IssueIDSuppl 1 143–51 Occurrence Handle10.1002/hep.510260725
M Yano H Hayashi S Wakusawa F Sanae T Takikawa Y Shiono et al. (2002) ArticleTitleLong term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C Am J Gastroenterol 97 133–7 Occurrence Handle11808937 Occurrence Handle10.1111/j.1572-0241.2002.05436.x Occurrence Handle1:CAS:528:DC%2BD38XhtlamtLk%3D
M Yano H Hayashi K Yoshioka Y Kohgo H Saito Y Niitsu et al. (2004) ArticleTitleA significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan J Gastroenterol 39 570–4 Occurrence Handle15235875 Occurrence Handle10.1007/s00535-003-1344-z Occurrence Handle1:CAS:528:DC%2BD2cXlt1ylsLk%3D
M Iwasa M Kaito J Ikoma Y Kobayashi Y Tanaka K Higuchi et al. (2002) ArticleTitleDietary iron restriction improves aminotransferase levels in chronic hepatitis C patients Hepatogastroenterology 49 529–31 Occurrence Handle11995488 Occurrence Handle1:CAS:528:DC%2BD38XjslKhsrk%3D
YM Kowdley (2004) ArticleTitleIron hemochromatosis, and hepatocellular carcinoma Gastroenterology 127 IssueIDSuppl 3 79–86 Occurrence Handle10.1016/j.gastro.2004.09.019
E Mandishona AP MacPhail VR Gordeuk MA Kedda AC Paterson TA Rouault et al. (1998) ArticleTitleDietary iron overload as a risk factor for hepatocellular carcinoma in black Africans Hepatology 27 1563–6 Occurrence Handle9620327 Occurrence Handle10.1002/hep.510270614 Occurrence Handle1:STN:280:DyaK1c3otFKgtQ%3D%3D
C Borgna-Pignatti G Vergine T Lombardo MD Cappellini P Cianciulli A Maggio et al. (2004) ArticleTitleHepatocellular carcinoma in the thalassaemia syndromes Br J Haematol 124 114–7 Occurrence Handle14675416 Occurrence Handle10.1046/j.1365-2141.2003.04732.x
T Furutani K Hino M Okuda T Gondo S Nishina A Kitase et al. (2006) ArticleTitleHepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein Gastroenterology 130 2087–98 Occurrence Handle16762631 Occurrence Handle10.1053/j.gastro.2006.02.060 Occurrence Handle1:CAS:528:DC%2BD28XntVWit78%3D
K Moriya K Nakagawa T Santa Y Shintani H Fujie H Miyoshi et al. (2001) ArticleTitleOxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis Cancer Res 61 4365–70 Occurrence Handle11389061 Occurrence Handle1:CAS:528:DC%2BD3MXktlSqu7o%3D
G Gong G Waris R Tanveer A Siddiqui (2001) ArticleTitleHuman hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress and activates STAT-3 and NK-kappa B Proc Natl Acad Sci USA 98 9599–604 Occurrence Handle11481452 Occurrence Handle10.1073/pnas.171311298 Occurrence Handle1:CAS:528:DC%2BD3MXmtlCnur0%3D
M Okuda K Li MR Beard LA Showalter F Scholle SM Lemon et al. (2002) ArticleTitleMitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein Gastroenterology 122 366–75 Occurrence Handle11832451 Occurrence Handle10.1053/gast.2002.30983 Occurrence Handle1:CAS:528:DC%2BD38XhsVGns7o%3D
J Kato K Miyanishi M Kobune T Nakamura K Takada R Takimoto et al. (2007) ArticleTitleLong-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C J Gastroenterol 42 830–6 Occurrence Handle17940836 Occurrence Handle10.1007/s00535-007-2095-z Occurrence Handle1:CAS:528:DC%2BD2sXhtFyrur3J
J Kato M Kobune T Nakamura G Kuroiwa K Takada R Takimoto et al. (2001) ArticleTitleNormalization of elevated hepatic 8-hydroxy-2′-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet Cancer Res 61 8697–702 Occurrence Handle11751387 Occurrence Handle1:CAS:528:DC%2BD38Xht1Ogug%3D%3D
K Kiyosawa E Tanaka (2002) ArticleTitleCharacteristics of hepatocellular carcinoma in Japan Oncology 62 IssueIDSuppl 1 5–7 Occurrence Handle11868786 Occurrence Handle10.1159/000048269
HB El-Serag (2002) ArticleTitleHepatocellular carcinoma and hepatitis C in the united status Hepatology 36 IssueIDSuppl 1 74–83 Occurrence Handle10.1002/hep.1840360710
N Tanaka H Akira T Yamaura M Komatsu E Tanaka K Kiyosawa (2007) ArticleTitleEfficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study J Gastroenterol 42 49–55 Occurrence Handle17322993 Occurrence Handle10.1007/s00535-006-1967-y Occurrence Handle1:CAS:528:DC%2BD2sXitVOltL4%3D
K Iwata M Iwasa N Hara A Matsumoto Y Kobayashi S Watanabe et al. (2006) ArticleTitleIron content and consumption of health foods by patients with chronic hepatitis C J Gastroenterol 41 919–20 Occurrence Handle17048058 Occurrence Handle10.1007/s00535-006-1860-8
DM Frazer GJ Anderson (2003) ArticleTitleThe orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol Dis 30 288–97 Occurrence Handle12737947 Occurrence Handle10.1016/S1079-9796(03)00039-1 Occurrence Handle1:CAS:528:DC%2BD3sXjsVGmtrs%3D
E Nemeth MS Tuttle J Powelson MB Vaughn A Donovan DM Ward et al. (2004) ArticleTitleHepcidin regulates iron efflux by binding to ferroportin and inducing its internalization Science 306 2090–3 Occurrence Handle15514116 Occurrence Handle10.1126/science.1104742 Occurrence Handle1:CAS:528:DC%2BD2cXhtVOjsL3K
N Fujita R Sugimoto M Takeo N Urawa R Mifuji H Tanaka et al. (2007) ArticleTitleHepcidin expression in the liver: relatively low level in patients with chronic hepatitis C Mol Med 13 97–104 Occurrence Handle17515961 Occurrence Handle1:CAS:528:DC%2BD2sXmt12rsb4%3D
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Fujita, N., Takei, Y. Iron, hepatitis C virus, and hepatocellular carcinoma: iron reduction preaches the gospel for chronic hepatitis C. J Gastroenterol 42, 923–926 (2007). https://doi.org/10.1007/s00535-007-2110-4
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DOI: https://doi.org/10.1007/s00535-007-2110-4