Skip to main content

Advertisement

Log in

Iron, hepatitis C virus, and hepatocellular carcinoma: iron reduction preaches the gospel for chronic hepatitis C

  • Editorial
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. LB Seeff (2002) ArticleTitleNatural history of chronic hepatitis C Hepatology 36 IssueIDSuppl 1 35–46 Occurrence Handle10.1002/hep.1840360706

    Article  Google Scholar 

  2. InstitutionalAuthorNameHepatitis viruses (1994) IARC monographs on the evaluation of the carcinogenic risks of humans International Agency for Research on Cancer Lyon, France

    Google Scholar 

  3. D Sakamuro T Furukawa T Takegami (1995) ArticleTitleHepatitis C nonstructural protein NS3 transforms NIH 3T3 cells J Virol 69 3893–6 Occurrence Handle7745741 Occurrence Handle1:CAS:528:DyaK2MXls1yhsrk%3D

    PubMed  CAS  Google Scholar 

  4. RB Ray LM Lagging K Meyer R Ray (1996) ArticleTitleHepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype J Virol 70 4438–43 Occurrence Handle8676467 Occurrence Handle1:CAS:528:DyaK28XjsFygsrc%3D

    PubMed  CAS  Google Scholar 

  5. K Moriya H Fujie Y Shintani H Yotsuyanagi T Tsutsumi K Ishibashi et al. (1998) ArticleTitleThe core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice Nat Med 4 1065–7 Occurrence Handle9734402 Occurrence Handle10.1038/2053 Occurrence Handle1:CAS:528:DyaK1cXlvFGns7o%3D

    Article  PubMed  CAS  Google Scholar 

  6. H Toyoda T Kumada A Tokuda Y Horiguchi H Nakano T Honda et al. (2000) ArticleTitleLong-term follow-up of sustained responders to interferon therapy in patients with chronic hepatitis C J Viral Hepat 7 414–9 Occurrence Handle11115052 Occurrence Handle10.1046/j.1365-2893.2000.00241.x Occurrence Handle1:STN:280:DC%2BD3M3it1Oqtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  7. MW Hentze MU Muckenthaler NC Andrews (2004) ArticleTitleBalancing acts: molecular control of mammalian iron metabolism Cell 117 285–97 Occurrence Handle15109490 Occurrence Handle10.1016/S0092-8674(04)00343-5 Occurrence Handle1:CAS:528:DC%2BD2cXjvFemsbg%3D

    Article  PubMed  CAS  Google Scholar 

  8. N De Maria A Colantoni S Fagiuoli GJ Liu BK Rogers F Farinati et al. (1996) ArticleTitleAssociation between reactive oxygen species and disease activity in chronic hepatitis C Free Radic Biol Med 21 291–5 Occurrence Handle8855439 Occurrence Handle10.1016/0891-5849(96)00044-5 Occurrence Handle1:CAS:528:DyaK28XltFKisL0%3D

    Article  PubMed  CAS  Google Scholar 

  9. AM Di Bisceglie CA Axiotis JH Hoofnagle BR Bacon (1992) ArticleTitleMeasurements of iron status in patients with chronic hepatitis Gastroenterology 102 2108–13 Occurrence Handle1587431 Occurrence Handle1:STN:280:By2B28jjtFI%3D

    PubMed  CAS  Google Scholar 

  10. S Haque B Chandra MA Gerber ASF Lok (1996) ArticleTitleIron overload in patients with chronic hepatitis C: a clinicopathologic study Hum Pathol 27 1277–81 Occurrence Handle8958298 Occurrence Handle10.1016/S0046-8177(96)90337-8 Occurrence Handle1:STN:280:ByiC3Mjit10%3D

    Article  PubMed  CAS  Google Scholar 

  11. Fujita N, Sugimoto R, Urawa N, Araki J, Mifuji R, Yamamoto M, et al. Hepatic iron accumulation is associated with disease progression and resistance to interferon/ribavirin combination therapy in chronic hepatitis C. J Gastroenterol Hepatol 2007 (in press)

  12. T Isomura M Yano H Hayashi N Sakamoto (1992) ArticleTitleExcess iron in the liver of patients with chronic hepatitis C J Clin Electron Microsc 25 231–7

    Google Scholar 

  13. R Shimoda M Nagashima M Sakamoto N Yamaguchi S Hirohashi J Yokota et al. (1994) ArticleTitleIncreased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis Cancer Res 54 3171–2 Occurrence Handle8205535 Occurrence Handle1:STN:280:ByuB28rhs1Y%3D

    PubMed  CAS  Google Scholar 

  14. V Paradis P Mathurin M Kollinger F Imbert-Bismut F Charlotte A Piton et al. (1997) ArticleTitleIn situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features J Clin Pathol 50 401–6 Occurrence Handle9215123 Occurrence Handle10.1136/jcp.50.5.401 Occurrence Handle1:STN:280:ByiA2MjpsVY%3D

    Article  PubMed  CAS  Google Scholar 

  15. E Larrea O Beloqui MA Munoz-Navas MP Civeira J Prieto (1998) ArticleTitleSuperoxide dismutase in patients with chronic hepatitis C virus infection Free Radic Biol Med 24 1235–41 Occurrence Handle9626579 Occurrence Handle10.1016/S0891-5849(97)00437-1 Occurrence Handle1:CAS:528:DyaK1cXjsFWhtrk%3D

    Article  PubMed  CAS  Google Scholar 

  16. S Horiike S Kawanishi M Kaito M Ning H Tanaka N Fujita et al. (2005) ArticleTitleAccumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C J Hepatol 43 403–10 Occurrence Handle16023246 Occurrence Handle10.1016/j.jhep.2005.03.026 Occurrence Handle1:CAS:528:DC%2BD2MXntVCkurg%3D

    Article  PubMed  CAS  Google Scholar 

  17. Y Sumida T Nakashima T Yoh Y Kakisaka Y Nakajima H Ishikawa et al. (2001) ArticleTitleSerum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases Liver 21 295–9 Occurrence Handle11589765 Occurrence Handle10.1034/j.1600-0676.2001.210501.x Occurrence Handle1:CAS:528:DC%2BD3MXns1yktbg%3D

    Article  PubMed  CAS  Google Scholar 

  18. S Shibutani M Takeshita AP Grollman (1991) ArticleTitleInsertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxoG Nature 349 431–4 Occurrence Handle1992344 Occurrence Handle10.1038/349431a0 Occurrence Handle1:CAS:528:DyaK3MXhsF2htL4%3D

    Article  PubMed  CAS  Google Scholar 

  19. N Fujita S Horiike R Sugimoto H Tanaka M Iwasa Y Kobayashi et al. (2007) ArticleTitleHepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C Free Radic Biol Med 42 353–62 Occurrence Handle17210448 Occurrence Handle10.1016/j.freeradbiomed.2006.11.001 Occurrence Handle1:CAS:528:DC%2BD2sXis1ehtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  20. C Puoti A Magrini T Stati P Rigato F Montagnese P Rossi et al. (1997) ArticleTitleClinical, histological, and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels Hepatology 26 1393–8 Occurrence Handle9397976 Occurrence Handle10.1002/hep.510260603 Occurrence Handle1:STN:280:DyaK1c%2FlvVGrtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  21. T Okanoue A Makiyama M Nakayama Y Sumida H Mitsuyoshi T Nakajima et al. (2005) ArticleTitleA follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase J Hepatol 43 599–605 Occurrence Handle16024129 Occurrence Handle10.1016/j.jhep.2005.04.008

    Article  PubMed  Google Scholar 

  22. M Sartori S Andorno C Rigamonti E Grossini G Nicosia R Boldorini (2000) ArticleTitleChronic hepatitis C is mild in menstruating women J Gastroenterol Hepatol 15 1411–7 Occurrence Handle11197052 Occurrence Handle10.1046/j.1440-1746.2000.02368.x Occurrence Handle1:STN:280:DC%2BD3M7jvFChtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  23. H Hayashi T Takikawa N Nishimura M Yano T Isomura N Sakamoto (1994) ArticleTitleImprovement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron Am J Gastroenterol 89 986–8 Occurrence Handle8017395 Occurrence Handle1:STN:280:ByuB1cfgtF0%3D

    PubMed  CAS  Google Scholar 

  24. H Hayashi T Takikawa N Nishimura M Yano (1995) ArticleTitleSerum aminotransferase levels as an indicator of the effectiveness of venesection for chronic hepatitis C J Hepatol 22 268–71 Occurrence Handle7608476 Occurrence Handle10.1016/0168-8278(95)80278-9 Occurrence Handle1:STN:280:ByqA3s3msV0%3D

    Article  PubMed  CAS  Google Scholar 

  25. HL Bonkovsky (1997) ArticleTitleTherapy of hepatitis C: other options Hepatology 26 IssueIDSuppl 1 143–51 Occurrence Handle10.1002/hep.510260725

    Article  Google Scholar 

  26. M Yano H Hayashi S Wakusawa F Sanae T Takikawa Y Shiono et al. (2002) ArticleTitleLong term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C Am J Gastroenterol 97 133–7 Occurrence Handle11808937 Occurrence Handle10.1111/j.1572-0241.2002.05436.x Occurrence Handle1:CAS:528:DC%2BD38XhtlamtLk%3D

    Article  PubMed  CAS  Google Scholar 

  27. M Yano H Hayashi K Yoshioka Y Kohgo H Saito Y Niitsu et al. (2004) ArticleTitleA significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan J Gastroenterol 39 570–4 Occurrence Handle15235875 Occurrence Handle10.1007/s00535-003-1344-z Occurrence Handle1:CAS:528:DC%2BD2cXlt1ylsLk%3D

    Article  PubMed  CAS  Google Scholar 

  28. M Iwasa M Kaito J Ikoma Y Kobayashi Y Tanaka K Higuchi et al. (2002) ArticleTitleDietary iron restriction improves aminotransferase levels in chronic hepatitis C patients Hepatogastroenterology 49 529–31 Occurrence Handle11995488 Occurrence Handle1:CAS:528:DC%2BD38XjslKhsrk%3D

    PubMed  CAS  Google Scholar 

  29. YM Kowdley (2004) ArticleTitleIron hemochromatosis, and hepatocellular carcinoma Gastroenterology 127 IssueIDSuppl 3 79–86 Occurrence Handle10.1016/j.gastro.2004.09.019

    Article  Google Scholar 

  30. E Mandishona AP MacPhail VR Gordeuk MA Kedda AC Paterson TA Rouault et al. (1998) ArticleTitleDietary iron overload as a risk factor for hepatocellular carcinoma in black Africans Hepatology 27 1563–6 Occurrence Handle9620327 Occurrence Handle10.1002/hep.510270614 Occurrence Handle1:STN:280:DyaK1c3otFKgtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  31. C Borgna-Pignatti G Vergine T Lombardo MD Cappellini P Cianciulli A Maggio et al. (2004) ArticleTitleHepatocellular carcinoma in the thalassaemia syndromes Br J Haematol 124 114–7 Occurrence Handle14675416 Occurrence Handle10.1046/j.1365-2141.2003.04732.x

    Article  PubMed  Google Scholar 

  32. T Furutani K Hino M Okuda T Gondo S Nishina A Kitase et al. (2006) ArticleTitleHepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein Gastroenterology 130 2087–98 Occurrence Handle16762631 Occurrence Handle10.1053/j.gastro.2006.02.060 Occurrence Handle1:CAS:528:DC%2BD28XntVWit78%3D

    Article  PubMed  CAS  Google Scholar 

  33. K Moriya K Nakagawa T Santa Y Shintani H Fujie H Miyoshi et al. (2001) ArticleTitleOxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis Cancer Res 61 4365–70 Occurrence Handle11389061 Occurrence Handle1:CAS:528:DC%2BD3MXktlSqu7o%3D

    PubMed  CAS  Google Scholar 

  34. G Gong G Waris R Tanveer A Siddiqui (2001) ArticleTitleHuman hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress and activates STAT-3 and NK-kappa B Proc Natl Acad Sci USA 98 9599–604 Occurrence Handle11481452 Occurrence Handle10.1073/pnas.171311298 Occurrence Handle1:CAS:528:DC%2BD3MXmtlCnur0%3D

    Article  PubMed  CAS  Google Scholar 

  35. M Okuda K Li MR Beard LA Showalter F Scholle SM Lemon et al. (2002) ArticleTitleMitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein Gastroenterology 122 366–75 Occurrence Handle11832451 Occurrence Handle10.1053/gast.2002.30983 Occurrence Handle1:CAS:528:DC%2BD38XhsVGns7o%3D

    Article  PubMed  CAS  Google Scholar 

  36. J Kato K Miyanishi M Kobune T Nakamura K Takada R Takimoto et al. (2007) ArticleTitleLong-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C J Gastroenterol 42 830–6 Occurrence Handle17940836 Occurrence Handle10.1007/s00535-007-2095-z Occurrence Handle1:CAS:528:DC%2BD2sXhtFyrur3J

    Article  PubMed  CAS  Google Scholar 

  37. J Kato M Kobune T Nakamura G Kuroiwa K Takada R Takimoto et al. (2001) ArticleTitleNormalization of elevated hepatic 8-hydroxy-2′-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet Cancer Res 61 8697–702 Occurrence Handle11751387 Occurrence Handle1:CAS:528:DC%2BD38Xht1Ogug%3D%3D

    PubMed  CAS  Google Scholar 

  38. K Kiyosawa E Tanaka (2002) ArticleTitleCharacteristics of hepatocellular carcinoma in Japan Oncology 62 IssueIDSuppl 1 5–7 Occurrence Handle11868786 Occurrence Handle10.1159/000048269

    Article  PubMed  Google Scholar 

  39. HB El-Serag (2002) ArticleTitleHepatocellular carcinoma and hepatitis C in the united status Hepatology 36 IssueIDSuppl 1 74–83 Occurrence Handle10.1002/hep.1840360710

    Article  Google Scholar 

  40. N Tanaka H Akira T Yamaura M Komatsu E Tanaka K Kiyosawa (2007) ArticleTitleEfficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study J Gastroenterol 42 49–55 Occurrence Handle17322993 Occurrence Handle10.1007/s00535-006-1967-y Occurrence Handle1:CAS:528:DC%2BD2sXitVOltL4%3D

    Article  PubMed  CAS  Google Scholar 

  41. K Iwata M Iwasa N Hara A Matsumoto Y Kobayashi S Watanabe et al. (2006) ArticleTitleIron content and consumption of health foods by patients with chronic hepatitis C J Gastroenterol 41 919–20 Occurrence Handle17048058 Occurrence Handle10.1007/s00535-006-1860-8

    Article  PubMed  Google Scholar 

  42. DM Frazer GJ Anderson (2003) ArticleTitleThe orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol Dis 30 288–97 Occurrence Handle12737947 Occurrence Handle10.1016/S1079-9796(03)00039-1 Occurrence Handle1:CAS:528:DC%2BD3sXjsVGmtrs%3D

    Article  PubMed  CAS  Google Scholar 

  43. E Nemeth MS Tuttle J Powelson MB Vaughn A Donovan DM Ward et al. (2004) ArticleTitleHepcidin regulates iron efflux by binding to ferroportin and inducing its internalization Science 306 2090–3 Occurrence Handle15514116 Occurrence Handle10.1126/science.1104742 Occurrence Handle1:CAS:528:DC%2BD2cXhtVOjsL3K

    Article  PubMed  CAS  Google Scholar 

  44. N Fujita R Sugimoto M Takeo N Urawa R Mifuji H Tanaka et al. (2007) ArticleTitleHepcidin expression in the liver: relatively low level in patients with chronic hepatitis C Mol Med 13 97–104 Occurrence Handle17515961 Occurrence Handle1:CAS:528:DC%2BD2sXmt12rsb4%3D

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fujita, N., Takei, Y. Iron, hepatitis C virus, and hepatocellular carcinoma: iron reduction preaches the gospel for chronic hepatitis C. J Gastroenterol 42, 923–926 (2007). https://doi.org/10.1007/s00535-007-2110-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00535-007-2110-4

Keywords

Navigation